nordihydroguiaretic acid [Ligand Id: 4265] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL52 (Actinex, CHX-100, MESO-NDGA, Nordihydroguaiaretic acid) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 5-lipoxygenase in Solanum tuberosum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3317] [UniProtKB: O49150] | ||||||||
| ChEMBL | Inhibitory activity against potato 5LOX | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2006) 49: 1668-1683 [PMID:16509583] |
| Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840] | ||||||||
| ChEMBL | Inhibition of alpha-synuclein fibril formation (unknown origin) incubated for 24 hrs to 7 days by thioflavin S based fluorescence assay | B | 6.66 | pIC50 | 220 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| ChEMBL | Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay | B | 6.68 | pIC50 | 210 | nM | IC50 | Eur J Med Chem (2019) 167: 10-36 [PMID:30743095] |
| Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] | ||||||||
| ChEMBL | Displacement of 5-iodoacetamidofluorescein labeled SRC23 peptide CKENALLRYLLDKDD human androgen receptor AF2 site expressed in Escherichia coli BL21 cells by fluorescence polarization assay | B | 4.3 | pIC50 | >50000 | nM | IC50 | J Med Chem (2011) 54: 8563-8573 [PMID:22047606] |
| ChEMBL | Transcriptional activity at human androgen receptor BF3 site stably transfected in eGFP-expressing human LNCAP cells after 5 days by fluorometric analysis | B | 4.41 | pIC50 | 38800 | nM | IC50 | J Med Chem (2011) 54: 8563-8573 [PMID:22047606] |
| ChEMBL | Displacement of [3H]DHT from human androgen receptor expressed in Escherichia coli BL21 cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2011) 54: 8563-8573 [PMID:22047606] |
| 12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054] | ||||||||
| ChEMBL | Inhibition of human platelet N-terminal His6-tagged 12-lipoxygenase by UV-vis spectrometry | B | 5.23 | pIC50 | 5900 | nM | IC50 | J Nat Prod (2009) 72: 1857-1863 [PMID:19848434] |
| ChEMBL | Inhibitory activity against human platelet 12-lipoxygenase (12-HLO) | B | 5.29 | pIC50 | 5100 | nM | IC50 | J Med Chem (2002) 45: 2659-2661 [PMID:12036375] |
| ChEMBL | Inhibitory activity against human platelet 12-lipoxygenase | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 93-96 |
| ChEMBL | Inhibition of 12-hLO | B | 5.59 | pIC50 | 2600 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
| ChEMBL | Inhibition of His-tagged human platelet 12-lipoxygenase | B | 6.74 | pIC50 | 180 | nM | IC50 | J Nat Prod (2003) 66: 230-235 [PMID:12608855] |
| ChEMBL | Inhibition of human platelet-type 12-lipoxygenase | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2011) 54: 5485-5497 [PMID:21739938] |
| 15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] | ||||||||
| ChEMBL | Inhibition of human 15-lipoxygenase | B | 5.29 | pIC50 | 5100 | nM | IC50 | J Med Chem (2011) 54: 5485-5497 [PMID:21739938] |
| ChEMBL | Inhibitory activity against rabbit reticulocyte 15-lipoxygenase was evaluated by measuring inhibition of the conversion of linoleic acid to hydroperoxide | B | 5.31 | pIC50 | 4900 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 93-96 |
| ChEMBL | Inhibition of 15 LOX | B | 5.42 | pIC50 | 3800 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4026-4029 [PMID:17502145] |
| ChEMBL | Inhibition of human reticulocyte N-terminal His6-tagged 15-lipoxygenase by UV-vis spectrometry | B | 5.96 | pIC50 | 1100 | nM | IC50 | J Nat Prod (2009) 72: 1857-1863 [PMID:19848434] |
| ChEMBL | Inhibition of 15-hLO1 | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
| ChEMBL | Inhibition of human reticulocyte 12/15-lipoxygenase using arachidonic acid/linoleic acid as substrate by fluorescence assay | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2014) 57: 4035-4048 [PMID:24684213] |
| ChEMBL | Inhibitory activity against human reticulocyte 15-lipoxygenase (15-HLO) | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2002) 45: 2659-2661 [PMID:12036375] |
| ChEMBL | Inhibition of His-tagged human reticulocyte 15-lipoxygenase | B | 6.96 | pIC50 | 110 | nM | IC50 | J Nat Prod (2003) 66: 230-235 [PMID:12608855] |
| Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | Inhibitory concentration against isolated rabbit reticulocyte 15-lipoxygenase measured in the presence of linoleic acid | B | 6.96 | pIC50 | 110 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1435-1440 [PMID:15713402] |
