ChEMBL ligand: CHEMBL95 (Tacrinal, Tacrine)
nicotinic acetylcholine receptor ε subunit/Acetylcholine receptor protein epsilon chain in Human [ChEMBL: CHEMBL2484] [GtoPdb: 477] [UniProtKB: Q04844] There should be some charts here, you may need to enable JavaScript!
Acetylcholinesterase in Torpedo californica [ChEMBL: CHEMBL4780] [UniProtKB: P04058] Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275] acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] Acetylcholinesterase in Bovine [ChEMBL: CHEMBL4768] [UniProtKB: P23795] acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836] acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] There should be some charts here, you may need to enable JavaScript!
carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141] There should be some charts here, you may need to enable JavaScript!
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] There should be some charts here, you may need to enable JavaScript!
Beta amyloid A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] Butyrylcholinesterase in Equus caballus [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9] butyrylcholinesterase/Butyrylcholinesterase in Mouse [ChEMBL: CHEMBL2528] [GtoPdb: 2471] [UniProtKB: Q03311] Butyrylcholinesterase in Rat [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] There should be some charts here, you may need to enable JavaScript!
CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] There should be some charts here, you may need to enable JavaScript!
CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] There should be some charts here, you may need to enable JavaScript!
choline O-acetyltransferase/Choline acetylase in Rat [ChEMBL: CHEMBL3945] [GtoPdb: 2480] [UniProtKB: P32738] There should be some charts here, you may need to enable JavaScript!
Cholinesterase in Equus caballus [ChEMBL: CHEMBL5763] [UniProtKB: P81908] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] There should be some charts here, you may need to enable JavaScript!
CYP2D6/Cytochrome P450 2D6 in Human [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] There should be some charts here, you may need to enable JavaScript!
DAT/Dopamine transporter in Rat [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977] There should be some charts here, you may need to enable JavaScript!
GluN1/GluN2A/Glutamate NMDA receptor; GRIN1/GRIN2A in Human [ChEMBL: CHEMBL1907604] [GtoPdb: 455, 456] [UniProtKB: Q05586, Q12879] There should be some charts here, you may need to enable JavaScript!
GluN1/GluN2B/Glutamate NMDA receptor; GRIN1/GRIN2B in Human [ChEMBL: CHEMBL1907603] [GtoPdb: 455, 457] [UniProtKB: Q05586, Q13224] There should be some charts here, you may need to enable JavaScript!
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Histamine N-methyltransferase in Rat [ChEMBL: CHEMBL3241] [UniProtKB: Q01984] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase A in Rat [ChEMBL: CHEMBL3358] [UniProtKB: P21396] There should be some charts here, you may need to enable JavaScript!
Monoamine oxidase B in Rat [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643] There should be some charts here, you may need to enable JavaScript!
M1 receptor/Muscarinic acetylcholine receptor M1 in Human [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] M1 receptor/Muscarinic acetylcholine receptor M1 in Mouse [ChEMBL: CHEMBL3733] [GtoPdb: 13] [UniProtKB: P12657] There should be some charts here, you may need to enable JavaScript!
M2 receptor/Muscarinic acetylcholine receptor M2 in Human [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] Muscarinic acetylcholine receptor M2 in Pig [ChEMBL: CHEMBL4781] [UniProtKB: P06199] M2 receptor/Muscarinic acetylcholine receptor M2 in Mouse [ChEMBL: CHEMBL3197] [GtoPdb: 14] [UniProtKB: Q9ERZ4] M2 receptor/Muscarinic acetylcholine receptor M2 in Rat [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α6 subunit/Nicotinic acetylcholine receptor alpha6/alpha3/beta4 in Rat [ChEMBL: CHEMBL3137276] [GtoPdb: 464, 474, 467] [UniProtKB: P04757, P12392, P43143] There should be some charts here, you may need to enable JavaScript!
NET/Norepinephrine transporter in Human [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] Norepinephrine transporter in Rat [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum 3D7 [ChEMBL: CHEMBL2366922] There should be some charts here, you may need to enable JavaScript!
SERT/Serotonin transporter in Rat [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!
Cav2.1/Cav3.1/Cav1.4/Cav3.2/Cav2.2/Cav1.3/Cav1.1/Cav1.2/Cav2.3/Cav3.3/Voltage-gated calcium channel in Human [ChEMBL: CHEMBL2363032] [GtoPdb: 532, 535, 531, 536, 533, 530, 528, 529, 534, 537] [UniProtKB: O00305, O00555, O43497, O60359, O60840, O95180, P54284, P54289, P62955, Q00975, Q01668, Q02641, Q06432, Q08289, Q13698, Q13936, Q15878, Q7Z3S7, Q8IZS8, Q8WXS5, Q9BXT2, Q9NY47, Q9P0X4, Q9UBN1, Q9UF02, Q9Y698] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
nicotinic acetylcholine receptor ε subunit/Acetylcholine receptor protein epsilon chain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2484] [GtoPdb: 477] [UniProtKB: Q04844]
ChEMBL	Inhibition of AChE (unknown origin) by spectrophotometric analysis	B	6.82	pKi	152.28	nM	Ki	Eur J Med Chem (2019) 180: 656-672 [PMID:31352246]
ChEMBL	Inhibition of acetylcholinesterase	B	7.36	pIC50	44	nM	IC50	J Med Chem (2005) 48: 7496-7499 [PMID:16279811]
Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058]
ChEMBL	Inhibition of Torpedo californica AChE	B	7.4	pKi	40	nM	Ki	J Med Chem (2008) 51: 3154-3170 [PMID:18479118]
ChEMBL	Inhibition of Torpedo californica AChE using acetylthiocholine chloride as substrate peincubated for 15 mins followed by substrate addition measured after 5 mins by Ellman's method	B	6.72	pIC50	190	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126880-126880 [PMID:31864798]
ChEMBL	Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate assessed as ROS-induced enzyme inactivation preincubated for 10 mins followed by substrate addition measured every 30 secs for 20 mins in presence of horseradish peroxidase and H2O2	B	6.74	pIC50	183	nM	IC50	Medchemcomm (2011) 2: 406-412
ChEMBL	Inhibition of Torpedo californica AChE by Ellman's method	B	6.8	pIC50	157	nM	IC50	J Med Chem (2007) 50: 5311-5323 [PMID:17902635]
ChEMBL	Inhibition of Torpedo californica AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 1 min interval for 3 mins by Ellman's method	B	7	pIC50	100	nM	IC50	Bioorg Med Chem (2017) 25: 2387-2398 [PMID:28302511]
ChEMBL	Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate preincubated for 10 mins followed by substrate addition measured every 30 secs for 30 mins by Ellmans method	B	7.28	pIC50	52.4	nM	IC50	Medchemcomm (2011) 2: 406-412
ChEMBL	Inhibitory activity against acetylcholinesterase (AChE) from Torpedo californica (Reversible type of inhibition)	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2003) 13: 1825-1827 [PMID:12729674]
ChEMBL	In vitro inhibition of Torpedo californica acetylcholinesterase.	B	7.41	pIC50	39	nM	IC50	J Med Chem (1999) 42: 730-741 [PMID:10052979]
ChEMBL	Inhibition of Pacific electric ray AChE using acetylthiocholine iodide as substrate after 60 mins by Ellman's method	B	7.54	pIC50	29	nM	IC50	Bioorg Med Chem (2014) 22: 3341-3350 [PMID:24835788]
