cipemastat [Ligand Id: 6466] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL115653 (Cipemastat, RO-32-03555, RO 32-3555/000, RO-323555000, Trocade) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Binding affinity to recombinant TACE | B | 6.64 | pKi | 230 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
| ChEMBL | Inhibition of LPS/interferon gamma-stimulated TNFalpha release from HPBMC | F | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
| ChEMBL | Inhibition of TACE | B | 6.64 | pIC50 | 230.3 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of Matrix metalloprotease-1 (MMP1) | B | 5.15 | pKi | 7000 | nM | Ki | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
| GtoPdb | - | - | 8.5 | pKi | 3 | nM | Ki | Ann Rheum Dis (2001) 60 Suppl 3: iii62-7 [PMID:11890658] |
| ChEMBL | Inhibition of matrix metalloprotease-1 (MMP-1). | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | Binding affinity to recombinant MMP1 | B | 9.52 | pKi | 0.3 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
| ChEMBL | Inhibition of MMP1 | B | 8.64 | pIC50 | 2.3 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-13 (MMP-13). | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | Binding affinity to recombinant MMP13 | B | 9 | pKi | 1 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
| ChEMBL | Inhibition of MMP13 assessed as dissociation constant | B | 9.28 | pKi | 0.53 | nM | Ki | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
| ChEMBL | Inhibition of MMP13 in presence of 1% bovine serum albumin | B | 8.33 | pIC50 | 4.7 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
| ChEMBL | Inhibition of MMP13 | B | 8.46 | pIC50 | 3.5 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
| ChEMBL | Inhibitory activity against matrix metalloprotease-13 (MMP13) | B | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of MMP14 | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-2 (MMP-2). | B | 6.81 | pKi | 154 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | Inhibitory activity against matrix metalloprotease-2 (MMP2) | B | 6.81 | pIC50 | 154 | nM | IC50 | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-3 (MMP-3). | B | 6.28 | pKi | 527 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | Binding affinity to recombinant MMP3 | B | 7.25 | pKi | 56 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 2632-2636 [PMID:16516469] |
| ChEMBL | Inhibitory activity against matrix metalloprotease-3 (MMP3) | B | 6.28 | pIC50 | 527 | nM | IC50 | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
| ChEMBL | Inhibition of MMP3 | B | 7.06 | pIC50 | 87 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Inhibition of MMP7 | B | 7.73 | pIC50 | 18.5 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-8 (MMP-8). | B | 8.4 | pKi | 4 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of matrix metalloprotease-9 (MMP-9). | B | 7.23 | pKi | 59 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | Inhibitory activity against matrix metalloprotease-9 (MMP9) | B | 7.24 | pIC50 | 58 | nM | IC50 | J Med Chem (2003) 46: 3840-3852 [PMID:12930146] |
| ChEMBL | Inhibition of MMP9 | B | 8.62 | pIC50 | 2.4 | nM | IC50 | J Med Chem (2009) 52: 3523-3538 [PMID:19422229] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
