DEPX [Ligand Id: 445] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL11348 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190] | ||||||||
| ChEMBL | Binding affinity against bovine brain adenosine A1 receptor by using N6-[3H]- cyclohexyladenosine | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (1985) 28: 1071-1079 [PMID:2991519] |
| A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
| ChEMBL | Inhibition of [3H]- PIA binding at adenosine A1 receptor on rat cerebral cortex membranes. | B | 7.19 | pKi | 65 | nM | Ki | J Med Chem (1987) 30: 211-214 [PMID:3806597] |
| ChEMBL | Inhibition of binding of 1 nM [3H]N-6-(phenylisopropyl)adenosine to adenosine A1 receptor in rat cortical membranes | B | 7.35 | pKi | 44.5 | nM | Ki | J Med Chem (1989) 32: 1873-1879 [PMID:2754711] |
| ChEMBL | Binding affinity against Adenosine A1 receptor in rat brain membrane, using [3H]N6-cyclohexyladenosine as the radioligand | B | 7.36 | pKi | 44 | nM | Ki | J Med Chem (1989) 32: 2247-2254 [PMID:2795597] |
| ChEMBL | Binding affinity to adenosine A1 receptor of rat brain membranes without NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding | B | 7.32 | pIC50 | 48 | nM | IC50 | J Med Chem (1988) 31: 745-751 [PMID:3351850] |
| ChEMBL | Binding affinity towards adenosine A1 receptor of rat brain membranes with 1 M NaCl by inhibition of [125-I]-labeled aminobenzyl adenosine binding | B | 7.49 | pIC50 | 32 | nM | IC50 | J Med Chem (1988) 31: 745-751 [PMID:3351850] |
| A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] | ||||||||
| ChEMBL | Binding affinity at human Adenosine A2B receptor expressed in HEK293 cells, using [125I]ABOPX as radioligand | B | 7.21 | pKi | 62 | nM | Ki | J Med Chem (2002) 45: 2131-2138 [PMID:12014951] |
| GtoPdb | - | - | 7.9 | pKi | - | - | - | Mol Pharmacol (1999) 56: 705-13 [PMID:10496952] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