ChEMBL	Inhibition of Torpedo californica AChE by spectrophotometry based Ellman's method	B	7.54	pIC50	29	nM	IC50	Bioorg Med Chem (2014) 22: 3838-3849 [PMID:25017625]
ChEMBL	Inhibition of activity against Torpedo Ray acetylcholinesterase.	B	8.09	pIC50	8.2	nM	IC50	J Med Chem (2001) 44: 3203-3215 [PMID:11563919]
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL	Binding affinity to electric eel AChE after 24 hrs by LC/MS-SIM analysis	B	7.8	pKd	16	nM	Kd	J Med Chem (2018) 61: 9395-9409 [PMID:29873484]
ChEMBL	Non-competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot method	B	6.47	pKi	340	nM	Ki	J Med Chem (2013) 56: 2038-2044 [PMID:23330848]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by Ellman's method	B	7.57	pKi	27	nM	Ki	Eur J Med Chem (2017) 138: 761-773 [PMID:28728108]
ChEMBL	Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 8270-8288 [PMID:16366609]
ChEMBL	Competitive inhibition of electric eel AChE assessed as enzyme-inhibitor complex using p-nitrophenyl acetate as substrate by Lineweaver-Burk plot analysis	B	7.64	pKi	22.9	nM	Ki	Eur J Med Chem (2017) 138: 761-773 [PMID:28728108]
ChEMBL	Inhibition of Electrophorus electricus AChE by Ellman's method	B	7.69	pKi	20.2	nM	Ki	Bioorg Med Chem (2008) 16: 7759-7769 [PMID:18640842]
ChEMBL	Tested for in vitro inhibition of acetylcholinesterase	B	8	pKi	10	nM	Ki	Bioorg Med Chem Lett (1995) 5: 1131-1132
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by addition of substrate measured after 5 mins	B	3.46	pIC50	350000	nM	IC50	Eur J Med Chem (2018) 148: 255-267 [PMID:29466775]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	4.12	pIC50	76500	nM	IC50	Bioorg Med Chem Lett (2021) 49: 128212-128212 [PMID:34153471]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins by Ellman method	B	4.32	pIC50	47410	nM	IC50	Bioorg Med Chem (2015) 23: 2445-2457 [PMID:25868744]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by Ellman's method	B	6.03	pIC50	930	nM	IC50	Medchemcomm (2019) 10: 764-777 [PMID:31191867]
ChEMBL	Inhibition of electric eel AChE using acetylcholine iodide as substrate preincubated for 20 mins by Ellman's method	B	6.05	pIC50	900	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6498-6502 [PMID:22981331]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins prior to substrate addition by Ellman's method	B	6.39	pIC50	410	nM	IC50	Eur J Med Chem (2013) 68: 291-300 [PMID:23988412]
ChEMBL	Non-competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot method	B	6.41	pIC50	386	nM	IC50	J Med Chem (2013) 56: 2038-2044 [PMID:23330848]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method	B	6.43	pIC50	372	nM	IC50	Eur J Med Chem (2016) 107: 219-232 [PMID:26588065]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured for 5 mins by Ellmans method	B	6.43	pIC50	371.5	nM	IC50	Eur J Med Chem (2016) 124: 1026-1040 [PMID:27783974]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mins by Ellman's method	B	6.44	pIC50	365	nM	IC50	Eur J Med Chem (2017) 139: 280-289 [PMID:28803044]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 1 min by Ellman's method	B	6.45	pIC50	356	nM	IC50	Eur J Med Chem (2017) 128: 237-246 [PMID:28189905]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 6 mins by Ellman's method	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2019) 180: 656-672 [PMID:31352246]
ChEMBL	Inhibition of electric eel AChE after 15 mins by DTNB reagent based assay	B	6.5	pIC50	316	nM	IC50	Medchemcomm (2018) 9: 149-159 [PMID:30108908]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride substrate as substrate preincubated for 15 mins by Ellman's method	B	6.51	pIC50	311	nM	IC50	Eur J Med Chem (2011) 46: 5885-5893 [PMID:22019228]
ChEMBL	Inhibition of electric eel AChE after 15 mins by Ellman's method using acetylcholine as substrate	B	6.51	pIC50	311	nM	IC50	Bioorg Med Chem Lett (2010) 20: 6649-6652 [PMID:20880702]
ChEMBL	Inhibition of electric eel AChE using acetylcholine as substrate by Ellman's method	B	6.51	pIC50	311	nM	IC50	Bioorg Med Chem (2012) 20: 3038-3048 [PMID:22472046]
ChEMBL	Inhibition of Electrophorus electricus Acetylcholinesterase	B	6.52	pIC50	300	nM	IC50	J Med Chem (2007) 50: 5685-5695 [PMID:17944454]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2015) 89: 296-303 [PMID:25462245]
ChEMBL	Inhibition of electric eel AChE pre-incubated for 3 mins before acetylthiocholine substrate addition by Ellman's reagent based spectrophotometry	B	6.55	pIC50	280	nM	IC50	Eur J Med Chem (2015) 97: 181-189 [PMID:25969170]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180 seconds by Ellman's method	B	6.57	pIC50	269	nM	IC50	Eur J Med Chem (2013) 64: 540-553 [PMID:23685572]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method	B	6.57	pIC50	269	nM	IC50	Bioorg Med Chem Lett (2013) 23: 2636-2641 [PMID:23511019]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins by spectrophotometric method	B	6.59	pIC50	260	nM	IC50	Bioorg Med Chem (2014) 22: 6089-6104 [PMID:25282654]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition by Ellmans method	B	6.59	pIC50	260	nM	IC50	Eur J Med Chem (2013) 69: 632-646 [PMID:24095756]
ChEMBL	Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate after 10 mins by Ellman's spectrophotometric method	B	6.6	pIC50	250	nM	IC50	Bioorg Med Chem Lett (2011) 21: 4097-4103 [PMID:21641207]
ChEMBL	Inhibition of electric eel ACHE preincubated for 6 mins followed by addition of acetylcholine iodide as substrate by Ellman's method	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem (2016) 24: 4324-4338 [PMID:27460699]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 10 mins by Ellman's method	B	6.64	pIC50	230	nM	IC50	Medchemcomm (2018) 9: 1871-1881 [PMID:30568755]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (2019) 29: 839-843 [PMID:30686752]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by spectroscopy based Ellman's method	B	6.65	pIC50	226	nM	IC50	Eur J Med Chem (2017) 136: 36-51 [PMID:28478343]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 10 mins by spectrophotometry based Ellman's method	B	6.65	pIC50	223	nM	IC50	Eur J Med Chem (2019) 167: 161-186 [PMID:30771604]
ChEMBL	Inhibition of electric eel AChE	B	6.65	pIC50	223	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127609-127609 [PMID:33039562]
ChEMBL	inhibition of electric eel AChE by Ellman's method	B	6.65	pIC50	222.7	nM	IC50	Eur J Med Chem (2010) 45: 1415-1423 [PMID:20079560]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition measured for 1 min by Ellman's method	B	6.66	pIC50	221	nM	IC50	Eur J Med Chem (2016) 123: 298-308 [PMID:27484515]
ChEMBL	Inhibition of electric eel AChE by Ellman's assay	B	6.66	pIC50	220	nM	IC50	J Nat Prod (2006) 69: 1341-1346 [PMID:16989531]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's method	B	6.66	pIC50	219	nM	IC50	Bioorg Med Chem (2013) 21: 7275-7282 [PMID:24148835]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method	B	6.66	pIC50	218	nM	IC50	Eur J Med Chem (2016) 123: 282-297 [PMID:27484514]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate by spectrophotometer analysis	B	6.67	pIC50	215	nM	IC50	Bioorg Med Chem (2014) 22: 3213-3219 [PMID:24794747]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method	B	6.68	pIC50	207	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126927-126927 [PMID:31901382]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method	B	6.69	pIC50	205	nM	IC50	Medchemcomm (2014) 5: 609-616
