ChEMBL ligand: CHEMBL189123
B1 receptor/Bradykinin B1 receptor in Human [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663] Bradykinin B1 receptor in Dog [ChEMBL: CHEMBL4724] [UniProtKB: Q9BDQ5] Bradykinin B1 receptor in Rabbit [ChEMBL: CHEMBL4087] [UniProtKB: P48748] B1 receptor/Bradykinin B1 receptor in Rat [ChEMBL: CHEMBL4613] [GtoPdb: 41] [UniProtKB: P97583] There should be some charts here, you may need to enable JavaScript!
B2 receptor/Bradykinin B2 receptor in Human [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
B1 receptor/Bradykinin B1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4308] [GtoPdb: 41] [UniProtKB: P46663]
ChEMBL	Binding affinity to human BK1 receptor Q295 mutant	B	9.05	pKi	0.89	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2791-2795 [PMID:16529929]
ChEMBL	Binding affinity to human BK1 receptor D291 mutant	B	10.31	pKi	0.05	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2791-2795 [PMID:16529929]
ChEMBL	Binding affinity to human BK1 receptor N298 mutant	B	10.42	pKi	0.04	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2791-2795 [PMID:16529929]
ChEMBL	Displacement of [3H]Lys0-des-Arg9-BK at human bradykinin B1 receptor expressed in HEK293 cells	B	10.47	pKi	0.03	nM	Ki	J Med Chem (2010) 53: 5383-5399 [PMID:20369879]
ChEMBL	Binding affinity to human bradykinin B1 receptor	B	10.47	pKi	0.03	nM	Ki	Bioorg Med Chem Lett (2012) 22: 3095-3099 [PMID:22483585]
ChEMBL	Binding affinity to human BK1 receptor	B	10.47	pKi	0.03	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2791-2795 [PMID:16529929]
ChEMBL	Displacement of [3H]DAK from human bradykinin B1 receptor expressed in CHO-D-/aequorin cells by rapid filtration technique	B	10.47	pKi	0.03	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4477-4481 [PMID:18674903]
GtoPdb	-	-	10.5	pKi	-	-	-	J Am Chem Soc (2003) 125: 7516-7 [PMID:12812482]
ChEMBL	Binding affinity to human Bradykinin receptor B1 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay	B	10.52	pKi	0.03	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6045-6048 [PMID:15546726]
ChEMBL	Antagonist activity at human bradykinin B1 receptor expressed in CHO-D-/aequorin cells	F	9.74	pIC50	0.18	nM	IC50	Bioorg Med Chem Lett (2008) 18: 4477-4481 [PMID:18674903]
ChEMBL	Antagonist activity at human bradykinin B1 receptor in human MR5 cells assessed as [3H]inositol phosphate accumulation	F	9.74	pIC50	0.18	nM	IC50	J Med Chem (2010) 53: 5383-5399 [PMID:20369879]
Bradykinin B1 receptor in Dog (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4724] [UniProtKB: Q9BDQ5]
ChEMBL	Antagonist activity at dog bradykinin B1 receptor	F	7.79	pIC50	16.3	nM	IC50	J Med Chem (2010) 53: 5383-5399 [PMID:20369879]
Bradykinin B1 receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4087] [UniProtKB: P48748]
ChEMBL	Inhibition of rabbit bradykinin B1 receptor	B	9.59	pIC50	0.26	nM	IC50	J Med Chem (2010) 53: 5383-5399 [PMID:20369879]
B1 receptor/Bradykinin B1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4613] [GtoPdb: 41] [UniProtKB: P97583]
GtoPdb	-	-	7.2	pKi	-	-	-	J Am Chem Soc (2003) 125: 7516-7 [PMID:12812482]
ChEMBL	Inhibition of rat bradykinin B1 receptor	B	6.79	pIC50	163.5	nM	IC50	J Med Chem (2010) 53: 5383-5399 [PMID:20369879]
B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
ChEMBL	Binding affinity to human Bradykinin receptor B2 over-expressed in transgenic rats was determined by ex vivo receptor occupancy assay	B	5	pKi	>10000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6045-6048 [PMID:15546726]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]