physostigmine [Ligand Id: 6598] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL94 (Cogmine, Eserin, Eserine, Eserinum, MCV-4484, NSC-30782, (-)-physostigmine, Physostigmine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in Torpedo californica | B | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | Inhibition of Pacific electric ray AChE using acetylthiocholine iodide as substrate after 60 mins by Ellman's method | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem (2014) 22: 3341-3350 [PMID:24835788] |
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Tested for in vitro inhibition of acetylcholinesterase | B | 6 | pKi | 1000 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 1131-1132 |
| ChEMBL | Time dependent inhibition of Electric eel AChE assessed as stability constants of inhibitor-enzyme complex using acetylthiocholine as substrate after 60 mins | B | 7.47 | pKi | 34 | nM | Ki | ACS Med Chem Lett (2012) 3: 914-919 [PMID:24900407] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in electric eel | B | 4.28 | pIC50 | 53000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of electric eel AChE | B | 5.82 | pIC50 | 1500 | nM | IC50 | J Nat Prod (1996) 59: 890-893 |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured for 15 mins by Ellman's method relative to control | B | 5.93 | pIC50 | 1170 | nM | IC50 | RSC Med Chem (2020) 11: 518-527 [PMID:33479653] |
| ChEMBL | Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assay | B | 6.56 | pIC50 | 275 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 861-864 |
| ChEMBL | Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide as substrate measured after 30 mins by Ellman's microplate assay | B | 6.8 | pIC50 | 160 | nM | IC50 | Bioorg Med Chem (2016) 24: 4464-4469 [PMID:27492195] |
| ChEMBL | Inhibition of electric eel AchE by Ellman's method | B | 6.99 | pIC50 | 103 | nM | IC50 | J Med Chem (2008) 51: 6400-6409 [PMID:18817366] |
| ChEMBL | Inhibition of electric eel AChE using ATC iodide substrate by DTNB based assay | B | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem (2014) 22: 5020-5034 [PMID:25059502] |
| ChEMBL | Inhibition of Electric eel AChE using acetylthiocholine as substrate after 2 mins | B | 7.05 | pIC50 | 90 | nM | IC50 | ACS Med Chem Lett (2012) 3: 914-919 [PMID:24900407] |
| ChEMBL | In vitro inhibitory activity against acetylcholinesterase from electric eel | B | 7.21 | pIC50 | 61 | nM | IC50 | J Med Chem (1988) 31: 2297-2300 [PMID:3193422] |
| ChEMBL | Inhibition of electric eel AChE type 6S | B | 7.28 | pIC50 | 53 | nM | IC50 | J Med Chem (2010) 53: 1190-1199 [PMID:20067290] |
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in electric eel | B | 7.34 | pIC50 | 46 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | Inhibition of electric eel AChE by modified Ellman method | B | 7.39 | pIC50 | 41 | nM | IC50 | J Nat Prod (2003) 66: 739-742 [PMID:12828454] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 7.39 | pIC50 | 41 | nM | IC50 | J Nat Prod (2001) 64: 842-844 [PMID:11421762] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Eur J Med Chem (2017) 138: 396-406 [PMID:28688279] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in electric eel | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of electric eel AChE incubated for 15 mins by Ellman's method | B | 8.11 | pIC50 | 7.8 | nM | IC50 | J Nat Prod (2019) 82: 2627-2637 [PMID:31433188] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 8.11 | pIC50 | 7.7 | nM | IC50 | Eur J Med Chem (2014) 81: 15-21 [PMID:24819955] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by Ellman's method | B | 8.52 | pIC50 | 3 | nM | IC50 | J Nat Prod (2019) 82: 2489-2500 [PMID:31429569] |
| ChEMBL | Inhibitory activity against acetylcholinesterase as a prodrug was demonstarted | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 123-126 |
| Acetylcholinesterase in Chicken (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227914] [UniProtKB: P36196] | ||||||||