ChEMBL	Inhibition of electric eel AChE using ATC as substrate preincubated for 15 mins followed by substrate addition by UV-spectrophotometric analysis	B	6.72	pIC50	192.6	nM	IC50	Eur J Med Chem (2016) 122: 17-26 [PMID:27343850]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	6.72	pIC50	192.6	nM	IC50	Bioorg Med Chem (2011) 19: 763-770 [PMID:21211982]
ChEMBL	Inhibition of electric eel AChE using acetylcholine as substrate preincubated for 15 mins followed by substrate addition by Ellman's method	B	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2016) 118: 178-192 [PMID:27128182]
ChEMBL	Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylcholine iodide as substrate by Ellman's assay	B	6.72	pIC50	190	nM	IC50	Medchemcomm (2015) 6: 1969-1977
ChEMBL	Inhibition of electric eel AChE using acetylcholine iodide as substrate preincubated for 15 mins prior to substrate addition by Ellman's method	B	6.72	pIC50	190	nM	IC50	Bioorg Med Chem (2013) 21: 4559-4569 [PMID:23768661]
ChEMBL	Inhibition of electric eel AChE preincubated for 30 mins prior to horseradish peroxidase, H2O2 and DETAPAC addition measured for 20 mins under ROS condition by Muraoka and Miura method	B	6.74	pIC50	183	nM	IC50	Bioorg Med Chem (2013) 21: 3614-3623 [PMID:23535563]
ChEMBL	Inhibition of electric eel AChE by Rappaport method	B	6.74	pIC50	180	nM	IC50	J Med Chem (2009) 52: 2724-2732 [PMID:19374444]
ChEMBL	Inhibition of Electrophorus electricus AChE	B	6.74	pIC50	180	nM	IC50	J Med Chem (2006) 49: 7607-7610 [PMID:17181144]
ChEMBL	Inhibition of Electrophorus electricus AChE by spectrophotometry	B	6.74	pIC50	180	nM	IC50	Bioorg Med Chem (2008) 16: 7759-7769 [PMID:18640842]
ChEMBL	Inhibition of electric eel AChE	B	6.76	pIC50	173	nM	IC50	Bioorg Med Chem Lett (2010) 20: 3606-3609 [PMID:20472431]
ChEMBL	Inhibition of Electrophorus electricus AChE by Ellman's method	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2007) 15: 6596-6607 [PMID:17681794]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every minute by Ellman's method	B	6.84	pIC50	143.5	nM	IC50	Eur J Med Chem (2018) 144: 128-136 [PMID:29268129]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins by Ellman's method	B	6.85	pIC50	142	nM	IC50	Bioorg Med Chem (2016) 24: 6031-6039 [PMID:27720328]
ChEMBL	Inhibition of electric eel AChE	B	6.85	pIC50	140	nM	IC50	Eur J Med Chem (2019) 166: 381-389 [PMID:30739821]
ChEMBL	Inhibition of electric eel AchE using acetylthiocholine iodide as substrate by Ellman method	B	6.87	pIC50	136	nM	IC50	Bioorg Med Chem Lett (2015) 25: 830-833 [PMID:25597004]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate by spectroscopic Ellmans method	B	6.87	pIC50	136	nM	IC50	Eur J Med Chem (2011) 46: 2193-2205 [PMID:21435752]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	6.89	pIC50	130	nM	IC50	J Med Chem (2009) 52: 2724-2732 [PMID:19374444]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins incubation by Ellman's method	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2257-2261 [PMID:22341944]
ChEMBL	Inhibition of electric eel AChE preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 2 mins by Ellman's method	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2016) 119: 260-277 [PMID:27227482]
ChEMBL	Inhibition of electric eel AchE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition and measured after 2 mins by Ellman's method	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2016) 24: 2777-2788 [PMID:27157006]
ChEMBL	Inhibition of electric eel AChE using ATC iodide substrate by Ellman's assay	B	6.9	pIC50	126.7	nM	IC50	Bioorg Med Chem (2015) 23: 5610-5618 [PMID:26242241]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method	B	6.95	pIC50	113	nM	IC50	J Med Chem (2013) 56: 9089-9099 [PMID:24160297]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's method	B	6.95	pIC50	112.1	nM	IC50	Eur J Med Chem (2015) 93: 42-50 [PMID:25656088]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman method	B	6.95	pIC50	111	nM	IC50	Bioorg Med Chem (2013) 21: 7406-7417 [PMID:24128814]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's method	B	6.96	pIC50	110.2	nM	IC50	Eur J Med Chem (2013) 62: 745-753 [PMID:23454517]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition measured up to 180 secs by spectrophotometric-based Ellman's method	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2016) 24: 1528-1539 [PMID:26917219]
ChEMBL	Inhibition of electric eel acetylcholinesterase using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem (2014) 22: 1355-1361 [PMID:24461494]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 5 mins by UV spectrophotometric analysis	B	6.96	pIC50	110	nM	IC50	Eur J Med Chem (2017) 139: 612-632 [PMID:28841514]
ChEMBL	Inhibition of electric eel AchE using acetylthiocholine as substrate by Ellman's method	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2019) 29: 2150-2152 [PMID:31281020]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method	B	6.96	pIC50	109	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6737-6742 [PMID:24220172]
ChEMBL	Inhibition of electric eel AChE preincubated for 15 mins by Ellman's method	B	6.96	pIC50	109	nM	IC50	Eur J Med Chem (2014) 87: 429-439 [PMID:25282266]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric analysis	B	6.96	pIC50	109	nM	IC50	Bioorg Med Chem (2017) 25: 2946-2955 [PMID:28454848]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method	B	6.96	pIC50	109	nM	IC50	Bioorg Med Chem (2012) 20: 5884-5892 [PMID:22944335]
ChEMBL	Inhibition of electric eel acetylcholinesterase using acetylthiocholine as substrate incubated for 15 mins followed by substrate addition measured for 2 mins by Ellman's method	B	6.97	pIC50	108	nM	IC50	Eur J Med Chem (2013) 63: 299-312 [PMID:23501115]
ChEMBL	Inhibition of electric eel AChE using ACTI as substrate preincubated for 29 mins followed by substrate addition measured at 1 min intervals for 10 mins by Ellman's assay	B	6.97	pIC50	107	nM	IC50	J Med Chem (2016) 59: 7683-7689 [PMID:27405689]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	6.98	pIC50	105	nM	IC50	Eur J Med Chem (2011) 46: 1572-1581 [PMID:21367493]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's method	B	6.98	pIC50	104	nM	IC50	Eur J Med Chem (2011) 46: 4970-4979 [PMID:21871694]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by Ellman's method	B	6.99	pIC50	102	nM	IC50	Eur J Med Chem (2017) 125: 853-864 [PMID:27744252]
ChEMBL	Inhibition of electric eel AChE pre-incubated for 20 mins before acetylcholine iodide substrate addition by Ellman's assay	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2015) 25: 807-810 [PMID:25597007]
ChEMBL	Inhibition of electric eel AchE	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2008) 18: 3790-3793 [PMID:18524585]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman method	B	7.01	pIC50	97.3	nM	IC50	Eur J Med Chem (2015) 95: 153-165 [PMID:25812965]
ChEMBL	Inhibition of electric eel acetylcholinesterase using acetylcholine chloride as substrate preincubated for 15 mins before substrate addition by Ellman's method	B	7.02	pIC50	96	nM	IC50	Bioorg Med Chem (2012) 20: 2527-2534 [PMID:22444876]
