eptifibatide [Ligand Id: 6585] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1174 (Eptifibatide, Integrelin, Integrilin) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514] | ||||||||
| ChEMBL | Inhibition of fibrinogen binding to alpha IIb beta-3 integrin using thrombin inhibitor PPACK as anticoagulant | F | 6.24 | pIC50 | 570 | nM | IC50 | J Med Chem (2000) 43: 3453-3473 [PMID:10999999] |
| ChEMBL | Inhibition of human platelet aggregation collected with sodium citrate as anticoagulant | F | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (2000) 43: 3453-3473 [PMID:10999999] |
| integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907598] [GtoPdb: 2457, 2453] [UniProtKB: P05106, P06756] | ||||||||
| ChEMBL | Inhibition of human integrin alphavbeta3 (unknown origin) | B | 6.92 | pKd | 120 | nM | Kd | J Med Chem (2020) 63: 5675-5696 [PMID:31999923] |
| integrin αIIbβ3 in Human [GtoPdb: 2579] | ||||||||
| GtoPdb | inhibition of human platelet aggregation. The IC50 varies according to the anti-coagulant used during blood collection. | - | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (2000) 43: 3453-73 [PMID:10999999] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
