compound 1 [PMID: 11425539] [Ligand Id: 6542] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL47394 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin G/Cathepsin G in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4071] [GtoPdb: 2348] [UniProtKB: P08311] | ||||||||
| GtoPdb | - | - | 9.4 | pIC50 | 0.39 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-4 [PMID:11425539] |
| ChEMBL | Compound was evaluated for its inhibitory activity against human cathepsin G | B | 9.41 | pIC50 | 0.39 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
| chymase 1/Chymase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4068] [GtoPdb: 2340] [UniProtKB: P23946] | ||||||||
| ChEMBL | Compound was evaluated for its inhibitory activity against human Serine protease chymase | B | 8.4 | pIC50 | 4 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
| chymotrypsin C/Chymotrypsin C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2386] [GtoPdb: 2341] [UniProtKB: Q99895] | ||||||||
| ChEMBL | Compound was evaluated for its inhibitory activity against bovine pancreatic alpha-chymotrypsin | B | 9.16 | pIC50 | 0.69 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
| elastase, neutrophil expressed/Leukocyte elastase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL248] [GtoPdb: 2358] [UniProtKB: P08246] | ||||||||
| ChEMBL | Compound was evaluated for its inhibitory activity against human neutrophil elastase | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
| plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] | ||||||||
| ChEMBL | Compound was evaluated for its inhibitory activity against human plasmin | B | 5.54 | pIC50 | 2900 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
| coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
| ChEMBL | Compound was evaluated for its inhibitory activity against human thrombin | B | 7.14 | pIC50 | 72 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
| Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760] | ||||||||
| ChEMBL | Compound was evaluated for its inhibitory activity against bovine pancreatic trypsin | B | 7.41 | pIC50 | 39 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1691-1694 [PMID:11425539] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