ChEMBL	Inhibition of electric eel AChE preincubated for 15 mins followed by addition of acetylthiocholine iodide as substrate measured after 30 mins by Ellman's microplate assay	B	7.02	pIC50	95	nM	IC50	Bioorg Med Chem (2016) 24: 3742-3751 [PMID:27328658]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition measured every 2 mins for 20 mins by Ellman's method	B	7.02	pIC50	94.69	nM	IC50	Eur J Med Chem (2017) 139: 367-377 [PMID:28810188]
ChEMBL	Inhibition of Electric eel AChE assessed as amount of thiocholine released using acetylthiocholine iodide as substrate after 6 mins by Ellman's method	B	7.05	pIC50	90	nM	IC50	J Nat Prod (2014) 77: 650-656 [PMID:24521095]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 10 mins by Ellman's method	B	7.05	pIC50	89.91	nM	IC50	Eur J Med Chem (2018) 145: 760-769 [PMID:29353726]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method	B	7.07	pIC50	86	nM	IC50	Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112]
ChEMBL	Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay	B	7.07	pIC50	85.8	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4462-4466 [PMID:22633691]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition by Ellman's method	B	7.12	pIC50	75	nM	IC50	Bioorg Med Chem (2013) 21: 4928-4937 [PMID:23891231]
ChEMBL	Inhibition of Electrophorus electricus AChE after 120 secs by Ellman spectroscopic method	B	7.13	pIC50	74	nM	IC50	Bioorg Med Chem (2010) 18: 7873-7877 [PMID:20943395]
ChEMBL	Inhibition of Electrophorus electricus AChE by Ellman's method	B	7.13	pIC50	74	nM	IC50	J Med Chem (2007) 50: 5311-5323 [PMID:17902635]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 20 mins followed by substrate addition by Ellman's method	B	7.13	pIC50	73.36	nM	IC50	Eur J Med Chem (2016) 116: 200-209 [PMID:27061983]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by DTNB addition for 5 mins and subsequent addition of substrate measured after 3 mins by Ellman's method	B	7.15	pIC50	70.7	nM	IC50	Eur J Med Chem (2018) 148: 238-254 [PMID:29466774]
ChEMBL	Inhibition of electric eel AchE using acetylthiocholine as substrate measured for 6 mins by Ellman's method	B	7.15	pIC50	70	nM	IC50	J Nat Prod (2020) 83: 852-863 [PMID:32150413]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 5 mins by Ellman's method	B	7.16	pIC50	69.8	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3162-3165 [PMID:23639542]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by Ellman's method	B	7.16	pIC50	69.8	nM	IC50	Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate challenge measured after 15 mins by Ellman's method	B	7.19	pIC50	65	nM	IC50	Bioorg Med Chem (2014) 22: 2496-2507 [PMID:24657052]
ChEMBL	Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 5 mins prior to substrate addition measured every 3 mins by Ellman's assay	B	7.19	pIC50	64.57	nM	IC50	J Med Chem (2012) 55: 3588-3592 [PMID:22420827]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride substrate incubated for 5 mins before substrate addition measured at 3 min interval by Ellman method	B	7.19	pIC50	64.57	nM	IC50	Bioorg Med Chem (2012) 20: 6513-6522 [PMID:23000296]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins followed by substrate addition by Ellman's method	B	7.21	pIC50	61	nM	IC50	Eur J Med Chem (2016) 122: 326-338 [PMID:27376495]
ChEMBL	Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholineiodide as substrate measured at 30 secs intervals over 9 mins by Ellman's colorimetric assay	B	7.24	pIC50	58	nM	IC50	Bioorg Med Chem Lett (2015) 25: 5609-5612 [PMID:26510670]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 10 mins prior to substrate addition measured every 30 seconds for 30 mins by Ellman's method	B	7.28	pIC50	52.4	nM	IC50	Bioorg Med Chem (2013) 21: 3614-3623 [PMID:23535563]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine preincubated for 10 mins followed by addition of substrate and measured every 30 secs for 20 mins	B	7.28	pIC50	52.4	nM	IC50	Medchemcomm (2019) 10: 2052-2072 [PMID:32206241]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine chloride as substrate peincubated for 15 mins followed by substrate addition measured at 1 min interval by Ellman's method	B	7.29	pIC50	51.3	nM	IC50	Bioorg Med Chem Lett (2020) 30: 126880-126880 [PMID:31864798]
ChEMBL	Inhibition of Electrophorus electricus C2888 AChE using acetylthiocholine iodide as substrate by Ellman's spectroscopic method	B	7.3	pIC50	50	nM	IC50	J Nat Prod (2012) 75: 2012-2015 [PMID:23134335]
ChEMBL	Compound was assessed for in vitro inhibition of Acetylcholinesterase isolated from Electrophorus electricus	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2000) 10: 637-639 [PMID:10762042]
ChEMBL	Inhibition of Electrophorus electricus AChE pre-incubated for 5 mins before acetylthiocholine iodide substrate addition by Ellman's method	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem Lett (2015) 25: 3442-3446 [PMID:26212777]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by Ellman's method	B	7.32	pIC50	48	nM	IC50	Eur J Med Chem (2017) 125: 1200-1212 [PMID:27863370]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	7.33	pIC50	46.5	nM	IC50	Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	7.33	pIC50	46.45	nM	IC50	Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	7.34	pIC50	45.71	nM	IC50	J Med Chem (2010) 53: 2094-2103 [PMID:20158205]
ChEMBL	Inhibition of electric eel AChE by colorimetric Ellman assay	B	7.34	pIC50	45.71	nM	IC50	J Med Chem (2012) 55: 5231-5242 [PMID:22624880]
ChEMBL	Inhibition of electric eel AchE by Ellman's assay	B	7.35	pIC50	45.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2905-2909 [PMID:18406135]
ChEMBL	Inhibition of Electric eel AChE	B	7.35	pIC50	45.1	nM	IC50	J Med Chem (2008) 51: 7666-7669 [PMID:19053746]
ChEMBL	Inhibition of electric eel AChE by modified Ellman's method	B	7.35	pIC50	45.08	nM	IC50	J Med Chem (2010) 53: 3611-3617 [PMID:20361801]
ChEMBL	Inhibition of electric eel AChE by modified Ellman's method	B	7.35	pIC50	45	nM	IC50	J Med Chem (2010) 53: 3611-3617 [PMID:20361801]
ChEMBL	Inhibition of Electrophorus electricus AChE pre-incubated for 10 mins before addition of acetylthiocholine iodide substrate and further incubated for 15 mins by Ellman's method	B	7.35	pIC50	44.3	nM	IC50	J Med Chem (2016) 59: 9967-9973 [PMID:27736061]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	7.37	pIC50	42.95	nM	IC50	Bioorg Med Chem (2010) 18: 1181-1193 [PMID:20061157]
ChEMBL	Inhibition of electric eel AchE using acetylcholine as substrate preincubated for 15 mins followed by substrate addition measured for 5 mins by Ellman method	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2014) 74: 491-501 [PMID:24502897]
ChEMBL	In vitro inhibition of electric eel acetylcholinesterase	B	7.41	pIC50	39	nM	IC50	J Med Chem (2001) 44: 2707-2718 [PMID:11495583]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by modified Ellman's method	B	7.42	pIC50	38	nM	IC50	Bioorg Med Chem (2016) 24: 2352-2359 [PMID:27083471]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 5 mins by Ellman's method	B	7.5	pIC50	31.8	nM	IC50	Eur J Med Chem (2020) 185: 111785-111785 [PMID:31669851]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition measured after 15 mins by spectrophotometry based Ellman method	B	7.52	pIC50	30	nM	IC50	Eur J Med Chem (2017) 126: 576-589 [PMID:27918993]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide substrate by Ellman assay	B	7.57	pIC50	27.2	nM	IC50	J Med Chem (2015) 58: 6710-6715 [PMID:26278660]
