ChEMBL ligand: CHEMBL259551 (FR-180204)
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] There should be some charts here, you may need to enable JavaScript!
mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
mitogen-activated protein kinase 3/MAP kinase ERK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3385] [GtoPdb: 1494] [UniProtKB: P27361]
GtoPdb	-	-	6.39	pKi	410	nM	Ki	Biochem Biophys Res Commun (2005) 336: 357-63 [PMID:16139248]
ChEMBL	Inhibition of ERK1	B	6.51	pKi	310	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL	Binding affinity to ERK1	B	6.51	pKi	310	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
mitogen-activated protein kinase 1/MAP kinase ERK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4040] [GtoPdb: 1495] [UniProtKB: P28482]
ChEMBL	Binding affinity to ERK2 (unknown origin) by isothermal titration calorimetry	B	6.07	pKd	850	nM	Kd	J Med Chem (2013) 56: 2155-2159 [PMID:23419007]
ChEMBL	Inhibition of ERK2	B	6.51	pKi	310	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
ChEMBL	Binding affinity to ERK2	B	6.51	pKi	310	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
GtoPdb	-	-	6.85	pKi	140	nM	Ki	Biochem Biophys Res Commun (2005) 336: 357-63 [PMID:16139248]
ChEMBL	Inhibitory activity against human ERK2	B	5.72	pIC50	1900	nM	IC50	Bioorg Med Chem Lett (2006) 16: 55-58 [PMID:16242327]
ChEMBL	Inhibition of phosphorylated ERK2 (unknown origin) using myelin basic protein as substrate after 2 hrs in presence of ATP by ADP-glo assay	B	5.92	pIC50	1200	nM	IC50	ACS Med Chem Lett (2017) 8: 726-731 [PMID:28740606]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL	Inhibition of p38alpha	B	6.51	pKi	310	nM	Ki	Proc Natl Acad Sci U S A (2007) 104: 20523-20528 [PMID:18077363]
mitogen-activated protein kinase 6/Mitogen-activated protein kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5121] [GtoPdb: 2092] [UniProtKB: Q16659]
ChEMBL	Binding affinity to LPP-dephosphorylated recombinant wild-type ERK3 (9 to 327 residues) (unknown origin) expressed in Escherichia coli by microscale thermophoresis assay	B	5	pKd	>10000	nM	Kd	Bioorg Med Chem Lett (2020) 30: 127551-127551 [PMID:32927028]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]