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ChEMBL ligand: CHEMBL360055 (Gallamine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
ChEMBL | Inhibition of Torpedo californica AChE | B | 4.82 | pKi | 15000 | nM | Ki | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
ChEMBL | Inhibition of human AChE | B | 4.43 | pKi | 37000 | nM | Ki | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
ChEMBL | Competitive inhibition of EGFP-fused human M1 receptor N-terminal truncated at 17 residues expressed in HEK293 cells after 4 hrs by FRET assay in presence of para-LRB-AC42 | B | 5.07 | pKi | 8511.38 | nM | Ki | J Med Chem (2012) 55: 2125-2143 [PMID:22329602] |
Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199] | ||||||||
ChEMBL | Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor | B | 6.88 | pEC50 | 131.83 | nM | EC50 | J Med Chem (2007) 50: 5685-5695 [PMID:17944454] |
ChEMBL | Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor | B | 6.89 | pEC50 | 130 | nM | EC50 | J Med Chem (2007) 50: 5685-5695 [PMID:17944454] |
M2 receptor in Human [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
GtoPdb | - | - | 6.3 | pKd | - | - | - |
Mol Pharmacol (1995) 48: 362-78 [PMID:7651370]; Br J Pharmacol (1976) 58: 323-31 [PMID:990587] |
GtoPdb | - | - | 7.6 | pKi | - | - | - |
J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790]; Mol Pharmacol (2003) 64: 180-90 [PMID:12815174]; Mol Pharmacol (2018) 94: 1298-1309 [PMID:30213802] |
M2 receptor in Rat [GtoPdb: 14] [UniProtKB: P10980] | ||||||||
GtoPdb | - | - | 5.6 | pKi | - | - | - | J Pharmacol Exp Ther (1998) 284: 500-7 [PMID:9454790] |
nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708] | ||||||||
GtoPdb | - | - | 6 | pIC50 | ~1000 | nM | IC50 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]