ChEMBL	Inhibition Assay: The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an electric eel as an AChE neuronal model (Electrophorus electricus) and acetylthiocholine iodide (0.35 mM) as substrate. The reaction took place in a final volume of 3 mL of a 0.1 M phosphate buffer solution, pH 8.0, containing 0.035 units of AChE and used a 0.35 mM solution of 5,5'-dithio-bis(2-nitrobenzoic acid) (DTNB) to produce the 5-thio-2-nitrobenzoic acid anion. Inhibition curves were performed in triplicate by incubating at least nine inhibitor concentrations for 10 min. A triplicate sample without inhibitor was always present so as to be aware of 100% of the AChE activity. After this time, the substrate was added to 0.35 mM acetylthiocholine iodide, from a 10 mM stock solution. Loss of color was observed at 412 nm in a spectrophotometric reader having 96 well plates.	B	7.57	pIC50	27	nM	IC50	US-8999994-B2. Derivatives of propargylamine having neuroprotective capacity for the treatment of Alzheimer's and Parkinson's diseases (2015)
ChEMBL	Inhibition of Electrophorus electricus acetylcholinesterase preincubated with compound for 10 mins using acetylcholine iodide as substrate after 15 mins by spectrophotometric analysis	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2384-2388 [PMID:21411323]
ChEMBL	Inhibition of electric eel AChE after 15 mins by Ellman's method	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2011) 46: 1-10 [PMID:21111515]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2012) 52: 251-262 [PMID:22503231]
ChEMBL	Inhibition of Electrophorus electricus AChE by Ellman's method	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem (2011) 19: 122-133 [PMID:21163662]
ChEMBL	Inhibition of electric eel AChE preincubated for 10 mins measured after 15 mins by Ellman's method	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2011) 46: 4676-4681 [PMID:21715067]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	7.57	pIC50	27	nM	IC50	J Med Chem (2010) 53: 5129-5143 [PMID:20575555]
ChEMBL	Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry	B	7.57	pIC50	27	nM	IC50	J Med Chem (2005) 48: 8270-8288 [PMID:16366609]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by Ellman's method	B	7.57	pIC50	27	nM	IC50	Eur J Med Chem (2011) 46: 6119-6130 [PMID:22000936]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate pretreated for 4.5 mins followed by substrate addition and measured after 2.5 mins by Ellman's method	B	7.6	pIC50	25.12	nM	IC50	Medchemcomm (2017) 8: 1346-1359 [PMID:30108847]
ChEMBL	Inhibition of electric eel AChE	B	7.62	pIC50	24.1	nM	IC50	Bioorg Med Chem (2014) 22: 4867-4881 [PMID:25047936]
ChEMBL	Inhibition of electric eel AChE	B	7.62	pIC50	24.04	nM	IC50	Bioorg Med Chem (2014) 22: 4867-4881 [PMID:25047936]
ChEMBL	Inhibition of Electrophorus electricus AChE after 5 mins by Ellman's method	B	7.62	pIC50	24	nM	IC50	Eur J Med Chem (2015) 92: 738-749 [PMID:25621991]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellmans method	B	7.62	pIC50	24	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4140-4145 [PMID:27445168]
ChEMBL	Inhibition of electric eel AChE preincubated for 5 mins followed by acetylthiocholine iodide substrate addition measured after 5 mins by Ellman's method	B	7.62	pIC50	24	nM	IC50	Eur J Med Chem (2016) 124: 63-81 [PMID:27560283]
ChEMBL	Inhibition of Electrophorus electricus AChE pre-incubated for 5 mins before addition of acetylthiocholine iodide substrate by Ellman's assay	B	7.62	pIC50	24	nM	IC50	Bioorg Med Chem (2015) 23: 1629-1637 [PMID:25707322]
ChEMBL	Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by Ellman's method	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2020) 187: 111916-111916 [PMID:31812794]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophotometric based Ellman's method	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2021) 225: 113783-113783 [PMID:34461507]
ChEMBL	Inhibition of Electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2017) 125: 676-695 [PMID:27721153]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by Ellman's method	B	7.64	pIC50	23	nM	IC50	Eur J Med Chem (2021) 218: 113397-113397 [PMID:33838585]
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 1 min in presence of H2O2 by Ellman's method	B	7.66	pIC50	21.63	nM	IC50	Eur J Med Chem (2021) 212: 112997-112997 [PMID:33189440]
ChEMBL	Inhibition of electric eel AChE by Ellman's method	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem Lett (2021) 49: 128316-128316 [PMID:34391893]
ChEMBL	Inhibition of electric eel AChE preincubated for 5 mins by Ellman's method	B	7.76	pIC50	17.38	nM	IC50	Eur J Med Chem (2010) 45: 5602-5611 [PMID:20926161]
ChEMBL	In vitro inhibitory activity against acetylcholinesterase (AChE) in Electrophorus electricus	B	7.8	pIC50	16	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2389-2391 [PMID:12824041]
ChEMBL	Inhibition of electric eel AChE by colorimetric Ellman assay	B	7.81	pIC50	15.6	nM	IC50	J Med Chem (2012) 55: 5231-5242 [PMID:22624880]
ChEMBL	Inhibition of acetylcholinesterase (AChE) in electric eel (type V-S) by modified radiometric assay	B	8.03	pIC50	9.33	nM	IC50	Bioorg Med Chem Lett (1992) 2: 861-864
ChEMBL	Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2016) 26: 1624-1628 [PMID:26869193]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex by Lineweaver-Burk plot	B	6.65	pKi	225	nM	Ki	J Med Chem (2014) 57: 7073-7084 [PMID:25089370]
ChEMBL	Inhibitory activity of compound against acetylcholinesterase from human erythrocytes	B	6.82	pKi	151	nM	Ki	J Med Chem (2003) 46: 954-966 [PMID:12620072]
ChEMBL	Competitive inhibition constant for Acetylcholinesterase	B	6.82	pKi	151	nM	Ki	J Med Chem (2005) 48: 24-27 [PMID:15633997]
ChEMBL	Inhibition of human AChE	B	6.86	pKi	137	nM	Ki	J Med Chem (2006) 49: 3421-3425 [PMID:16722663]
ChEMBL	Inhibition of human recombinant AChE assessed as dissociation constant for enzyme-inhibitor-substrate complex by Lineweaver-Burk plot	B	7	pKi	101	nM	Ki	J Med Chem (2014) 57: 7073-7084 [PMID:25089370]
ChEMBL	Inhibition of human recombinant AChE	B	7.44	pKi	36	nM	Ki	J Med Chem (2008) 51: 3154-3170 [PMID:18479118]
ChEMBL	Inhibition of human recombinant AChE	B	7.44	pKi	36	nM	Ki	Bioorg Med Chem Lett (2008) 18: 5213-5216 [PMID:18786825]
ChEMBL	Inhibition of human AChE assessed as acetylthiocholine hydrolysis	B	7.45	pKi	35.7	nM	Ki	Bioorg Med Chem (2014) 22: 4784-4791 [PMID:25088549]
ChEMBL	Inhibition of human recombinant AChE using acetylthiocholine as substrate	B	7.49	pKi	32.12	nM	Ki	Bioorg Med Chem (2012) 20: 6739-6750 [PMID:23041347]
GtoPdb	-	-	7.5	pKi	30	nM	Ki	J Med Chem (2008) 51: 3154-70 [PMID:18479118]
ChEMBL	Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Lineweaver-Burk plot analysis	B	8.12	pKi	7.64	nM	Ki	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibition of human recombinant AChE by Ellman's method	B	5.99	pIC50	1030	nM	IC50	J Med Chem (2007) 50: 5311-5323 [PMID:17902635]