| ChEMBL | Inhibition of acetylcholine esterase in chicken biventer cervicis muscle assessed as rate of acetylcholine hydrolysis by Ellman's method | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1979) 22: 117-119 [PMID:423175] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of human AChE by Ellmans test | B | 1.45 | pIC50 | 1.45 | - | logIC50 | J Med Chem (2010) 53: 6490-6505 [PMID:20684567] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in erythrocyte | B | 4.6 | pIC50 | 25000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in cortex | B | 4.66 | pIC50 | 22000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of recombinant human AChE | B | 4.85 | pIC50 | 14000 | nM | IC50 | J Med Chem (2005) 48: 4444-4456 [PMID:15974596] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine as substrate preincubated for 30 mins followed by substrate addition and measured after 2 mins by Ellman's method | B | 6.27 | pIC50 | 538 | nM | IC50 | J Nat Prod (2020) 83: 1424-1431 [PMID:32239935] |
| ChEMBL | Inhibition of AChE | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of AChE | B | 6.31 | pIC50 | 493.17 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2021) 51: 128374-128374 [PMID:34555506] |
| ChEMBL | DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) | B | 6.76 | pIC50 | 175 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition measured after 10 mins by Ellman's method | B | 6.8 | pIC50 | 160 | nM | IC50 | Medchemcomm (2012) 3: 213-218 |
| ChEMBL | Inhibition of human erythrocyte AChE assessed as acetylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry | B | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem (2012) 20: 2595-2602 [PMID:22445674] |
| ChEMBL | In vitro inhibitory activity against human acetylcholinesterase | F | 6.89 | pIC50 | 128 | nM | IC50 | J Med Chem (1994) 37: 1996-2000 [PMID:8027982] |
| ChEMBL | Concentration required to inhibit acetylcholinesterase isolated from human erythrocytes | B | 6.89 | pIC50 | 128 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 47-50 |
| ChEMBL | In vitro inhibitory activity against human AchE (Acetylcholinesterase) | B | 6.89 | pIC50 | 128 | nM | IC50 | J Med Chem (1992) 35: 1429-1434 [PMID:1573636] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 30 mins by Ellman's microplate assay | B | 7.1 | pIC50 | 80 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3785-3792 [PMID:27236720] |
| ChEMBL | Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate measured after 30 mins by Ellman's method | B | 7.1 | pIC50 | 80 | nM | IC50 | Eur J Med Chem (2020) 206: 112718-112718 [PMID:32861919] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by spectrophotometric based Ellman's method | B | 7.2 | pIC50 | 63 | nM | IC50 | J Nat Prod (2020) 83: 1359-1367 [PMID:32309949] |
| ChEMBL | Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assay | B | 7.21 | pIC50 | 61 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 861-864 |
| ChEMBL | Inhibition acetylcholinesterase (AChE) enzyme. | B | 7.24 | pIC50 | 57.02 | nM | IC50 | J Med Chem (1997) 40: 4360-4371 [PMID:9435905] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase | B | 7.24 | pIC50 | 57 | nM | IC50 | J Med Chem (1996) 39: 5064-5071 [PMID:8978837] |
| ChEMBL | Inhibition of human AChE by Ellmans test | B | 7.25 | pIC50 | 56.7 | nM | IC50 | J Med Chem (2010) 53: 6490-6505 [PMID:20684567] |
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in human erythrocytes | B | 7.33 | pIC50 | 47 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | In vitro inhibition of human acetylcholinesterase. | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1992) 35: 3141-3147 [PMID:1507203] |
| ChEMBL | The compound was evaluated for the inhibition of human Acetylcholinesterase | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1992) 35: 1102-1108 [PMID:1552502] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetyl thiocholine iodide as substrate after 30 mins by Ellman's method | B | 7.4 | pIC50 | 40 | nM | IC50 | Med Chem Res (2013) null: 1-12 |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 30 mins before substrate addition measured after 30 mins by Ellman method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2015) 23: 6014-6024 [PMID:26189031] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in erythrocyte | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of human acetylcholinesterase using acetylcholine iodide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 mins by Ellman's spectrophotometric method | B | 7.49 | pIC50 | 32 | nM | IC50 | J Med Chem (2016) 59: 2067-2082 [PMID:26886849] |
