propylthiouracil [Ligand Id: 6650] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1518 (NSC-6498, NSC-70461, Propacil, Propylthiouracil, Prothyran, Thyreostat, Thyreostat ii) |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] | ||||||||
| ChEMBL | Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysis | B | 5.24 | pIC50 | 5700 | nM | IC50 | J Med Chem (2015) 58: 8513-8528 [PMID:26509551] |
| ChEMBL | Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin after 300 secs by spectrophotometric analysis | B | 5.55 | pIC50 | 2810 | nM | IC50 | J Med Chem (2015) 58: 8513-8528 [PMID:26509551] |
| TAS2R38/Taste receptor type 2 member 38 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523248] [GtoPdb: 682] [UniProtKB: P59533] | ||||||||
| GtoPdb | - | - | 5.68 | pEC50 | 2100 | nM | EC50 | Curr Biol (2005) 15: 322-7 [PMID:15723792] |
| ChEMBL | Activity at human TAS2R38 expressed in HEK-293T-Galpha16-gustducin44 cells assessed as effect on calcium response by FLIPR assay | F | 5.7 | pEC50 | 2000 | nM | EC50 | EP-2267129-B1. Bitter taste receptors (null) |
| thyroid peroxidase/Thyroid peroxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1839] [GtoPdb: 2526] [UniProtKB: P07202] | ||||||||
| ChEMBL | Inhibition of TPO (unknown origin) using Amplex Red as substrate assessed as formation of resorufin measured every 20 secs by spectrophotometric analysis | B | 5.47 | pIC50 | 3380 | nM | IC50 | J Med Chem (2015) 58: 8513-8528 [PMID:26509551] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
