ChEMBL ligand: CHEMBL379630
L-type amino acid transporter 1 in Human [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650] There should be some charts here, you may need to enable JavaScript!
HCA3 receptor in Human [GtoPdb: 313] [UniProtKB: P49019] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
L-type amino acid transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4459] [GtoPdb: 896] [UniProtKB: Q01650]
ChEMBL	Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis relative to BCH	B	4.34	pIC50	46000	nM	IC50	J Med Chem (2018) 61: 7358-7373 [PMID:30048132]
HCA3 receptor in Human [GtoPdb: 313] [UniProtKB: P49019]
GtoPdb	-	-	5.04	pEC50	9020	nM	EC50	Proc Natl Acad Sci USA (2009) 106: 3930-4 [PMID:19237584]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]