| ChEMBL | Inhibitory activity against Acetylcholinesterase in cortex | B | 7.51 | pIC50 | 31 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibitory concentration against acetylcholinesterase | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2711-2715 [PMID:15878275] |
| ChEMBL | Inhibition of Acetylcholinesterase (AChE) from human RBC | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 2077-2080 |
| ChEMBL | In vitro inhibition of human erythrocyte acetylcholinesterase. | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2001) 44: 4062-4071 [PMID:11708910] |
| ChEMBL | Anticholinesterase activity against human erythrocyte AChE | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibitory concentration against human erythrocyte Acetylcholinesterase | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Inhibition of human acetylcholinesterase from erythrocytes (RBC) | B | 7.55 | pIC50 | 27.9 | nM | IC50 | J Med Chem (1997) 40: 2895-2901 [PMID:9288171] |
| ChEMBL | Anticholinesterase activity against erythrocyte acetylcholinesterase (AChE) in humans. | B | 7.55 | pIC50 | 27.9 | nM | IC50 | J Med Chem (1998) 41: 2371-2379 [PMID:9632370] |
| ChEMBL | Inhibition of human whole RBC AChE pretreated for 30 mins by Ellman technique | B | 7.55 | pIC50 | 27.9 | nM | IC50 | Bioorg Med Chem (2010) 18: 4687-4693 [PMID:20627738] |
| ChEMBL | Evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytes | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (1994) 37: 2721-2734 [PMID:8064800] |
| ChEMBL | In vitro inhibition of Acetylcholinesterase from human erythrocytes | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (1995) 38: 2802-2808 [PMID:7636841] |
| ChEMBL | Inhibition against Acetylcholinesterase (AChE) | B | 7.72 | pIC50 | 18.97 | nM | IC50 | J Med Chem (1996) 39: 380-387 [PMID:8558505] |
| ChEMBL | Concentration required to inhibit 50% of Acetylcholinesterase obtained from human erythrocytes was determined in vitro | B | 7.72 | pIC50 | 18.9 | nM | IC50 | J Med Chem (1995) 38: 1084-1089 [PMID:7707311] |
| ChEMBL | Inhibitory activity against acetylcholinesterase in human erythrocytes | B | 7.75 | pIC50 | 17.78 | nM | IC50 | J Med Chem (2001) 44: 105-109 [PMID:11141093] |
| ChEMBL | Inhibitory concentration against acetylcholinesterase from human erythrocytes | B | 7.75 | pIC50 | 17.78 | nM | IC50 | J Med Chem (2003) 46: 954-966 [PMID:12620072] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 7.8 | pIC50 | 16 | nM | IC50 | Eur J Med Chem (2022) 229: 114044-114044 [PMID:34923430] |
| GtoPdb | - | - | 7.8 | pIC50 | - | - | - | J Med Chem (2006) 49: 2174-85 [PMID:16570913] |
| ChEMBL | Inhibition of acetylcholinesterase (AChE) of human erythrocytes | B | 7.85 | pIC50 | 14.13 | nM | IC50 | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | In vitro inhibition of human erythrocyte Acetylcholinesterase. | B | 7.85 | pIC50 | 14.1 | nM | IC50 | J Med Chem (2001) 44: 3810-3820 [PMID:11689067] |
| ChEMBL | Inhibition of human recombinant AChE | B | 7.87 | pIC50 | 13.49 | nM | IC50 | J Med Chem (2004) 47: 6490-6498 [PMID:15588084] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylcholine iodide as substrate preincubated for 15 mins prior to substrate addition by spectrophotometric analysis | B | 8.54 | pIC50 | 2.9 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 4248-4252 [PMID:23746477] |
| ChEMBL | In vitro inhibitory activity against acetylcholinesterase | B | 9.37 | pIC50 | 0.43 | nM | IC50 | J Med Chem (1992) 35: 584-589 [PMID:1738151] |
| Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
| ChEMBL | Inhibition of bovine AChE by Elman's method | B | 5.59 | pIC50 | 2580 | nM | IC50 | Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490] |
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in bovine brain | B | 6.84 | pIC50 | 146 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | Compound was evaluated for the inhibition of acetylcholinesterase (AChE) in bovine erythrocytes | B | 6.91 | pIC50 | 123 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 575-580 [PMID:9871563] |
