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ChEMBL ligand: CHEMBL434492 (Candoxatrilat, Candoxatril diacid, UK-73,967, UK-73967) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Neutral endopeptidase/Neprilysin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944] [GtoPdb: 1611] [UniProtKB: P08473] | ||||||||
GtoPdb | - | - | 7.6 | pIC50 | 28 | nM | IC50 | J Med Chem (2000) 43: 305-41 [PMID:10669559] |
ChEMBL | Inhibition of neutral endopeptidase | B | 8.11 | pIC50 | 7.8 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3404-3406 [PMID:21515054] |
Neutral endopeptidase/Neprilysin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861] | ||||||||
ChEMBL | The compound was tested for its inhibitory activity against neutral endopeptidase (EC.3.4.24.111) in rat kidney | B | 7.42 | pIC50 | 38 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 825-830 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]