DAPI [Ligand Id: 5498] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL48217 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cell division protein ftsZ in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6] | ||||||||
| ChEMBL | Binding affinity to Escherichia coli FtsZ by fluorescence anisotrophy | B | 4.78 | pKd | 16600 | nM | Kd | Eur J Med Chem (2015) 95: 1-15 [PMID:25791674] |
| Glandular kallikrein in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243909] [UniProtKB: P00752] | ||||||||
| ChEMBL | Competitive reversible inhibition of porcine pancreatic kallikrein using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 180 mins by Michaelis-Menten plot analysis | B | 5.57 | pKi | 2700 | nM | Ki | J Med Chem (1978) 21: 613-623 [PMID:671460] |
| Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
| ChEMBL | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 | F | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (2008) 51: 6927-6944 [PMID:18841956] |
| ChEMBL | Antiparasitic activity against Plasmodium falciparum K1 | F | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem (2011) 19: 2156-2167 [PMID:21421317] |
| ChEMBL | Antiparasitic activity against Plasmodium falciparum K1 | F | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem (2010) 18: 557-566 [PMID:20031421] |
| Thrombin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4471] [UniProtKB: P00735] | ||||||||
| ChEMBL | Competitive reversible inhibition of bovine thrombin using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 40 mins by Michaelis-Menten plot analysis | B | 5.08 | pKi | 8370 | nM | Ki | J Med Chem (1978) 21: 613-623 [PMID:671460] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