ChEMBL	Inhibition of human Acetylcholinesterase	B	6.03	pIC50	926	nM	IC50	J Med Chem (2007) 50: 5685-5695 [PMID:17944454]
ChEMBL	Inhibition of human AChE by Ellmans test	B	6.1	pIC50	800	nM	IC50	J Med Chem (2010) 53: 6490-6505 [PMID:20684567]
ChEMBL	Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem (2017) 25: 3997-4007 [PMID:28578994]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition by Ellman's method	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem (2018) 26: 4716-4725 [PMID:30104121]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	B	6.22	pIC50	600	nM	IC50	Bioorg Med Chem (2017) 25: 5981-5994 [PMID:28986116]
ChEMBL	Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method	B	6.27	pIC50	534	nM	IC50	Bioorg Med Chem (2014) 22: 1355-1361 [PMID:24461494]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method	B	6.27	pIC50	534	nM	IC50	J Med Chem (2013) 56: 9089-9099 [PMID:24160297]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition by Ellman's method	B	6.28	pIC50	520	nM	IC50	Bioorg Med Chem (2013) 21: 4928-4937 [PMID:23891231]
ChEMBL	Inhibition of acetylcholinesterase in human erythrocytes using acetylthiocholine iodide substrate by spectrophotometric Ellman's method	B	6.3	pIC50	501	nM	IC50	Bioorg Med Chem (2015) 23: 5610-5618 [PMID:26242241]
ChEMBL	Inhibition of human recombinant AChE after 5 mins	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2010) 20: 6093-6095 [PMID:20817518]
ChEMBL	Inhibition of human recombinant AChE after 5 mins using spectrophotometer by Ellman's method	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6563-6566 [PMID:21920739]
ChEMBL	Inhibition of human recombinant AChE after 5 mins by Ellman method	B	6.3	pIC50	500	nM	IC50	J Med Chem (2014) 57: 8576-8589 [PMID:25259726]
ChEMBL	Inhibition of human recombinant AChE pre-incubated for 5 mins before acetylthiocholine substrate addition by Ellman's method	B	6.3	pIC50	500	nM	IC50	J Med Chem (2014) 57: 7073-7084 [PMID:25089370]
ChEMBL	Inhibition of human SH-SY5Y cell lysate acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by Ellman's method	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate by spectroscopic Ellmans method	B	6.32	pIC50	484	nM	IC50	Eur J Med Chem (2011) 46: 2193-2205 [PMID:21435752]
ChEMBL	Inhibition of human recombinant AchE using acetylthiocholine iodide as substrate by Ellman method	B	6.32	pIC50	484	nM	IC50	Bioorg Med Chem Lett (2015) 25: 830-833 [PMID:25597004]
ChEMBL	Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 30 mins by Ellman's coupled enzyme assay	B	6.32	pIC50	480	nM	IC50	Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 6 mins by spectrophotometric method	B	6.33	pIC50	467	nM	IC50	Bioorg Med Chem (2014) 22: 6089-6104 [PMID:25282654]
ChEMBL	Inhibition of human erythrocytes AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method	B	6.34	pIC50	459	nM	IC50	Eur J Med Chem (2016) 123: 282-297 [PMID:27484514]
ChEMBL	Inhibition of human erythrocyte ACHE preincubated for 6 mins followed by addition of acetylcholine iodide as substrate by Ellman's method	B	6.35	pIC50	450	nM	IC50	Bioorg Med Chem (2016) 24: 4324-4338 [PMID:27460699]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's method	B	6.36	pIC50	435.1	nM	IC50	Eur J Med Chem (2015) 93: 42-50 [PMID:25656088]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition measured up to 180 secs by Ellman's method	B	6.37	pIC50	430	nM	IC50	Eur J Med Chem (2018) 146: 287-298 [PMID:29407958]
ChEMBL	Inhibition of human recombinant AChE	B	6.37	pIC50	426.58	nM	IC50	J Med Chem (2004) 47: 6490-6498 [PMID:15588084]
ChEMBL	Inhibition of Acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate by Ellman's spectrophotometric method	B	6.37	pIC50	425.6	nM	IC50	Bioorg Med Chem (2019) 27: 3979-3997 [PMID:31401008]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method	B	6.37	pIC50	424	nM	IC50	J Med Chem (2016) 59: 114-131 [PMID:26632651]
ChEMBL	Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method	B	6.37	pIC50	424	nM	IC50	Eur J Med Chem (2014) 73: 141-152 [PMID:24389509]
ChEMBL	Inhibition of human recombinant AChE using ATCh as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by Ellman method	B	6.37	pIC50	424	nM	IC50	Eur J Med Chem (2019) 168: 58-77 [PMID:30798053]
ChEMBL	Inhibition of Acetylcholinesterase	B	6.37	pIC50	424	nM	IC50	J Med Chem (2005) 48: 24-27 [PMID:15633997]
ChEMBL	Inhibitory concentration against human recombinant acetylcholinesterase	B	6.37	pIC50	424	nM	IC50	J Med Chem (2005) 48: 360-363 [PMID:15658850]
ChEMBL	Inhibition of human serum AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 3 mins by Ellman's method	B	6.37	pIC50	424	nM	IC50	Eur J Med Chem (2017) 141: 197-210 [PMID:29031067]
ChEMBL	Inhibition of human recombinant acetylcholinesterase	B	6.37	pIC50	424	nM	IC50	J Med Chem (2007) 50: 4882-4897 [PMID:17850125]
ChEMBL	Inhibition of human serum recombinant AChE by Ellman's method	B	6.37	pIC50	424	nM	IC50	J Med Chem (2007) 50: 6446-6449 [PMID:18047264]
ChEMBL	Inhibition of human recombinant AChE by Ellman's method	B	6.37	pIC50	424	nM	IC50	J Med Chem (2008) 51: 4381-4384 [PMID:18605718]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman method	B	6.38	pIC50	420.32	nM	IC50	Eur J Med Chem (2015) 95: 153-165 [PMID:25812965]
ChEMBL	Inhibition of human AchE	B	6.38	pIC50	420	nM	IC50	J Med Chem (2008) 51: 347-372 [PMID:18181565]
ChEMBL	Inhibition of AChE in human erythrocyte hemo-lyzates pre-incubated for 5 mins before addition of acetylthiocholine iodide substrate by Ellman's method	B	6.38	pIC50	420	nM	IC50	J Med Chem (2016) 59: 9967-9973 [PMID:27736061]
ChEMBL	Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate by Ellman's method	B	6.38	pIC50	420	nM	IC50	Eur J Med Chem (2012) 52: 251-262 [PMID:22503231]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate pre-incubated for 20 mins before substrate addition and measured for 180 secs by spectrophotometry based Ellman's method	B	6.39	pIC50	412	nM	IC50	Eur J Med Chem (2019) 167: 161-186 [PMID:30771604]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured at 1 min time interval by Ellman's method relative to control	B	6.4	pIC50	400	nM	IC50	Eur J Med Chem (2019) 167: 133-145 [PMID:30771601]
ChEMBL	Inhibition of human recombinant AChE by Ellman's assay	B	6.42	pIC50	383	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6254-6258 [PMID:24140444]
ChEMBL	Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine as substrate pretreated for 20 mins followed by substrate addition by Ellman's method	B	6.43	pIC50	374	nM	IC50	Eur J Med Chem (2018) 155: 839-846 [PMID:29958119]
ChEMBL	Inhibition of human AChE in erythrocyte	B	6.46	pIC50	350	nM	IC50	J Med Chem (2009) 52: 7249-7257 [PMID:19856923]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 10 mins prior to substrate addition measured after 15 mins by Ellman's method	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2012) 54: 750-763 [PMID:22795665]
ChEMBL	Inhibition of human AChE	B	6.46	pIC50	350	nM	IC50	J Med Chem (2006) 49: 459-462 [PMID:16420031]
ChEMBL	Inhibition of human erythrocytes AChE by Ellman's method	B	6.46	pIC50	350	nM	IC50	J Med Chem (2012) 55: 1303-1317 [PMID:22243648]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured for 5 mins by Ellman's assay	B	6.46	pIC50	350	nM	IC50	Medchemcomm (2017) 8: 1307-1317 [PMID:30108842]
