teriparatide [Ligand Id: 4448] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL525610 ((1-34)-human parathyroid hormone, 1-34-human pth, Bonsity, Forsteo, Forteo, Human parathyroid hormone 1-34, LY 333334, LY-333334, LY333334, Pth (1-34), Teriparatide, Teriparatide rdna, Teriparatide recombinant human, ZT-034) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| PTH1 receptor/Parathyroid hormone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1793] [GtoPdb: 331] [UniProtKB: Q03431] | ||||||||
| GtoPdb | - | - | 7.4 | pIC50 | - | - | - | J Biol Chem (1996) 271: 19888-93 [PMID:8702701] |
| ChEMBL | Displacement of 125I-PTH (1 to 15 residues) from human PTHR1 expressed in African green monkey COS7 cell membranes at 300 uM after 90 mins by gamma counting analysis | B | 10.1 | pIC50 | 0.08 | nM | IC50 | J Med Chem (2018) 61: 5949-5962 [PMID:29932656] |
| ChEMBL | Agonist activity at human PTHR1 expressed in HKRKB7 cells assessed as accumulation of intracellular cAMP after 20 mins by enzyme immunoassay | F | 8.6 | pEC50 | 2.5 | nM | EC50 | J Med Chem (2018) 61: 5949-5962 [PMID:29932656] |
| ChEMBL | Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP mobilization | F | 9 | pEC50 | 1 | nM | EC50 | J Med Chem (2010) 53: 4332-4353 [PMID:20218623] |
| ChEMBL | Agonist activity at PTH1R overexpressed in HEK293 cells assessed as intracellular cAMP production | F | 9.52 | pEC50 | 0.3 | nM | EC50 | J Med Chem (2010) 53: 4332-4353 [PMID:20218623] |
| PTH1 receptor in Rat [GtoPdb: 331] [UniProtKB: P25961] | ||||||||
| GtoPdb | - | - | 8.7 | pIC50 | - | - | - | J Biol Chem (1995) 270: 6584-8 [PMID:7896796] |
| PTH2 receptor in Human [GtoPdb: 332] [UniProtKB: P49190] | ||||||||
| GtoPdb | - | - | 7.8 | pIC50 | - | - | - |
J Biol Chem (1996) 271: 19888-93 [PMID:8702701]; J Pharmacol Exp Ther (2001) 299: 678-90 [PMID:11602681] |
| PTH2 receptor in Rat [GtoPdb: 332] [UniProtKB: P70555] | ||||||||
| GtoPdb | - | - | 6.3 | pIC50 | - | - | - | J Pharmacol Exp Ther (2001) 299: 678-90 [PMID:11602681] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
