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ChEMBL ligand: CHEMBL40833 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
ChEMBL | Inhibition of human nNOS | B | 6.8 | pIC50 | 160 | nM | IC50 | Nat Chem Biol (2008) 4: 700-707 [PMID:18849972] |
ChEMBL | In vitro inhibition of human neuronal nitric oxide synthase. | B | 6.96 | pIC50 | 110 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
ChEMBL | Inhibitory activity against neuronal nitric oxide synthase | B | 7.12 | pIC50 | 75 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430] |
ChEMBL | In vitro inhibition of human neuronal nitric oxide synthase | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2004) 47: 1575-1586 [PMID:14998342] |
Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
ChEMBL | In vitro inhibition of rat neuronal nitric oxide synthase | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2004) 47: 1575-1586 [PMID:14998342] |
Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
ChEMBL | Inhibition of human eNOS | B | 6.49 | pIC50 | 320 | nM | IC50 | Nat Chem Biol (2008) 4: 700-707 [PMID:18849972] |
ChEMBL | In vitro inhibition of human endothelial nitric oxide synthase. | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
ChEMBL | In vitro inhibition of human endothelial nitric oxide synthase | B | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (2004) 47: 1575-1586 [PMID:14998342] |
ChEMBL | Inhibitory activity against endothelial nitric oxide synthase (eNOS) | B | 7.14 | pIC50 | 72 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430] |
Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
ChEMBL | Inhibitory activity against inducible nitric oxide synthase (iNOS) | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1975-1978 [PMID:10987430] |
ChEMBL | In vitro inhibition of human Inducible nitric oxide synthase. | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2004) 47: 3320-3323 [PMID:15163211] |
ChEMBL | Inhibition of human iNOS | B | 6.92 | pIC50 | 120 | nM | IC50 | Nat Chem Biol (2008) 4: 700-707 [PMID:18849972] |
GtoPdb | - | - | 7.4 | pIC50 | 39.8 | nM | IC50 | Br J Pharmacol (1996) 119: 1101-8 [PMID:8937711] |
ChEMBL | In vitro inhibition of human inducible nitric oxide synthase | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (2004) 47: 1575-1586 [PMID:14998342] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]