| ChEMBL | Concentration required to inhibit hydrolytic activity of Acetylcholinesterase by 50% | B | 7.52 | pIC50 | 30 | nM | IC50 | J Med Chem (1991) 34: 1582-1584 [PMID:2033583] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836] | ||||||||
| ChEMBL | Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1718-1720 [PMID:20137934] |
| ChEMBL | Inhibition of mouse brain AChE after 1 hr by modified Ellman's colorimetric method | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1721-1723 [PMID:20137941] |
| ChEMBL | In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate. | B | 9.16 | pIC50 | 0.69 | nM | IC50 | J Med Chem (1992) 35: 4542-4548 [PMID:1469686] |
| ChEMBL | Inhibitory activity against acetylcholinesterase | B | 9.17 | pIC50 | 0.68 | nM | IC50 | J Med Chem (1995) 38: 4821-4829 [PMID:7490731] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] | ||||||||
| ChEMBL | Inhibitory activity against acetylcholine esterase (AChE) | B | 6.72 | pIC50 | 190 | nM | IC50 | J Med Chem (1994) 37: 689-695 [PMID:8126709] |
| ChEMBL | In vitro inhibitory effect on rat Acetylcholinesterase | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (1995) 38: 2969-2973 [PMID:7636858] |
| ChEMBL | Inhibition of rat acetylcholinesterase (AChE) | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (1998) 41: 3976-3986 [PMID:9767635] |
| ChEMBL | Inhibition of AChE in Wistar rat brain homogenate using acetylthiocholine iodide as substrate after 0.5 hrs by Ellman's method | B | 7.96 | pIC50 | 11 | nM | IC50 | Bioorg Med Chem (2012) 20: 4901-4914 [PMID:22831800] |
| ChEMBL | Inhibitory concentration against rat brain acetylcholinesterase AChE | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1998) 41: 3976-3986 [PMID:9767635] |
| ChEMBL | Inhibition of rat brain AChE by Ellman's method | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1532-1534 [PMID:20144867] |
| ChEMBL | Inhibitory concentration in vitro and ex vivo for anti-AChE activity in rat brain | B | 9.17 | pIC50 | 0.68 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 871-876 |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of anticholinesterase activity by their ability to inactivate human serum butyrylcholinesterase | B | 5.3 | pKi | 5000 | nM | Ki | J Med Chem (1989) 32: 1522-1528 [PMID:2738887] |
| ChEMBL | Inhibitory activity against Butyrylcholinesterase in cortex | B | 4.59 | pIC50 | 26000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of isolated human BuChE | B | 4.64 | pIC50 | 23000 | nM | IC50 | J Med Chem (2005) 48: 4444-4456 [PMID:15974596] |
| ChEMBL | Inhibitory activity against Butyrylcholinesterase in plasma | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Inhibition of BChE | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of BChE | B | 5.93 | pIC50 | 1164.13 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of BChE (unknown origin) using BCh iodide as substrate preincubated for 15 mins prior to substrate addition measured after 10 mins by Ellman's method | B | 6.03 | pIC50 | 930 | nM | IC50 | Eur J Med Chem (2014) 80: 228-242 [PMID:24780600] |
| ChEMBL | Inhibition of BChE | B | 6.07 | pIC50 | 857 | nM | IC50 | J Nat Prod (2003) 66: 739-742 [PMID:12828454] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyryl thiocholine iodide as substrate after 30 mins by Ellman's method | B | 6.07 | pIC50 | 850 | nM | IC50 | Med Chem Res (2013) null: 1-12 |
| ChEMBL | Inhibition of BuChE (unknown origin) using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 6.07 | pIC50 | 850 | nM | IC50 | Eur J Med Chem (2019) 180: 656-672 [PMID:31352246] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyrylthiocholine chloride as substrate preincubated for 30 mins before substrate addition measured after 30 mins by Ellman method | B | 6.07 | pIC50 | 850 | nM | IC50 | Bioorg Med Chem (2015) 23: 6014-6024 [PMID:26189031] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine chloride as substrate by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2021) 51: 128374-128374 [PMID:34555506] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by spectrophotometric based Ellman's method | B | 6.89 | pIC50 | 130 | nM | IC50 | J Nat Prod (2020) 83: 1359-1367 [PMID:32309949] |
