Chk2 inhibitor II [Ligand Id: 5954] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL179583 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| checkpoint kinase 2/Serine/threonine-protein kinase Chk2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2527] [GtoPdb: 1988] [UniProtKB: O96017] | ||||||||
| GtoPdb | - | - | 7.43 | pKi | 37 | nM | Ki | Proc Natl Acad Sci USA (2007) 104: 20523-8 [PMID:18077363] |
| ChEMBL | Inhibition of Chk2 | B | 7.43 | pKi | 37 | nM | Ki | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
| ChEMBL | Inhibition of recombinant human Chk2 kinase | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2005) 48: 1873-1885 [PMID:15771432] |
| ChEMBL | Inhibition of chk2 kinase | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 1924-1928 [PMID:16442290] |
| ChEMBL | Inhibition of recombinant human CDS1 using N-terminal biotin-labeled SGLYRSPSMPENLNRPR as substrate in presence of [gamma-33P]-ADP after 3 hrs by scintillation counting method | B | 7.8 | pIC50 | 16 | nM | IC50 | EP-1435947-B1. 2-phenyl benzimidazoles and imidazo-4,5|-pyridines as CDS1/CHK2-inhibitors and adjuvants to chemotherapy or radiation therapy in the treatment of cancer (2007) |
| ChEMBL | Inhibition of recombinant human Chk2 kinase | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (2005) 48: 1873-1885 [PMID:15771432] |
| ChEMBL | Inhibition of human recombinant Chk2 | B | 7.82 | pIC50 | 15 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 6467-6471 [PMID:17937984] |
| ChEMBL | Inhibition of Chk2 | B | 7.82 | pIC50 | 15 | nM | IC50 | Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
