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ChEMBL ligand: CHEMBL2311146 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] | ||||||||
ChEMBL | In vitro binding affinity for porcine Adenosine A1 receptor | B | 8.86 | pKd | 1.37 | nM | Kd | J Med Chem (2002) 45: 5150-5156 [PMID:12408725] |
ChEMBL | In vitro binding affinity for human Adenosine A1 receptor expressed in CHO-K1 cells | B | 8.9 | pKd | 1.26 | nM | Kd | J Med Chem (2002) 45: 5150-5156 [PMID:12408725] |
GtoPdb | - | - | 8.9 | pKi | 1.26 | nM | Ki | J Med Chem (2002) 45: 5150-6 [PMID:12408725] |
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190] | ||||||||
ChEMBL | In vitro binding affinity for Adenosine A1 receptor of bovine cortex | B | 9.74 | pKi | 0.18 | nM | Ki | J Med Chem (2002) 45: 5150-5156 [PMID:12408725] |
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] | ||||||||
ChEMBL | In vitro binding affinity at rat Adenosine A1 receptor | B | 9.2 | pKd | 0.63 | nM | Kd | J Med Chem (2002) 45: 5150-5156 [PMID:12408725] |
GtoPdb | - | - | 9.2 | pKi | 0.63 | nM | Ki | J Med Chem (2002) 45: 5150-6 [PMID:12408725] |
A2A receptor in Human [GtoPdb: 19] [UniProtKB: P29274] | ||||||||
GtoPdb | - | - | 6.03 | pKi | 940 | nM | Ki | J Med Chem (2002) 45: 5150-6 [PMID:12408725] |
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] | ||||||||
GtoPdb | - | - | 6.09 | pKi | 812 | nM | Ki | J Med Chem (2002) 45: 5150-6 [PMID:12408725] |
ChEMBL | In vitro binding affinity at Adenosine A2A receptor of rat cortex | B | 6.09 | pKi | 812 | nM | Ki | J Med Chem (2002) 45: 5150-5156 [PMID:12408725] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]