| ChEMBL | Inhibitory activity against Butyrylcholinesterase in cortex | B | 6.89 | pIC50 | 129 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| ChEMBL | Concentration required to inhibit 50% of Butyrylcholinesterase obtained from human serum was determined in vitro | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1995) 38: 1084-1089 [PMID:7707311] |
| ChEMBL | In vitro inhibition of Butyrylcholinesterase from human serum | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1995) 38: 2802-2808 [PMID:7636841] |
| ChEMBL | The compound was evaluated for the inhibition human of Butyrylcholinesterase | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1992) 35: 1102-1108 [PMID:1552502] |
| ChEMBL | In vitro inhibition of human butryl cholinesterase. | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1992) 35: 3141-3147 [PMID:1507203] |
| ChEMBL | Inhibition of human plasma BuchE by Ellman's method | B | 7.55 | pIC50 | 28 | nM | IC50 | J Med Chem (2008) 51: 6400-6409 [PMID:18817366] |
| ChEMBL | Inhibition of human recombinant BChE | B | 7.58 | pIC50 | 26.3 | nM | IC50 | J Med Chem (2004) 47: 6490-6498 [PMID:15588084] |
| ChEMBL | In vitro inhibition of human serum Butyrylcholinesterase. | B | 7.64 | pIC50 | 23.1 | nM | IC50 | J Med Chem (2001) 44: 3810-3820 [PMID:11689067] |
| ChEMBL | Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)] | B | 7.64 | pIC50 | 22.91 | nM | IC50 | J Med Chem (1998) 41: 4186-4189 [PMID:9784091] |
| ChEMBL | Inhibitory concentration against butyrylcholinesterase from human serum | B | 7.64 | pIC50 | 22.91 | nM | IC50 | J Med Chem (2003) 46: 954-966 [PMID:12620072] |
| ChEMBL | Inhibition of BuChE in human liver microsomes | B | 7.72 | pIC50 | 19 | nM | IC50 | J Med Chem (2010) 53: 1190-1199 [PMID:20067290] |
| ChEMBL | Inhibition of human plasma BChE pretreated for 30 mins by Ellman technique | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem (2010) 18: 4687-4693 [PMID:20627738] |
| ChEMBL | Anticholinesterase activity against human plasma BChE | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibitory concentration against human plasma Butyrylcholinesterase | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Inhibition of human Butyrylcholinesterase | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (1997) 40: 2895-2901 [PMID:9288171] |
| ChEMBL | In vitro inhibition of human plasma butyrylcholinesterase. | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (2001) 44: 4062-4071 [PMID:11708910] |
| ChEMBL | Anticholinesterase activity against plasma Butyrylcholinesterase (BChE) in humans. | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (1998) 41: 2371-2379 [PMID:9632370] |
| ChEMBL | Inhibition of BuChE (unknown origin) | B | 7.8 | pIC50 | 16 | nM | IC50 | Eur J Med Chem (2022) 229: 114044-114044 [PMID:34923430] |
| GtoPdb | - | - | 7.8 | pIC50 | - | - | - | J Med Chem (2006) 49: 2174-85 [PMID:16570913] |
| ChEMBL | Inhibitory activity against Butyrylcholinesterase in plasma | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1990) 33: 2311-2319 [PMID:2202827] |
| Butyrylcholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9] | ||||||||
| ChEMBL | Inhibition of (BChE) Butyrylcholinesterase of horse serum | B | 5.33 | pIC50 | 4666.7 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 861-864 |
| ChEMBL | Inhibition of equine BChE assessed as butyrylthiocholine iodide hydrolysis after 10 mins preincubation by spectrophotometry | B | 5.43 | pIC50 | 3700 | nM | IC50 | Bioorg Med Chem (2012) 20: 2595-2602 [PMID:22445674] |
| ChEMBL | Compound was evaluated for the in vitro inhibition of the Butyrylcholinesterase from horse serum | B | 7.14 | pIC50 | 73 | nM | IC50 | J Med Chem (1994) 37: 2721-2734 [PMID:8064800] |
| ChEMBL | Compound was evaluated for its inhibitory concentration against Horse serum Butyrylcholinesterase | B | 7.8 | pIC50 | 16 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2747-2750 [PMID:9873615] |
| butyrylcholinesterase/Butyrylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2528] [GtoPdb: 2471] [UniProtKB: Q03311] | ||||||||
| ChEMBL | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method | B | 6.55 | pIC50 | 280 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1718-1720 [PMID:20137934] |
