compound 3 [PMID: 21105727] [Ligand Id: 6223] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1630806 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu2 receptor/Metabotropic glutamate receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5137] [GtoPdb: 290] [UniProtKB: Q14416] | ||||||||
| GtoPdb | - | - | 6.22 | pKi | 600 | nM | Ki | J Med Chem (2010) 53: 8775-9 [PMID:21105727] |
| ChEMBL | Binding affinity to GFP tagged human mGluR2 containing truncated N-terminal region expressed in HEK cells by FRET assay | B | 6.22 | pKi | 600 | nM | Ki | J Med Chem (2010) 53: 8775-8779 [PMID:21105727] |
| GtoPdb | - | - | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2010) 53: 8775-9 [PMID:21105727] |
| ChEMBL | Negative allosteric modulator activity at human mGluR2 expressed in HEK cells in presence of glutamate EC80 concentration by Ca2+ functional assay | F | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2010) 53: 8775-8779 [PMID:21105727] |
| mGlu3 receptor/Metabotropic glutamate receptor 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2888] [GtoPdb: 291] [UniProtKB: Q14832] | ||||||||
| ChEMBL | Positive allosteric modulator activity at human mGluR3 expressed in HEK cells in presence of glutamate EC10 concentration by Ca2+ functional assay | F | 5.05 | pEC50 | 8900 | nM | EC50 | J Med Chem (2010) 53: 8775-8779 [PMID:21105727] |
| GtoPdb | - | - | 5.1 | pEC50 | 8900 | nM | EC50 | J Med Chem (2010) 53: 8775-9 [PMID:21105727] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
