ChEMBL ligand: CHEMBL1513 (Aprovel, Avapro, BMS-186295, Ifirmasta, Irbesartan, Irbesartan bms, Irbesartan teva, Irbesartan zentiva, Karvea, NSC-758696, Sabervel, Sarbevel, SR 47436, SR-47436)
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973] There should be some charts here, you may need to enable JavaScript!
ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] There should be some charts here, you may need to enable JavaScript!
BLT2 receptor/Leukotriene B4 receptor 2 in Human [ChEMBL: CHEMBL3191] [GtoPdb: 268] [UniProtKB: Q9NPC1] There should be some charts here, you may need to enable JavaScript!
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] AT1 receptor/Type-1A angiotensin II receptor in Rat [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095] There should be some charts here, you may need to enable JavaScript!
AT1 receptor/Type-1 angiotensin II receptor in Human [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556] There should be some charts here, you may need to enable JavaScript!
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556] AT1 receptor/Type-1B angiotensin II receptor in Rat [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Sodium/bile acid and sulphated solute cotransporter 1/Bile acid transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5287] [GtoPdb: 959] [UniProtKB: Q14973]
GtoPdb	-	-	4.92	pKi	11900	nM	Ki	Mol Pharm (2013) 10: 1008-19 [PMID:23339484]
ChEMBL	Inhibition of NTCP (unknown origin)	B	4.52	pIC50	30000	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126623-126623 [PMID:31439379]
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL	Inhibitory concentration against endothelin receptor type A	B	5	pKi	>10000	nM	Ki	J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL	Binding affinity to ETA receptor	B	5	pKi	10000	nM	Ki	J Med Chem (2012) 55: 9363-9392 [PMID:22931505]
BLT2 receptor/Leukotriene B4 receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3191] [GtoPdb: 268] [UniProtKB: Q9NPC1]
ChEMBL	Agonist activity at human BLT2 overexpressed in CHO-K1 cells assessed as accumulation of inositol monophosphate measured after 90 mins by HTRF assay	F	6.39	pEC50	410	nM	EC50	ACS Med Chem Lett (2021) 12: 1261-1266 [PMID:34413955]
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
GtoPdb	-	-	8.8	pIC50	1.58	nM	IC50	Br J Pharmacol (1999) 126: 1057-65 [PMID:10193788]
AT1 receptor/Type-1A angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL329] [GtoPdb: 34] [UniProtKB: P25095]
ChEMBL	Displacement of [125I]- Ang II from type 1 Angiotensin II receptor	B	9.05	pIC50	0.9	nM	IC50	Bioorg Med Chem Lett (1994) 4: 1527-1530
AT1 receptor/Type-1 angiotensin II receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL227] [GtoPdb: 34] [UniProtKB: P30556]
ChEMBL	In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5	B	8.7	pKi	2	nM	Ki	J Med Chem (2002) 45: 4794-4798 [PMID:12361407]
ChEMBL	Binding affinity against AT1 in human hepatoma cell line, PLC-PRF-5	B	8.7	pKi	2	nM	Ki	J Med Chem (2000) 43: 2685-2697 [PMID:10893306]
ChEMBL	Compound was evaluated for its binding affinity towards human Angiotensin II receptor, type 1	B	8.96	pKi	1.1	nM	Ki	J Med Chem (2002) 45: 3829-3835 [PMID:12190306]
ChEMBL	Inhibitory concentration against angiotensin II receptor, type 1	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL	Binding affinity to AT1 receptor	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2012) 55: 9363-9392 [PMID:22931505]
ChEMBL	Binding affinity to angiotensin AT1 receptor	B	7.68	pIC50	20.8	nM	IC50	Bioorg Med Chem (2010) 18: 8418-8456 [PMID:21071232]
ChEMBL	Antagonist activity at human AT1 overexpressed in CHO-K1 cells in presence of 10 nM [Val5-angiotensin II measured after 90 mins by HTRF based IP-one assay	F	8.22	pIC50	6	nM	IC50	ACS Med Chem Lett (2021) 12: 1261-1266 [PMID:34413955]
GtoPdb	-	-	8.8	pIC50	1.58	nM	IC50	Br J Pharmacol (1999) 126: 1057-65 [PMID:10193788]
AT1 receptor in Human [GtoPdb: 34] [UniProtKB: P30556]
GtoPdb	-	-	8.8	pIC50	1.58	nM	IC50	Br J Pharmacol (1999) 126: 1057-65 [PMID:10193788]
AT1 receptor/Type-1B angiotensin II receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL263] [GtoPdb: 34] [UniProtKB: P29089]
ChEMBL	Compound was evaluated for its binding affinity towards rat Angiotensin II receptor, type 1	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2002) 45: 3829-3835 [PMID:12190306]
ChEMBL	Binding affinity for Angiotensin II receptor, type 1 measured by ability to displace [125I]- A II from its specific binding site in rat liver membrane	B	8.89	pIC50	1.3	nM	IC50	J Med Chem (1993) 36: 3371-3380 [PMID:8230127]
ChEMBL	In vitro inhibition of specific binding of [125I]AII to Angiotensin II receptor, type 1 from rat liver membrane	B	8.89	pIC50	1.3	nM	IC50	Bioorg Med Chem Lett (1994) 4: 157-162

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]