ChEMBL	Inhibition of human erythrocyte AChE by Ellman's reaction	B	6.46	pIC50	350	nM	IC50	J Med Chem (2010) 53: 4927-4937 [PMID:20545360]
ChEMBL	DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine)	B	6.48	pIC50	330	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine as substrate assessed as substrate hydrolysis preincubated for 20 mins followed by substrate addition measured after 30 mins by Ellman's assay	B	6.48	pIC50	330	nM	IC50	J Nat Prod (2015) 78: 3075-3079 [PMID:26583263]
ChEMBL	Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method	B	6.49	pIC50	320	nM	IC50	Eur J Med Chem (2019) 168: 491-514 [PMID:30851693]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 2 mins time interval by Ellman's method	B	6.49	pIC50	320	nM	IC50	Eur J Med Chem (2018) 150: 292-306 [PMID:29533874]
ChEMBL	Inhibition of human recombinant AChE using acetylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 mins by Ellman's method	B	6.49	pIC50	320	nM	IC50	J Med Chem (2015) 58: 8985-9003 [PMID:26503905]
ChEMBL	Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method	B	6.49	pIC50	320	nM	IC50	J Med Chem (2020) 63: 9360-9390 [PMID:32706255]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine as substrate by DTNB-reagent based Ellman's method	B	6.49	pIC50	320	nM	IC50	Bioorg Med Chem Lett (2021) 43: 128100-128100 [PMID:33984470]
ChEMBL	Inhibition of human recombinant AChE assessed as reduction in cholinesterase activity using acetylthiocholine iodide as substrate by Ellman's method	B	6.49	pIC50	320	nM	IC50	Eur J Med Chem (2021) 219: 113434-113434 [PMID:33892271]
ChEMBL	Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins by spectrophotometry	B	6.5	pIC50	317	nM	IC50	J Med Chem (2012) 55: 661-669 [PMID:22185619]
ChEMBL	Inhibition of AChE (unknown origin)	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2014) 22: 3806-3814 [PMID:24934993]
ChEMBL	Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins prior to substrate addition by Ellman's method	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem Lett (2015) 25: 2804-2808 [PMID:26003339]
ChEMBL	Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 secs for 1 hr by Ellman's assay	B	6.52	pIC50	300	nM	IC50	Bioorg Med Chem (2019) 27: 442-446 [PMID:30579802]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method	B	6.52	pIC50	300	nM	IC50	Eur J Med Chem (2017) 130: 139-153 [PMID:28242549]
ChEMBL	Inhibition of human erythrocyte AChE preincubated for 15 mins by Ellman's method	B	6.55	pIC50	285	nM	IC50	Eur J Med Chem (2014) 87: 429-439 [PMID:25282266]
ChEMBL	Inhibition of human AChE using acetylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method	B	6.55	pIC50	285	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6737-6742 [PMID:24220172]
ChEMBL	Inhibition of human erythrocytic AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman method	B	6.55	pIC50	285	nM	IC50	Bioorg Med Chem (2013) 21: 7406-7417 [PMID:24128814]
ChEMBL	Compound was evaluated for the in vitro inhibition of the Acetylcholinesterase (AChE) from human erythrocytes,	B	6.57	pIC50	270	nM	IC50	J Med Chem (1994) 37: 2721-2734 [PMID:8064800]
ChEMBL	Inhibition of human erythrocyte AChE using S-acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured every 30 secs for 1 hr by Ellman's method	B	6.57	pIC50	270	nM	IC50	J Nat Prod (2017) 80: 1493-1504 [PMID:28445039]
ChEMBL	Inhibition against Acetylcholinesterase (AChE)	B	6.57	pIC50	269.77	nM	IC50	J Med Chem (1996) 39: 380-387 [PMID:8558505]
ChEMBL	Inhibition of human AchE using acetylthiocholine iodide as substrate incubated for 20 mins prior to substrate addition measured for 1 hr by Ellman's method	B	6.57	pIC50	268	nM	IC50	Bioorg Med Chem (2013) 21: 4218-4224 [PMID:23719283]
ChEMBL	Inhibitory concentration against human acetylcholinesterase	B	6.57	pIC50	267	nM	IC50	J Med Chem (2005) 48: 3564-3575 [PMID:15887964]
ChEMBL	Concentration required to inhibit 50% of Acetylcholinesterase obtained from human erythrocytes was determined in vitro	B	6.57	pIC50	267	nM	IC50	J Med Chem (1995) 38: 1084-1089 [PMID:7707311]
ChEMBL	Compound was tested in vitro for inhibitory activity against Acetylcholinesterase	B	6.6	pIC50	254	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2599-2602
ChEMBL	Inhibition of human recombinant AChE expressed in HEK293 cells by photometry	B	6.6	pIC50	251.19	nM	IC50	J Med Chem (2010) 53: 1338-1346 [PMID:20047331]
ChEMBL	Inhibitory concentration against acetylcholinesterase from human erythrocytes	B	6.6	pIC50	251.19	nM	IC50	J Med Chem (2003) 46: 954-966 [PMID:12620072]
ChEMBL	Inhibitory activity against human erythrocyte acetylcholinesterase	B	6.6	pIC50	251.19	nM	IC50	J Med Chem (2004) 47: 4471-4482 [PMID:15317459]
ChEMBL	Inhibition of human serum recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's method	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2011) 46: 4336-4343 [PMID:21798635]
ChEMBL	Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229]
ChEMBL	Inhibitory activity against human erythrocyte acetylcholinesterase	B	6.6	pIC50	250	nM	IC50	J Med Chem (2000) 43: 2007-2018 [PMID:10821713]
ChEMBL	Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins by Ellman's method	B	6.6	pIC50	250	nM	IC50	Eur J Med Chem (2014) 78: 157-166 [PMID:24681980]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured over 5 mins by UV-Vis spectrophotometric analysis	B	6.64	pIC50	230	nM	IC50	Eur J Med Chem (2017) 139: 773-791 [PMID:28863358]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition measured after 2 mins by Ellman's method	B	6.64	pIC50	230	nM	IC50	ACS Med Chem Lett (2018) 9: 171-176 [PMID:29541355]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method	B	6.64	pIC50	230	nM	IC50	Eur J Med Chem (2018) 158: 781-800 [PMID:30245401]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method	B	6.64	pIC50	230	nM	IC50	J Med Chem (2021) 64: 4972-4990 [PMID:33829779]
ChEMBL	Inhibition of human recombinant AchE using acetylthiocholine iodide as substrate incubated for 5 mins prior to substrate addition measured after 5 mins by Ellman method	B	6.64	pIC50	230	nM	IC50	J Med Chem (2014) 57: 3773-3785 [PMID:24738476]
ChEMBL	Inhibition of AChE	B	6.65	pIC50	223	nM	IC50	Eur J Med Chem (2010) 45: 1167-1172 [PMID:20053484]
ChEMBL	Inhibition of acetylcholinesterase (AChE) of human erythrocytes	B	6.66	pIC50	218.78	nM	IC50	J Med Chem (1998) 41: 4186-4189 [PMID:9784091]
ChEMBL	Inhibition of acetylcholinesterase isolated from Human erythrocytes.	B	6.69	pIC50	205	nM	IC50	J Med Chem (2000) 43: 4657-4666 [PMID:11101357]
ChEMBL	Inhibition of human erythrocyte AChE	B	6.69	pIC50	205	nM	IC50	J Med Chem (2006) 49: 6833-6840 [PMID:17154513]
ChEMBL	Inhibition of AChE by Ellman method	B	6.7	pIC50	200	nM	IC50	J Nat Prod (2007) 70: 1458-1461 [PMID:17822295]
ChEMBL	Inhibition of human AChE by Ellman's assay	B	6.7	pIC50	200	nM	IC50	J Nat Prod (2009) 72: 1151-1154 [PMID:19422203]
ChEMBL	Inhibition of AChE-induced amyloid beta aggregation	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144]
ChEMBL	Inhibitory concentration against acetylcholinesterase	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2005) 15: 2711-2715 [PMID:15878275]