| 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] | ||||||||
| ChEMBL | Inhibition of human recombinant N-terminal His-tagged 15-LOX2 expressed in Escherichia coli using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition measured after 20 mins in dark by ferric ion oxidation-xylenol orange assay | B | 4.87 | pIC50 | 13600 | nM | IC50 | J Nat Prod (2019) 82: 3311-3320 [PMID:31774676] |
| ChEMBL | Inhibition of 15-hLO2 | B | 4.96 | pIC50 | 11000 | nM | IC50 | Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117] |
| 5-LOX/Arachidonate 5-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL215] [GtoPdb: 1385] [UniProtKB: P09917] | ||||||||
| ChEMBL | Inhibition of lipoxygenase-5 in human ED273b-BT cells assessed as amount of cysteinyl leukotriene secreted after 24 hrs by immunoassay | B | 4.46 | pIC50 | 35000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4195-4198 [PMID:18541424] |
| ChEMBL | Inhibition of 5-lipoxygenase | B | 5.82 | pIC50 | 1500 | nM | IC50 | Bioorg Med Chem (2010) 18: 5807-5815 [PMID:20667741] |
| ChEMBL | Inhibition of 5-lipoxygenase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Nat Prod (1998) 61: 347-350 [PMID:9544564] |
| ChEMBL | Inhibition of 5LOX | B | 6.42 | pIC50 | 380 | nM | IC50 | Bioorg Med Chem (2008) 16: 10332-10337 [PMID:18976930] |
| ChEMBL | Inhibition against 5-lipoxygenase from guinea pig polymorphonuclear lymphocytes | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (1990) 33: 1186-1194 [PMID:2157009] |
| ChEMBL | Inhibition of 5LOX in human PBMC by EIA assay | B | 6.89 | pIC50 | 130 | nM | IC50 | J Nat Prod (2007) 70: 859-862 [PMID:17378609] |
| ChEMBL | Inhibition of human 5-LOX in human peripheral blood mononuclear leukocytes assessed as inhibition of calymycin A23187-stimulated LTB4 production preincubated for 15 mins before stimulation measured after 15 mins by enzyme immunoassay | B | 6.92 | pIC50 | 120 | nM | IC50 | Bioorg Med Chem (2011) 19: 6340-6347 [PMID:21958738] |
| ChEMBL | Inhibition of human N-terminal His6-tagged 5-lipoxygenase arachidonic acid by UV-vis spectrometry | B | 6.96 | pIC50 | 110 | nM | IC50 | J Nat Prod (2009) 72: 1857-1863 [PMID:19848434] |
| ChEMBL | Inhibition of human 5-lipoxygenase using arachidonic acid as substrate pretreated for 10 mins followed by substrate and ATP addition and measured after 20 mins by H2DCFDA probe based fluorescence assay | B | 7 | pIC50 | 100 | nM | IC50 | Eur J Med Chem (2018) 156: 534-553 [PMID:30025348] |
| ChEMBL | Inhibition of human 5-Lipoxygenase using H2DCFDA as substrate preincubated for 5 mins and measured by Spectrophotometric assay | B | 7.01 | pIC50 | 97 | nM | IC50 | Eur J Med Chem (2020) 190: 112090-112090 [PMID:32018096] |
| ChEMBL | Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compound | F | 7.07 | pIC50 | 85 | nM | IC50 | J Med Chem (1989) 32: 1190-1197 [PMID:2542553] |
| ChEMBL | Inhibition of recombinant human 5-LOX in human PBML assessed as inhibition of A23187-induced LTB4 production preincubated for 15 mins measured after 15 mins by enzyme immunoassay | B | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem (2011) 19: 6316-6328 [PMID:21958737] |
| Arachidonate 5-lipoxygenase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2980] [UniProtKB: Q9BEG3] | ||||||||
| ChEMBL | Tested for the inhibition of lipid peroxidation in bovine brain phospholipid liposomes | F | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (1993) 36: 4099-4107 [PMID:8258834] |
| ChEMBL | Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL). | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1993) 36: 4099-4107 [PMID:8258834] |
| 5-LOX/Arachidonate 5-lipoxygenase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5211] [GtoPdb: 1385] [UniProtKB: P48999] | ||||||||
| ChEMBL | Inhibition of 5-LOX in calcium ionophore A23187-stimulated NMRI mouse macrophage assessed as inhibition of LTC4 production preincubated for 60 mins before stimulation measured after 2 hrs by ELISA | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem (2011) 19: 6340-6347 [PMID:21958738] |
| 5-LOX/Arachidonate 5-lipoxygenase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL312] [GtoPdb: 1385] [UniProtKB: P12527] | ||||||||
