CGP53353 [Ligand Id: 5163] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL7939 (CGP-53353) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cells | F | 5.66 | pIC50 | 2200 | nM | IC50 | J Med Chem (1994) 37: 1015-1027 [PMID:8151612] |
| ChEMBL | Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD) | B | 6.15 | pIC50 | 700 | nM | IC50 | J Med Chem (1994) 37: 1015-1027 [PMID:8151612] |
| platelet derived growth factor receptor beta/platelet derived growth factor receptor alpha/Platelet-derived growth factor receptor in Mouse (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096980] [GtoPdb: 1804, 1803] [UniProtKB: P05622, P26618] | ||||||||
| ChEMBL | Inhibition of PDGF-dependent autophosphorylation of PDGF-R in mouse BALB/c3T3 cells | F | 4 | pIC50 | 100000 | nM | IC50 | J Med Chem (1994) 37: 1015-1027 [PMID:8151612] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] | ||||||||
| ChEMBL | Inhibitory activity against c-src tyrosine kinase | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (1994) 37: 1015-1027 [PMID:8151612] |
| protein kinase C beta in Human [GtoPdb: 1483] [UniProtKB: P05771] | ||||||||
| GtoPdb | - | - | 6.4 | pIC50 | 398 | nM | IC50 | Mol Endocrinol (1996) 10: 1273-81 [PMID:9121494] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
