8-cyclopentyltheophylline [Ligand Id: 385] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL106265 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| A1 receptor in Human [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
| GtoPdb | - | - | 8 | pKi | - | - | - | Biochem Pharmacol (1998) 56: 1437-45 [PMID:9827575] |
| Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190] | ||||||||
| ChEMBL | Binding affinity towards adenosine A1 receptor of bovine brain membrane using [3H]-CHA at 20 uM | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2000) 43: 1158-1164 [PMID:10737748] |
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Inhibition of 1 nM [3H]- N6-(phenylisopropyl) adenosine binding to Adenosine A1 receptor in rat cerebral cortical membranes | B | 7.62 | pKi | 24 | nM | Ki | J Med Chem (1989) 32: 1231-1237 [PMID:2724296] |
| ChEMBL | Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand | B | 7.96 | pKi | 11 | nM | Ki | J Med Chem (1992) 35: 407-422 [PMID:1738138] |
| ChEMBL | Inhibition of binding of 1 nM [3H]N-6-(phenylisopropyl)adenosine to adenosine A1 receptor in rat cortical membranes | B | 7.96 | pKi | 10.9 | nM | Ki | J Med Chem (1989) 32: 1873-1879 [PMID:2754711] |
| ChEMBL | Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor | B | 9.34 | pKi | 0.46 | nM | Ki | J Med Chem (1990) 33: 3127-3130 [PMID:2258897] |
| Adenosine A1 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2304404] [UniProtKB: P47745] | ||||||||
| ChEMBL | Binding affinity against adenosine A1 receptor in guinea pig forebrain membranes using N6-[3H]cyclohexyladenosine as radioligand | B | 7.02 | pKi | 95 | nM | Ki | J Med Chem (1992) 35: 3066-3075 [PMID:1501234] |
| A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] | ||||||||
| ChEMBL | Binding affinity towards human adenosine A3 receptor expressed in HEK293 cells using [125I]AB-MECA at 1 uM | B | 5.89 | pKi | 1300 | nM | Ki | J Med Chem (2000) 43: 1158-1164 [PMID:10737748] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
