chroman 28 [Ligand Id: 664] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL415848 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| B1 receptor/Bradykinin B1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663] | ||||||||
| ChEMBL | Antagonist activity at bradykinin B1 receptor assessed as prevention of Lys-desArg9-Bk-induced contraction in human umbilical vein | F | 7.4 | pKd | 39.81 | nM | Kd | J Med Chem (2007) 50: 607-610 [PMID:17243660] |
| ChEMBL | Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D cells | B | 9.11 | pKi | 0.77 | nM | Ki | J Med Chem (2007) 50: 607-610 [PMID:17243660] |
| ChEMBL | Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHOD cells | B | 9.15 | pKi | 0.7 | nM | Ki | J Med Chem (2007) 50: 2200-2212 [PMID:17408249] |
| ChEMBL | Antagonistic activity at human bradykinin B1 receptor expressed in CHO cells assessed as effect on DAK-mediated calcium mobilization | F | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2007) 50: 607-610 [PMID:17243660] |
| ChEMBL | Antagonist activity at human bradykinin B1 receptor expressed in CHOD cells assessed as effect on DAK-induced calcium flux | F | 8.47 | pIC50 | 3.4 | nM | IC50 | J Med Chem (2007) 50: 2200-2212 [PMID:17408249] |
| GtoPdb | - | - | 8.5 | pIC50 | - | - | - | J Med Chem (2007) 50: 607-10 [PMID:17243660] |
| ChEMBL | Antagonistic activity at African green monkey bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization | F | 9.4 | pIC50 | 0.4 | nM | IC50 | J Med Chem (2007) 50: 607-610 [PMID:17243660] |
| Bradykinin B1 receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4087] [UniProtKB: P48748] | ||||||||
| ChEMBL | Antagonistic activity at rabbit bradykinin B1 receptor expressed in CHO-D cells assessed as effect on DAK-mediated calcium mobilization | F | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (2007) 50: 607-610 [PMID:17243660] |
| B1 receptor/Bradykinin B1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4613] [GtoPdb: 41] [UniProtKB: P97583] | ||||||||
| ChEMBL | Antagonistic activity at rat bradykinin B1 receptor assessed as effect on DAK-mediated calcium mobilization | F | 8.4 | pIC50 | 4 | nM | IC50 | J Med Chem (2007) 50: 607-610 [PMID:17243660] |
| GtoPdb | - | - | 8.5 | pIC50 | - | - | - | J Med Chem (2007) 50: 607-10 [PMID:17243660] |
| B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411] | ||||||||
| ChEMBL | Displacement of [3H]bradykinin from human bradykinin B2 receptor expressed in CHO-K1 cells | B | 4.3 | pKi | >50000 | nM | Ki | J Med Chem (2007) 50: 607-610 [PMID:17243660] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
