bromoenol lactone [Ligand Id: 5149] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL6206 (Bromoenol Lactone, BTNP) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
| ChEMBL | Irreversible inhibition of fatty acid amide hydrolase | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
| Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
| ChEMBL | Inhibition of FAAH in rat brain assessed as hydrolysis of anandamide | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2008) 51: 7327-7343 [PMID:18983142] |
| iPLA2-G6/Calcium-independent phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3213] [GtoPdb: 1431] [UniProtKB: O60733] | ||||||||
| ChEMBL | Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2. | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1993) 36: 95-100 [PMID:8421294] |
| ChEMBL | Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2. | B | 7 | pIC50 | >100 | nM | IC50 | J Med Chem (1993) 36: 95-100 [PMID:8421294] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.8 | pIC50 | 15848.93 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| TRPC5 in Mouse [GtoPdb: 490] [UniProtKB: Q9QX29] | ||||||||
| GtoPdb | - | - | 4.97 | pIC50 | - | - | - | J Pharmacol Exp Ther (2011) 339: 329-40 [PMID:21795434] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
