ChEMBL ligand: CHEMBL2028850 (HOE-140, Icatibant)
B2 receptor/Bradykinin B2 receptor in Human [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411] B2 receptor in Mouse [GtoPdb: 42] [UniProtKB: P32299] B2 receptor/Bradykinin B2 receptor in Rat [ChEMBL: CHEMBL2501] [GtoPdb: 42] [UniProtKB: P25023] Bradykinin B2 receptor in Guinea pig [ChEMBL: CHEMBL4111] [UniProtKB: O70526] There should be some charts here, you may need to enable JavaScript!
B1 receptor in Human [GtoPdb: 41] [UniProtKB: P46663] B1 receptor in Rat [GtoPdb: 41] [UniProtKB: P97583] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
B2 receptor/Bradykinin B2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3157] [GtoPdb: 42] [UniProtKB: P30411]
ChEMBL	Antagonist effect against bradykinin B2 receptor was determined in rabbit jugular vein	F	9.04	pKd	0.91	nM	Kd	Bioorg Med Chem Lett (1994) 4: 781-784
ChEMBL	Antagonist activity against bradykinin B2 receptor	F	9.55	pKd	0.28	nM	Kd	Bioorg Med Chem Lett (2006) 16: 2387-2390 [PMID:16504505]
ChEMBL	Binding affinity towards Bradykinin receptor B2 in human S34 clone cells	B	9.74	pKi	0.18	nM	Ki	J Med Chem (1996) 39: 1472-1484 [PMID:8691478]
GtoPdb	-	-	10.19	pKi	0.06	nM	Ki	J Med Chem (1999) 42: 4185-92 [PMID:10514288]
ChEMBL	Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligand	B	10.19	pKi	0.06	nM	Ki	J Med Chem (1999) 42: 4185-4192 [PMID:10514288]
ChEMBL	Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement.	B	10.22	pKi	0.06	nM	Ki	J Med Chem (1999) 42: 4193-4201 [PMID:10514289]
ChEMBL	Binding affinity to human bradykinin B2 receptor transfected in CHO cells	B	10.6	pKi	0.03	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2387-2390 [PMID:16504505]
ChEMBL	Concentration required to inhibit specific binding of [3H]BK (1.2 nM) to A-431 cells (human epidermoid carcinoma) which express Bradykinin receptor B2 by 50%.	B	8.48	pIC50	3.3	nM	IC50	J Med Chem (1998) 41: 4062-4079 [PMID:9767643]
ChEMBL	Concentration required to inhibit specific binding of [3H]BK at 1.2 nM to A-431 cells (human epidermoid carcinoma) which express Bradykinin receptor B2 by 50%.	B	8.48	pIC50	3.3	nM	IC50	J Med Chem (1998) 41: 4053-4061 [PMID:9767642]
ChEMBL	Inhibition specific binding of [3H]BK (1.0 nM) to human Bradykinin receptor B2 which was expressed in CHO (Chinese hamster ovary) cells by 50%.	B	9.31	pIC50	0.49	nM	IC50	J Med Chem (1998) 41: 4062-4079 [PMID:9767643]
ChEMBL	In vitro inhibitory activity towards human bradykinin receptor B2 expressed in CHO cells using [3H]BK (1.0 nM) as a radioligand	B	9.31	pIC50	0.49	nM	IC50	J Med Chem (2004) 47: 1617-1630 [PMID:15027853]
GtoPdb	-	-	9.4	pIC50	-	-	-	Mol Pharmacol (1994) 45: 1-8 [PMID:8302267]; Mol Pharmacol (1997) 51: 171-6 [PMID:9203620]
GtoPdb	-	-	8.4	pA2	-	-	-	Br J Pharmacol (1996) 118: 289-94 [PMID:8735629]
B2 receptor in Mouse [GtoPdb: 42] [UniProtKB: P32299]
GtoPdb	-	-	9.6	pKi	-	-	-	Mol Pharmacol (1994) 45: 1-8 [PMID:8302267]
B2 receptor/Bradykinin B2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2501] [GtoPdb: 42] [UniProtKB: P25023]
ChEMBL	In vitro Bradykinin receptor B2 antagonist activity by using rat uterus functional assay	F	9.5	pKd	0.32	nM	Kd	J Med Chem (1996) 39: 1472-1484 [PMID:8691478]
ChEMBL	Binding affinity against rat bradykinin B2 receptors expressed in CHO cells using [3H]bradykinin as radioligand	B	10.11	pKi	0.08	nM	Ki	J Med Chem (1999) 42: 4185-4192 [PMID:10514288]
GtoPdb	-	-	10.3	pKi	-	-	-	Br J Pharmacol (2000) 129: 77-86 [PMID:10694205]
Bradykinin B2 receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4111] [UniProtKB: O70526]
ChEMBL	In vitro binding affinity against bradykinin receptor B2 from guinea pig ileum.	B	9.96	pKi	0.11	nM	Ki	J Med Chem (1993) 36: 1450-1460 [PMID:8388469]
ChEMBL	In vitro antagonistic activity for Bradykinin receptor B2 by guinea pig pulmonary artery assay.	F	8.27	pIC50	5.4	nM	IC50	J Med Chem (1995) 38: 2799-2801 [PMID:7636840]
ChEMBL	In vitro antagonistic activity for Bradykinin receptor B2 by guinea pig ileal membrane receptor assay.	F	8.97	pIC50	1.07	nM	IC50	J Med Chem (1995) 38: 2799-2801 [PMID:7636840]
ChEMBL	Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.	B	10.05	pIC50	0.09	nM	IC50	J Med Chem (1998) 41: 4062-4079 [PMID:9767643]
ChEMBL	Concentration required to inhibit specific binding of [3H]BK at 0.06 nM to Bradykinin receptor B2 in guinea pig ileum membrane preparations by 50%.	B	10.05	pIC50	0.09	nM	IC50	J Med Chem (1998) 41: 4053-4061 [PMID:9767642]
ChEMBL	In vitro inhibitory activity towards bradykinin receptor B2 using [3H]BK (0.06 nM) as a radioligand in guinea pig ileum membrane preparation	B	10.05	pIC50	0.09	nM	IC50	J Med Chem (2004) 47: 1617-1630 [PMID:15027853]
B1 receptor in Human [GtoPdb: 41] [UniProtKB: P46663]
GtoPdb	-	-	7	pKi	-	-	-	Eur J Pharmacol (1999) 374: 423-433 [PMID:10422787]; Br J Pharmacol (1997) 122: 393-9 [PMID:9313952]
B1 receptor in Rat [GtoPdb: 41] [UniProtKB: P97583]
GtoPdb	-	-	6.4	pKi	-	-	-	Eur J Pharmacol (1999) 374: 423-433 [PMID:10422787]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]