bambuterol [Ligand Id: 6601] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL521589 (Bambuterol) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibition of electric eel AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of human blood AChE using acetylthiocholine as substrate | B | 4.52 | pIC50 | 30000 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 4.52 | pIC50 | 30000 | nM | IC50 | Eur J Med Chem (2017) 132: 294-309 [PMID:28371641] |
| ChEMBL | Inhibition of human erythrocytes AChE using S-acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5 | pIC50 | >10000 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of human plasma BuChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 8.37 | pIC50 | 4.29 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
| GtoPdb | - | - | 8.5 | pIC50 | - | - | - | Neurochem Res (2003) 28: 515-22 [PMID:12675140] |
| ChEMBL | Inhibition of human blood BuChE using butyrylthiocholine as substrate | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
| ChEMBL | Inhibition of BuChE (unknown origin) | B | 8.52 | pIC50 | 3 | nM | IC50 | Eur J Med Chem (2017) 132: 294-309 [PMID:28371641] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 6.92 | pIC50 | 119.33 | nM | IC50 | Eur J Med Chem (2017) 126: 61-71 [PMID:27744187] |
| CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.7 | pIC50 | 2000 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
