fenoprofen [Ligand Id: 4820] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1297 (53858, Fenoprofen, LILLY-53858, Nalfon, NSC-757813, Progesic) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 6.84 | pIC50 | 145 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| GtoPdb | - | - | 6.84 | pIC50 | 145 | nM | IC50 | National Toxicology Program: Dept of Health and Human Services.. DrugMatrix |
| Cyclooxygenase-2 in Sheep (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4102] [UniProtKB: P79208] | ||||||||
| ChEMBL | Inhibition of ovine COX2 assessed as reduction in PGH2 production by enzyme immunoassay | B | 4.58 | pIC50 | 26300 | nM | IC50 | Bioorg Med Chem (2018) 26: 4113-4126 [PMID:29980364] |
| SMCT1 in Human [GtoPdb: 922] [UniProtKB: Q8N695] | ||||||||
| GtoPdb | - | - | 4.57 | pIC50 | 27000 | nM | IC50 | Pharm Res (2006) 23: 1209-16 [PMID:16729224] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
