AS99 [Ligand Id: 383] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL33491 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| GtoPdb | - | - | 6.1 | pKi | - | - | - | Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300] |
| ChEMBL | Displacement of specific [3H]DPCPX binding at human adenosine A1 receptor expressed in CHO cells | B | 6.15 | pKi | 700 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
| ChEMBL | Binding affinity of compound for displacement of specific [3H]ZM-241385 binding at human adenosine A2A receptor expressed in CHO cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cells | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| ChEMBL | Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptors | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| GtoPdb | - | - | 8.4 | pKi | - | - | - | Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300] |
| ChEMBL | Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptor | F | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Binding affinity of compound for displacement of specific [3H]MRE3008-F20 binding at human A3 receptors expressed in CHO cells | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2004) 47: 1434-1447 [PMID:14998332] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
