compound 2 [PMID: 8410973] [Ligand Id: 6566] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL313773 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] | ||||||||
| ChEMBL | Binding affinity against human cathepsin D | B | 8.49 | pKi | 3.2 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
| cathepsin E/Cathepsin E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091] | ||||||||
| GtoPdb | - | - | 10 | pKi | 0.1 | nM | Ki | J Med Chem (1993) 36: 2614-20 [PMID:8410973] |
| ChEMBL | Binding affinity against human cathepsin E | B | 10 | pKi | 0.1 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
| pepsinogen A5/Pepsin A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3295] [GtoPdb: 2390] [UniProtKB: P0DJD9] | ||||||||
| ChEMBL | Binding affinity against human pepsin | B | 7.57 | pKi | 27 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
| progastricsin/Pepsinogen C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2136] [GtoPdb: 2391] [UniProtKB: P20142] | ||||||||
| ChEMBL | Binding affinity against human gastricsin | B | 7.89 | pKi | 13 | nM | Ki | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
| renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] | ||||||||
| ChEMBL | Inhibitory activity against monkey renin | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Med Chem (1993) 36: 2614-2620 [PMID:8410973] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
