D4476 [Ligand Id: 5940] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL410456 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| casein kinase 1 alpha 1/Casein kinase I alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2793] [GtoPdb: 1995] [UniProtKB: P48729] | ||||||||
| GtoPdb | - | - | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2012) 56: 30-8 [PMID:22944772] |
| ChEMBL | Inhibition of CK1 using KRRRALS(p)VASLPGL as substrate after 40 mins by scintillation counter | B | 6.52 | pIC50 | 300 | nM | IC50 | Eur J Med Chem (2012) 56: 30-38 [PMID:22944772] |
| casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
| GtoPdb | - | - | 6.52 | pIC50 | 300 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| ChEMBL | Inhibition of CK1delta | B | 6.52 | pIC50 | 300 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of CK1delta in the presence of 100uM ATP | B | 6.52 | pIC50 | 300 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| ChEMBL | Inhibition of human CK1D using KRRRAL[pS]VASLPGL as substrate by [gamma-33P]-ATP assay | B | 6.77 | pIC50 | 171 | nM | IC50 | Eur J Med Chem (2019) 161: 456-467 [PMID:30384048] |
| casein kinase 1 delta/Casein kinase I delta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4484] [GtoPdb: 1997] [UniProtKB: Q06486] | ||||||||
| ChEMBL | Inhibition of rat CK1delta in presence of 20 uM ATP | B | 6.45 | pIC50 | 353.3 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5578-5585 [PMID:24007918] |
| ChEMBL | Inhibition of GST-fused rat CK1delta expressed in Escherichia coli using phosphorylated peptide TFRPRTSpSNASTIS as substrate | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (2009) 52: 7618-7630 [PMID:19591487] |
| casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] | ||||||||
| ChEMBL | Inhibition of human CK1E using KRRRAL[pS]VASLPGL as substrate by [gamma-33P]-ATP assay | B | 6.47 | pIC50 | 338 | nM | IC50 | Eur J Med Chem (2019) 161: 456-467 [PMID:30384048] |
| Casein kinase II subunit alpha in Schizosaccharomyces pombe 972h- (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075255] [UniProtKB: P40231] | ||||||||
| ChEMBL | Inhibition of Schizosaccharomyces pombe CK1 | B | 6.7 | pIC50 | 200 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibition of p38alpha | B | 4.92 | pIC50 | 12000 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of GST-fused human p38alpha expressed in Escherichia coli | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2009) 52: 7618-7630 [PMID:19591487] |
| ChEMBL | Inhibition of p38-alpha MAPK in the presence of 50uM ATP | B | 5.24 | pIC50 | 5800 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| ChEMBL | Inhibition of human p38alpha MAPK in presence of 50 uM ATP | B | 5.38 | pIC50 | 4154 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 5578-5585 [PMID:24007918] |
| protein kinase D1/Protein kinase C mu in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3863] [GtoPdb: 1489] [UniProtKB: Q15139] | ||||||||
| ChEMBL | Inhibition of PKD1 in the presence of 50uM ATP | B | 5.04 | pIC50 | 9100 | nM | IC50 | Biochem J (2007) 408: 297-315 [PMID:17850214] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Inhibition of ALK5 | B | 6.3 | pIC50 | 500 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
