enalapril [Ligand Id: 6322] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL578 (C09AA02, Enalapril, Lexxel, Olinapril, Vaseretic, Vasotec) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| GtoPdb | - | - | 4.3 | pIC50 | 50000 | nM | IC50 | J Cardiovasc Pharmacol (1994) 23 Suppl 4: S11-5 [PMID:7527095] |
| ChEMBL | Compound tested in vitro for inhibition of Angiotensin I converting enzyme | B | 5.9 | pIC50 | 1273 | nM | IC50 | J Med Chem (1989) 32: 1600-1606 [PMID:2544729] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venom | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2002) 45: 5609-5616 [PMID:12477342] |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in Hog plasma | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
| ChEMBL | Compound was tested for its inhibitory potency against Angiotensin I converting enzyme | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1991) 34: 511-517 [PMID:1995872] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1985) 28: 1291-1295 [PMID:2993618] |
| ChEMBL | Inhibition of guinea pig angiotensin I converting enzyme | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1986) 29: 1953-1961 [PMID:3020249] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (1985) 28: 1603-1606 [PMID:2999394] |
| ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 8.35 | pIC50 | 4.5 | nM | IC50 | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | In vitro inhibition against angiotensin converting enzyme (ACE) | B | 8.92 | pIC50 | 1.2 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2673-2676 |
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme activity in rabbit lung | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (1986) 29: 784-796 [PMID:3009814] |
| ChEMBL | In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3 | B | 5.1 | pIC50 | 8000 | nM | IC50 | J Med Chem (1985) 28: 57-66 [PMID:2981324] |
| ChEMBL | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) | B | 5.48 | pIC50 | 3330 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in rabbit lung | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
| ChEMBL | Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method | B | 6.91 | pIC50 | 123 | nM | IC50 | Bioorg Med Chem (2015) 23: 3526-3533 [PMID:25922179] |
| ChEMBL | Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro) | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1994) 37: 1823-1832 [PMID:8021921] |
| Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
| ChEMBL | Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate. | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1987) 30: 992-998 [PMID:3035180] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
