BAY607550 [Ligand Id: 5147] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL370962 (BAY-60-7550) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| phosphodiesterase 2A/Phosphodiesterase 2A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2652] [GtoPdb: 1297] [UniProtKB: O00408] | ||||||||
| ChEMBL | Inhibition of PDE2 (unknown origin) using [3H]cAMP or [3H]cGMP as substrate measured after 30 mins by liquid scintillation counting method | B | 8.32 | pIC50 | 4.8 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 481-486 [PMID:30554955] |
| ChEMBL | Inhibition of cGMP stimulated human PDE2A | B | 8.33 | pIC50 | 4.7 | nM | IC50 | Medchemcomm (2015) 6: 2063-2080 |
| ChEMBL | Inhibition of human phosphodiesterase 2 | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2005) 48: 3449-3462 [PMID:15887951] |
| ChEMBL | Inhibition of PDE2A (unknown origin) | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2017) 60: 5673-5698 [PMID:28574706] |
| ChEMBL | Inhibition of PDE2A (unknown origin) using [3H]cGMP as substrate after 30 mins by scintillation proximity assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2017) 60: 7677-7702 [PMID:28796496] |
| ChEMBL | Inhibition of PDE2 (unknown origin) using [3H]cAMP as substrate measured after 30 mins by scintillation proximity assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 481-486 [PMID:30554955] |
| ChEMBL | Inhibition of human His-tagged PDE2A catalytic domain (578 to 919 residues) expressed in Escherichia coli BL21-CodonPlus(DE3) cells using cGMP as substrate by HTRF assay | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2016) 59: 7029-7065 [PMID:26908025] |
| ChEMBL | Inhibition of PDE2a (unknown origin) using cAMP as substrate after 30 mins by Scintillation proximity assay | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2017) 60: 2037-2051 [PMID:28165743] |
| GtoPdb | - | - | 8.8 | pIC50 | 1.58 | nM | IC50 | Neuropharmacology (2004) 47: 1081-92 [PMID:15555642] |
| ChEMBL | Inhibition of PDE2A (unknown origin) | B | 9.07 | pIC50 | 0.86 | nM | IC50 | J Med Chem (2017) 60: 7658-7676 [PMID:28759228] |
| ChEMBL | Inhibition of full length recombinant human FLAG-tagged PDE2A3 expressed in sf21 cells using [3H]cGMP as substrate by scintillation proximity assay | B | 9.3 | pIC50 | 0.5 | nM | IC50 | J Med Chem (2017) 60: 5673-5698 [PMID:28574706] |
| ChEMBL | Inhibition of human PDE2A1 using 3',5'-[3H]cGMP as substrate after 30 mins by scintillation proximity assay | B | 10.52 | pIC50 | 0.03 | nM | IC50 | J Med Chem (2018) 61: 3626-3640 [PMID:29601185] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