| ChEMBL | Inhibition of mouse serum BChE after 1 hr by modified Ellman's colorimetric method | B | 6.55 | pIC50 | 280 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1721-1723 [PMID:20137941] |
| Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] | ||||||||
| ChEMBL | Inhibition of BuChE in Wistar rat plasma using acetylthiocholine iodide as substrate after 0.5 hrs by Ellman's method | B | 7.23 | pIC50 | 58.4 | nM | IC50 | Bioorg Med Chem (2012) 20: 4901-4914 [PMID:22831800] |
| ChEMBL | Inhibition of isolated Butyrylcholinesterase (BuChE ) | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1998) 41: 3976-3986 [PMID:9767635] |
| ChEMBL | Butyrylcholinesterase | B | 8.09 | pIC50 | 8.1 | nM | IC50 | J Med Chem (1995) 38: 4821-4829 [PMID:7490731] |
| ChEMBL | In vitro inhibitory concentration against butyrylcholinesterase (BuChE) obtained from rat plasma | B | 8.09 | pIC50 | 8.1 | nM | IC50 | J Med Chem (1992) 35: 4542-4548 [PMID:1469686] |
| ChEMBL | Inhibitory concentration was determined in in vitro for Butyrylcholinesterase in rat plasma | B | 8.09 | pIC50 | 8.1 | nM | IC50 | Bioorg Med Chem Lett (1992) 2: 871-876 |
| ChEMBL | Inhibition of rat plasma BChE by Ellman's method | B | 8.12 | pIC50 | 7.6 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 1532-1534 [PMID:20144867] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Time dependent inhibition of equine serum BChE assessed as stability constants of inhibitor-enzyme complex using acetylthiocholine as substrate after 60 mins | B | 7.39 | pKi | 41 | nM | Ki | ACS Med Chem Lett (2012) 3: 914-919 [PMID:24900407] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490] |
| ChEMBL | Inhibition of horse BChE | B | 6.07 | pIC50 | 857 | nM | IC50 | J Nat Prod (2001) 64: 842-844 [PMID:11421762] |
| ChEMBL | Inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 6.07 | pIC50 | 850 | nM | IC50 | Eur J Med Chem (2017) 138: 396-406 [PMID:28688279] |
| ChEMBL | Inhibition of equine serum BChE preincubated for 15 mins followed by addition of S-butyrylthiocholine chloride as substrate measured after 30 mins by Ellman's microplate assay | B | 6.24 | pIC50 | 580 | nM | IC50 | Bioorg Med Chem (2016) 24: 4464-4469 [PMID:27492195] |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate incubated for 30 mins by Ellman's microplate assay | B | 6.66 | pIC50 | 220 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3785-3792 [PMID:27236720] |
| ChEMBL | Inhibition of equine serum butyrylcholinesterase using butyrylcholine iodide as substrate preincubated for 30 mins followed by substrate addition measured after 2.5 mins by Ellman's spectrophotometric method | B | 7.11 | pIC50 | 78 | nM | IC50 | J Med Chem (2016) 59: 2067-2082 [PMID:26886849] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 7.22 | pIC50 | 60 | nM | IC50 | Eur J Med Chem (2014) 81: 15-21 [PMID:24819955] |
| ChEMBL | Inhibition of equine serum BChE using acetylthiocholine as substrate after 2 mins | B | 7.38 | pIC50 | 42 | nM | IC50 | ACS Med Chem Lett (2012) 3: 914-919 [PMID:24900407] |
| ChEMBL | Inhibition of equine serum BChE using ATC iodide substrate by DTNB based assay | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2014) 22: 5020-5034 [PMID:25059502] |
| ChEMBL | Inhibition of BChE in horse serum using butyrylthiocholine iodide as substrate after 120 mins by Ellman's method | B | 7.85 | pIC50 | 14 | nM | IC50 | Bioorg Med Chem (2014) 22: 3341-3350 [PMID:24835788] |
| CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 6.7 | pIC50 | 200 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3733] [GtoPdb: 13] [UniProtKB: P12657] | ||||||||
| ChEMBL | Binding affinity against mouse muscarinic acetylcholine receptor M1 using cerebral cortex and [3H]pirenzepine | B | 4.43 | pIC50 | 37000 | nM | IC50 | J Med Chem (1992) 35: 3141-3147 [PMID:1507203] |
| ChEMBL | Compound was evaluated for the competitive inhibition of [3H]pirenzepine binding to muscarinic acetylcholine receptor M1 of mouse cerebral cortex | B | 4.43 | pIC50 | 37000 | nM | IC50 | J Med Chem (1992) 35: 1102-1108 [PMID:1552502] |
| Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.2 | pIC50 | 6309.57 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay | F | 5.3 | pIC50 | 5011.87 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
| ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
