compound 11 [PMID: 20638279] [Ligand Id: 6235] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1209431 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833] | ||||||||
| ChEMBL | Agonist activity at human mGluR4 expressed in CHO-K1 cells | F | 4.52 | pEC50 | >30000 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4901-4905 [PMID:20638279] |
| GtoPdb | - | - | 6 | pEC50 | 1000 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4901-5 [PMID:20638279] |
| ChEMBL | Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation after 1 hr by fluorescence assay | F | 6 | pEC50 | 1000 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4901-4905 [PMID:20638279] |
| ChEMBL | Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells assessed as potentiation of glutamate-induced calcium mobilization after 1 hr by FLIPR assay | F | 6 | pEC50 | 1000 | nM | EC50 | J Med Chem (2011) 54: 5070-5081 [PMID:21688779] |
| mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423] | ||||||||
| ChEMBL | Positive allosteric modulation of rat mGluR4 expressed in CHO-K1 cells | B | 6 | pEC50 | 1000 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4901-4905 [PMID:20638279] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| ChEMBL | Negative allosteric modulation of human mGluR5 expressed in CHO-K1 cells | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4901-4905 [PMID:20638279] |
| ChEMBL | Positive allosteric modulation of human mGluR5 expressed in CHO-K1 cells | B | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4901-4905 [PMID:20638279] |
| ChEMBL | Agonist activity at human mGluR5 expressed in CHO-K1 cells in absence of glutamate | F | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 4901-4905 [PMID:20638279] |
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2564] [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| ChEMBL | Negative allosteric modulation of rat mGluR5 expressed in CHO-K1 cells | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4901-4905 [PMID:20638279] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
