ATPO [Ligand Id: 4141] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL265301
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL In vitro inhibition of [3H]CPP binding to NMDA receptor. B 4 pIC50 >100000 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]
GluA1/GluA2/GluA3/GluA4/Glutamate receptor ionotropic, AMPA in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093871] [GtoPdb: 444, 445, 446, 447] [UniProtKB: P19490, P19491, P19492, P19493]
ChEMBL In vitro inhibition of [3H]AMPA binding to Ionotropic glutamate receptor AMPA. B 4.46 pIC50 35000 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]
ChEMBL Inhibition of AMPA induced electrophysiological responses in rat cortical slices. F 4.55 pIC50 28000 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]
ChEMBL In vitro inhibition of [3H]CNQX binding to Ionotropic glutamate receptor AMPA. B 5.24 pIC50 5700 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]
GluK1/GluK2/GluK3/GluK4/GluK5/Glutamate receptor ionotropic, kainate in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094119] [GtoPdb: 450, 451, 452, 453, 454] [UniProtKB: P22756, P42260, P42264, Q01812, Q63273]
ChEMBL In vitro inhibition of [3H]KAIN binding to Ionotropic glutamate receptor kainate. B 4 pIC50 >100000 nM IC50 J Med Chem (1996) 39: 1682-1691 [PMID:8648608]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]