| ChEMBL | The compound was tested for inhibitory activity against 5-Lipoxygenase in rat blood | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (1992) 35: 2501-2524 [PMID:1635053] |
| ChEMBL | In vitro inhibition of LTB4 production was measured in rat blood | F | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (1991) 34: 1028-1036 [PMID:1848292] |
| ChEMBL | Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation) | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (1990) 33: 2744-2749 [PMID:2213827] |
| ChEMBL | In vitro inhibitory concentration against 5-lipoxygenase in RBL-1 cells | B | 6.39 | pIC50 | 410 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 845-848 [PMID:11277534] |
| ChEMBL | In vitro inhibition of 5-lipoxygenase (5-lo) from the 20000 g supernatant of RBI-1 cells | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1991) 34: 2158-2165 [PMID:2066989] |
| ChEMBL | Inhibitory activity against rat basophilic leukemia cell 5-lipoxygenase | B | 6.4 | pIC50 | 400 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 93-96 |
| ChEMBL | In vitro inhibitory activity against RBL-1 5-LO | B | 6.4 | pIC50 | 400 | nM | IC50 | J Med Chem (1987) 30: 574-580 [PMID:3820229] |
| ChEMBL | In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay) | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1990) 33: 2744-2749 [PMID:2213827] |
| ChEMBL | Ability to inhibit 5-lipoxygenase by using a crude preparation of the cytosolic enzyme from the rat basophilic leukemia (RBL-1) cell line | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (1990) 33: 360-370 [PMID:2104936] |
| ChEMBL | In vitro inhibition of RBL-1 5-lipoxygenase | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1987) 30: 2216-2221 [PMID:3681891] |
| ChEMBL | Inhibition of 5-lipoxygenase by measuring 5-HETE levels in RBL-1 cell-free supernatant | F | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (1996) 39: 246-252 [PMID:8568814] |
| ChEMBL | In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1993) 36: 3904-3909 [PMID:8254620] |
| ChEMBL | Inhibition of 5-lipoxygenase from rat basophilic leukemia(RBL-1) cells | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 339-344 |
| Cyclooxygenase-1 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2860] [UniProtKB: O62664] | ||||||||
| ChEMBL | Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLC | B | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem (2009) 17: 558-568 [PMID:19097798] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of COX2 in LPS-stimulated human blood | B | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem (2009) 17: 558-568 [PMID:19097798] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of human placental microsome CYP19 | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 3050-3064 [PMID:20413308] |
| Estradiol 17-beta-dehydrogenase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3181] [UniProtKB: P14061] | ||||||||
| ChEMBL | Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting method | B | 5.26 | pIC50 | 5500 | nM | IC50 | J Nat Prod (2017) 80: 965-974 [PMID:28319389] |
| hydroxysteroid 17-beta dehydrogenase 2/Estradiol 17-beta-dehydrogenase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2789] [GtoPdb: 3094] [UniProtKB: P37059] | ||||||||
| ChEMBL | Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation counting method | B | 6.42 | pIC50 | 380 | nM | IC50 | J Nat Prod (2017) 80: 965-974 [PMID:28319389] |
| Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Inhibition of IGF1R | B | 6.05 | pIC50 | 900 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 4026-4029 [PMID:17502145] |
| BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
| ChEMBL | The compound was tested for its inhibitory activity against LTB4 in human PMN | B | 7.07 | pIC50 | 85 | nM | IC50 | J Med Chem (1992) 35: 1299-1318 [PMID:1313879] |
| Lipoxygenase in Glycine max (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641359] [UniProtKB: Q39829] | ||||||||
| ChEMBL | Inhibition of soybean LOX assessed as reduction in conversion of sodium linoleate to 13-hydroperoxylinoleic acid by UV spectroscopy | B | 4.29 | pIC50 | 51000 | nM | IC50 | Bioorg Med Chem (2014) 22: 6586-6594 [PMID:25456384] |
| ChEMBL | Inhibition of soybean LOX using sodium linoleate as substrate by spectrophotometry | B | 4.55 | pIC50 | 28000 | nM | IC50 | Eur J Med Chem (2014) 86: 502-514 [PMID:25203780] |
