ChEMBL ligand: CHEMBL499876
GPR55/G-protein coupled receptor 55 in Human [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6] There should be some charts here, you may need to enable JavaScript!
GPR18/N-arachidonyl glycine receptor in Human [ChEMBL: CHEMBL2384898] [GtoPdb: 89] [UniProtKB: Q14330] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GPR55/G-protein coupled receptor 55 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075322] [GtoPdb: 109] [UniProtKB: Q9Y2T6]
ChEMBL	Antagonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as inhibition of lysophosphatidylinositol-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	F	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
ChEMBL	Agonist activity at Prolink1-tagged human GPR55 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	B	5	pEC50	>10000	nM	EC50	ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
GtoPdb	-	-	5.71	pEC50	1944	nM	EC50	Br J Pharmacol (2007) 152: 1092-101 [PMID:17876302]
GtoPdb	-	-	8.6	pEC50	2.5	nM	EC50	Br J Pharmacol (2007) 152: 825-31 [PMID:17704827]
ChEMBL	Activation of recombinant human GPR55 expressed in HEK293 cells assessed as increase in [35S]-GTPgammaS stimulation incubated for 60 min by scintillation counting method	F	8.7	pEC50	2	nM	EC50	J Med Chem (2020) 63: 12137-12155 [PMID:32804502]
GPR18/N-arachidonyl glycine receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384898] [GtoPdb: 89] [UniProtKB: Q14330]
ChEMBL	Antagonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as inhibition of THC-induced beta arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	F	5	pIC50	>10000	nM	IC50	ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
ChEMBL	Agonist activity at Prolink1-tagged human GPR18 receptor expressed in CHO cells assessed as induction of beta-arrestin recruitment after 90 mins by beta-galactosidase based topcount luminescence analysis	B	5	pEC50	>10000	nM	EC50	ACS Med Chem Lett (2020) 11: 2024-2031 [PMID:33062188]
GtoPdb	-	-	6.08	pEC50	835.7	nM	EC50	Br J Pharmacol (2012) 165: 2414-24 [PMID:21595653]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]