DMBI [Ligand Id: 5958] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL296455
  • Beta-lactamase AmpC in Escherichia coli [ChEMBL: CHEMBL2026] [UniProtKB: P00811]
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  • EPH receptor B2/Ephrin type-B receptor 2 in Human [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
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  • platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
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  • kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Mouse [ChEMBL: CHEMBL3337] [GtoPdb: 1813] [UniProtKB: P35918]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Beta-lactamase AmpC in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2026] [UniProtKB: P00811]
ChEMBL Inhibitory activity against beta-lactamase B 5 pIC50 10000 nM IC50 J Med Chem (2002) 45: 1712-1722 [PMID:11931626]
chymotrypsin C/Chymotrypsin C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2386] [GtoPdb: 2341] [UniProtKB: Q99895]
ChEMBL Inhibitory activity against chymotrypsinogen B 4.52 pIC50 30000 nM IC50 J Med Chem (2002) 45: 1712-1722 [PMID:11931626]
EPH receptor B2/Ephrin type-B receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3290] [GtoPdb: 1831] [UniProtKB: P29323]
ChEMBL Equilibrium binding constant for EPH receptor B2 B 4.71 pKd 19500 nM Kd J Med Chem (2005) 48: 3221-3230 [PMID:15857128]
ChEMBL Inhibition of EPH receptor B2 using ELISA B 4.56 pIC50 27500 nM IC50 J Med Chem (2005) 48: 3221-3230 [PMID:15857128]
platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619]
ChEMBL Inhibition Assay: Inhibition of various kinase enzyme. B 5.43 pIC50 3750 nM IC50 US-9422297-B2. Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof (2016)
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3337] [GtoPdb: 1813] [UniProtKB: P35918]
ChEMBL Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) B 6.1 pIC50 794.33 nM IC50 J Med Chem (2000) 43: 3020-3032 [PMID:10956210]
GtoPdb - - 6.1 pIC50 794 nM IC50 J Med Chem (2000) 43: 3020-32 [PMID:10956210]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]