casopitant [Ligand Id: 5758] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1672054 (Casopitant, Gw679769, GW-679769, GW679769, Rezonic, Zunrisa) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| GtoPdb | - | - | 9.4 | pKi | - | - | - |
Expert Opin Ther Pat (2010) 20: 1019-45 [PMID:20533894]; J Recept Signal Transduct Res (2013) 33: 333-7 [PMID:24106886] |
| ChEMBL | Displacement of [3H]SP from human NK1 receptor expressed in CHO cells by liquid scintillation counting | B | 9.48 | pKi | 0.33 | nM | Ki | J Med Chem (2011) 54: 1071-1079 [PMID:21229983] |
| ChEMBL | Displacement of [3H]GR205171 from human NK1 receptor in cortex homogenate by liquid scintillation counting | B | 9.9 | pKi | 0.13 | nM | Ki | J Med Chem (2011) 54: 1071-1079 [PMID:21229983] |
| sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
| ChEMBL | Binding affinity to sigma 1 receptor | B | 5.53 | pKi | 2980 | nM | Ki | J Med Chem (2011) 54: 1071-1079 [PMID:21229983] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
