cytosporone B [Ligand Id: 5424] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1221517 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Nerve Growth factor IB/Nuclear receptor subfamily 4 group A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293229] [GtoPdb: 629] [UniProtKB: P22736] | ||||||||
| ChEMBL | Binding affinity to NuR77-LBD receptor expressed in human BGC823 cells | B | 5.82 | pKd | 1510 | nM | Kd | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Binding affinity to Nur77 receptor expressed in human BGC823 cells | B | 6.13 | pKd | 740 | nM | Kd | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Binding affinity to Nur77 Y453A mutant expressed in human BGC823 cells | B | 6.14 | pKd | 720 | nM | Kd | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-Nur77 assessed as transactivation after 12 hrs by luciferase reporter gene assay | F | 9.56 | pEC50 | 0.28 | nM | EC50 | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
| ChEMBL | Agonist activity at nuclear orphan receptor Nur77 expressed in human BGC823 cells co-transfected with fused GAL4-LBD assessed as transactivation after 12 hrs by luciferase reporter gene assay | F | 9.94 | pEC50 | 0.12 | nM | EC50 | Nat Chem Biol (2008) 4: 548-556 [PMID:18690216] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
