benazepril [Ligand Id: 6374] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL838 (Benazepril, Benazepril sandoz, Briem, C09AA07, CGS-14824A, Cibacene, Cibacen ws, Forteekor, Lotensin, Lotrel) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| GtoPdb | - | - | 8.8 | pIC50 | 1.7 | nM | IC50 | J Med Chem (1985) 28: 1603-6 [PMID:2999394] |
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins | B | 6.67 | pIC50 | 212 | nM | IC50 | Bioorg Med Chem (2013) 21: 4485-4493 [PMID:23777825] |
| ChEMBL | Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2015) 23: 3526-3533 [PMID:25922179] |
| ChEMBL | Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro) | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1994) 37: 1823-1832 [PMID:8021921] |
| Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (1985) 28: 1603-1606 [PMID:2999394] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