| ChEMBL | Inhibition of soybean lipoxygenase | B | 4.55 | pIC50 | 28000 | nM | IC50 | Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112] |
| ChEMBL | Inhibition of soybean lipoxygenase after 5 mins by colorimetric assay | B | 5.03 | pIC50 | 9230 | nM | IC50 | Bioorg Med Chem (2014) 22: 4151-4161 [PMID:24938495] |
| ChEMBL | Inhibition of soybean lipoxygenase using sodium linoleate as substrate by UV-based analysis | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2019) 62: 2184-2201 [PMID:30715875] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.9 | pIC50 | 12589.25 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.1 | pIC50 | 7943.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| Plasmodium yoelii yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612328] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs | F | 4.52 | pIC50 | 30000 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 1215-1220 [PMID:18212104] |
| Replicase polyprotein 1ab in Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295557] [UniProtKB: K9N7C7] | ||||||||
| ChEMBL | MERS_3CL Pro protease inhibition IC50 by FRET kind of response from peptide substrate | F | 5 | pIC50 | >10000 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
| CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] | ||||||||
| ChEMBL | SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate | F | 5.59 | pIC50 | 2590 | nM | IC50 | Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen |
| Seed lipoxygenase-1 in Glycine max (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4586] [UniProtKB: P08170] | ||||||||
| ChEMBL | Inhibition of soybean LOX type 1 pre-incubated for 4 mins at 7x10'-7 w/v concentration assessed as inhibition of sodium linoleate to 13-hydroperoxylinoleic acid | B | 4.5 | pIC50 | 31300 | nM | IC50 | Eur J Med Chem (2012) 47: 111-124 [PMID:22119153] |
| ChEMBL | In vitro inhibitory activity against 5-lipoxygenase obtained from potato | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4842-4845 [PMID:16143531] |
| ChEMBL | In vitro inhibitory activity against 15-lipoxygenase obtained from soybean | B | 5.46 | pIC50 | 3500 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 4842-4845 [PMID:16143531] |
| ChEMBL | Inhibitory activity against soybean 15LOX | B | 5.46 | pIC50 | 3500 | nM | IC50 | J Med Chem (2006) 49: 1668-1683 [PMID:16509583] |
| ChEMBL | Inhibition of soybean lipoxygenase after 7 mins | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem (2007) 15: 951-961 [PMID:17126019] |
| ChEMBL | Inhibitory activity against soybean 1-lipoxygenase (SLO) | B | 6.74 | pIC50 | 180 | nM | IC50 | J Med Chem (2002) 45: 2659-2661 [PMID:12036375] |
| Transcription factor AP1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111421] [UniProtKB: P01100, P05412] | ||||||||
| ChEMBL | Inhibition of Fos-Jun dimer formation (unknown origin) | B | 8.1 | pIC50 | 7.9 | nM | IC50 | J Med Chem (2014) 57: 6930-6948 [PMID:24831826] |
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.45 | pEC50 | 35481.34 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.46 | pEC50 | 35000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Calcium-5 dye based fluorescence assay | B | 5.31 | pEC50 | 4900 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
| transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
| ChEMBL | Inhibition of TTR L55P mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assay | B | 4.9 | pEC50 | 12600 | nM | EC50 | J Med Chem (2014) 57: 8928-8935 [PMID:25314129] |
| ChEMBL | Inhibition of TTR I84T mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assay | B | 5.07 | pEC50 | 8500 | nM | EC50 | J Med Chem (2014) 57: 8928-8935 [PMID:25314129] |
| ChEMBL | Inhibition of TTR V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of amyloid fibril formation by fluorescence assay | B | 5.14 | pEC50 | 7300 | nM | EC50 | J Med Chem (2014) 57: 8928-8935 [PMID:25314129] |
| Uncharacterized protein in Solanum lycopersicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105968] [UniProtKB: K4CF70] | ||||||||
| ChEMBL | Inhibition of recombinant Solanum lycopersicum (tomato) fatty acid 13-hydroperoxide lyase using (13S)-HPOT substrate by spectrophotometry | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Pestic Sci (2011) 36: 58-62 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
