ChEMBL ligand: CHEMBL231779 (Apixaban, BMS-562247, BMS-562247-01, Eliquis)
coagulation factor X/Coagulation factor X in Human [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] Coagulation factor X in Rabbit [ChEMBL: CHEMBL5062] [UniProtKB: O19045] There should be some charts here, you may need to enable JavaScript!
coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742]
ChEMBL	Inhibition of human factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2007) 17: 4419-4427 [PMID:17588746]
ChEMBL	Binding affinity to human F10a	B	10.1	pKi	0.08	nM	Ki	J Med Chem (2007) 50: 5339-5356 [PMID:17914785]
ChEMBL	Inhibition of human factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2845-2849 [PMID:18424044]
ChEMBL	Inhibition of Factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2179-2185 [PMID:19297154]
ChEMBL	Binding affinity to human coagulation factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2009) 19: 462-468 [PMID:19046881]
ChEMBL	Inhibition of human factor 10a	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1373-1377 [PMID:20100660]
ChEMBL	Inhibition of factor 10a	B	10.1	pKi	0.08	nM	Ki	J Med Chem (2010) 53: 6243-6274 [PMID:20503967]
ChEMBL	Inhibition of purified human factor Xa	B	10.1	pKi	0.08	nM	Ki	Bioorg Med Chem Lett (2014) 24: 3341-3345 [PMID:24951330]
GtoPdb	-	-	10.1	pKi	0.08	nM	Ki	J Thromb Haemost (2008) 6: 820-9 [PMID:18315548]
ChEMBL	Inhibition of human coagulation factor 10a assessed as reduction in p-nitroaniline cleavage from pefachrome substrate preincubated for 10 mins followed by substrate addition measured after 20 mins	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem (2016) 24: 5646-5661 [PMID:27663548]
ChEMBL	Inhibition of human F10a assessed as decrease in p-nitroaniline cleavage from pefachrome F10a preincubated for 10 mins followed by substrate addition measured after 20 mins	B	6.68	pIC50	210	nM	IC50	Bioorg Med Chem (2017) 25: 2800-2810 [PMID:28389110]
Coagulation factor X in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5062] [UniProtKB: O19045]
ChEMBL	Binding affinity to rabbit F10a	B	9.77	pKi	0.17	nM	Ki	J Med Chem (2007) 50: 5339-5356 [PMID:17914785]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL	Inhibition of human thrombin	B	5.51	pKi	3100	nM	Ki	J Med Chem (2007) 50: 5339-5356 [PMID:17914785]
ChEMBL	Inhibition of human factor 2a	B	5.51	pKi	3100	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1373-1377 [PMID:20100660]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]