fasidotrilat [Ligand Id: 6502] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL325055 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| GtoPdb | - | - | 8 | pKi | 9.8 | nM | Ki | Med Chem (2005) 1: 71-104 [PMID:16789888] |
| ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 8.01 | pKi | 9.8 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| Neutral endopeptidase in Human [GtoPdb: 1611] [UniProtKB: P08473] | ||||||||
| GtoPdb | - | - | 8.3 | pKi | 5.6 | nM | Ki | Med Chem (2005) 1: 321-6 [PMID:16789889] |
| Neutral endopeptidase/Neprilysin in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3369] [GtoPdb: 1611] [UniProtKB: P07861] | ||||||||
| ChEMBL | Inhibitory activity against neutral Endopeptidase | B | 8.25 | pKi | 5.6 | nM | Ki | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