ChEMBL	Inhibition of human erythrocyte AChE	B	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2014) 78: 455-467 [PMID:24704618]
ChEMBL	Inhibition of AChE (unknown origin)	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (2015) 25: 4848-4853 [PMID:26159481]
ChEMBL	Inhibitory concentration against human erythrocyte Acetylcholinesterase	B	6.72	pIC50	190	nM	IC50	J Med Chem (2005) 48: 986-994 [PMID:15715468]
ChEMBL	Inhibition of AChE (unknown origin)	B	6.72	pIC50	190	nM	IC50	J Med Chem (2014) 57: 8167-8179 [PMID:25226236]
ChEMBL	Inhibition of human recombinant AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate incubated for 10 mins by Ellman's method	B	6.72	pIC50	190	nM	IC50	Bioorg Med Chem (2021) 30: 115940-115940 [PMID:33340937]
ChEMBL	Inhibition of human plasma AChE	B	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491]
ChEMBL	Inhibition of human erythrocytes AChE	B	6.72	pIC50	190	nM	IC50	Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491]
ChEMBL	Ex vivo inhibition of human erythrocyte Acetylcholinesterase.	B	6.72	pIC50	190	nM	IC50	J Med Chem (2002) 45: 3684-3691 [PMID:12166941]
ChEMBL	Anticholinesterase activity against human erythrocyte AChE	B	6.72	pIC50	190	nM	IC50	J Med Chem (2006) 49: 2174-2185 [PMID:16570913]
ChEMBL	Inhibitory concentration required against acetylcholinesterase activity	B	6.74	pIC50	180	nM	IC50	J Med Chem (2001) 44: 4011-4014 [PMID:11689088]
ChEMBL	Inhibition of human acetylcholinesterase-I	B	6.74	pIC50	180	nM	IC50	J Med Chem (1992) 35: 1102-1108 [PMID:1552502]
ChEMBL	In vitro acetyl cholinesterase (AChE-I) inhibitory activity, ability to reverse the cholinergic deficit characteristic of AD	B	6.74	pIC50	180	nM	IC50	J Med Chem (1992) 35: 3141-3147 [PMID:1507203]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 1 min followed by substrate addition and measured after 10 mins by Ellman's method	B	6.76	pIC50	171.9	nM	IC50	Eur J Med Chem (2020) 207: 112751-112751 [PMID:32950908]
ChEMBL	In vitro inhibition of Acetylcholinesterase from human erythrocytes	B	6.77	pIC50	170	nM	IC50	J Med Chem (1995) 38: 2802-2808 [PMID:7636841]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method	B	6.8	pIC50	160	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 60 to 300 sec by Ellman's method	B	6.8	pIC50	160	nM	IC50	Medchemcomm (2015) 6: 1930-1941
ChEMBL	Inhibition of human AChE	B	6.8	pIC50	158.49	nM	IC50	J Med Chem (2019) 62: 9078-9102 [PMID:31609608]
ChEMBL	Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition measured after 10 mins by Ellman's method	B	6.82	pIC50	150	nM	IC50	Medchemcomm (2012) 3: 213-218
ChEMBL	Inhibition of human erythrocyte AChE by Ellman's method	B	6.82	pIC50	150	nM	IC50	Bioorg Med Chem (2008) 16: 7759-7769 [PMID:18640842]
ChEMBL	Inhibition of human erythrocyte AChE	B	6.83	pIC50	147	nM	IC50	J Med Chem (2006) 49: 7607-7610 [PMID:17181144]
ChEMBL	Inhibition of human serum AChE by Ellman's method	B	6.83	pIC50	147	nM	IC50	J Med Chem (2009) 52: 2724-2732 [PMID:19374444]
ChEMBL	In vitro inhibition of acetylcholinesterase isolated from human erythrocytes.	B	6.84	pIC50	143	nM	IC50	Bioorg Med Chem Lett (1991) 1: 411-414
ChEMBL	Inhibition of AChE (unknown origin) after 10 min by Ellmans method	B	6.85	pIC50	140	nM	IC50	Med Chem Res (2012) 21: 1785-1795
ChEMBL	Inhibition of human recombinant AChE pre-incubated for 5 mins before addition of acetylthiocholine iodide substrate by Ellman's assay	B	6.88	pIC50	131	nM	IC50	Bioorg Med Chem (2015) 23: 1629-1637 [PMID:25707322]
ChEMBL	Inhibition of human recombinant AChE preincubated for 5 mins followed by acetylthiocholine iodide substrate addition measured after 5 mins by Ellman's method	B	6.88	pIC50	131	nM	IC50	Eur J Med Chem (2016) 124: 63-81 [PMID:27560283]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 5 mins by Ellman's method	B	6.88	pIC50	131	nM	IC50	Eur J Med Chem (2020) 185: 111785-111785 [PMID:31669851]
ChEMBL	Inhibition of human recombinant AChE after 5 mins by Ellman's method	B	6.88	pIC50	131	nM	IC50	Eur J Med Chem (2015) 92: 738-749 [PMID:25621991]
ChEMBL	Inhibition of recombinant human AChE using ATCI as substrate incubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophotometric based Ellman's method	B	6.88	pIC50	131	nM	IC50	Eur J Med Chem (2020) 207: 112743-112743 [PMID:32882609]
ChEMBL	Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition measured after 5 mins by spectrophotometry based Ellman method	B	6.89	pIC50	130	nM	IC50	Eur J Med Chem (2017) 126: 576-589 [PMID:27918993]
ChEMBL	Inhibition of human AChE by Ellman's method	B	6.89	pIC50	128	nM	IC50	Bioorg Med Chem (2009) 17: 6937-6941 [PMID:19726199]
ChEMBL	Inhibition of cerebral human recombinant AchE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method	B	6.91	pIC50	122	nM	IC50	J Med Chem (2011) 54: 8251-8270 [PMID:22023459]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by DTNB addition for 5 mins and subsequent addition of substrate measured after 3 mins by Ellman's method	B	6.93	pIC50	116.8	nM	IC50	Eur J Med Chem (2018) 148: 238-254 [PMID:29466774]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's method	B	6.95	pIC50	111	nM	IC50	J Med Chem (2021) 64: 9302-9320 [PMID:34152756]
ChEMBL	Inhibition of human recombinant AChE after 20 mins using acetylthiocholine iodide as a substrate by Ellman's assay	B	6.96	pIC50	110	nM	IC50	J Med Chem (2011) 54: 2627-2645 [PMID:21417225]
ChEMBL	Inhibition of human AChE using acetylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's method	B	6.96	pIC50	109.65	nM	IC50	J Med Chem (2021) 64: 9302-9320 [PMID:34152756]
ChEMBL	Inhibition of acetylcholinesterase (unknown origin)	B	7	pIC50	100	nM	IC50	Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476]
ChEMBL	Inhibition of AChE in human erythrocytes by Ellman's method	B	7	pIC50	100	nM	IC50	J Med Chem (2010) 53: 5129-5143 [PMID:20575555]
ChEMBL	Inhibitory concentration against acetylcholinesterase (AChE) from human erythrocytes	B	7.02	pIC50	95	nM	IC50	J Med Chem (1999) 42: 730-741 [PMID:10052979]
ChEMBL	In vitro inhibition of acetylcholinesterase from human erythrocytes	B	7.02	pIC50	95	nM	IC50	J Med Chem (2001) 44: 2707-2718 [PMID:11495583]
ChEMBL	Inhibitory concentration against Acetylcholinesterase activity	B	7.05	pIC50	90	nM	IC50	Bioorg Med Chem Lett (2005) 15: 353-356 [PMID:15603953]
ChEMBL	Inhibition of human recombinant AChE	B	7.08	pIC50	84	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127609-127609 [PMID:33039562]
ChEMBL	Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	B	7.1	pIC50	79	nM	IC50	Bioorg Med Chem (2016) 24: 1050-1062 [PMID:26827140]
ChEMBL	Inhibition of AChE (unknown origin) by Ellman's method	B	7.1	pIC50	79	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126754-126754 [PMID:31708262]
ChEMBL	Inhibition of Acetylcholinesterase in human red blood cell	B	7.11	pIC50	78	nM	IC50	J Med Chem (1996) 39: 3014-3018 [PMID:8709135]
ChEMBL	Inhibition of human AChE by Ellman's assay	B	7.11	pIC50	77	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5881-5887 [PMID:21873056]
ChEMBL	Inhibition of human AChE pre-incubated for 6 mins before ATCI substrate addition and measured after 12 mins by DTNB reagent dependent UV-Vis spectrophotometry based Ellman's method	B	7.12	pIC50	76.5	nM	IC50	Eur J Med Chem (2017) 140: 118-127 [PMID:28923380]
ChEMBL	Inhibition acetylcholinesterase (AChE) enzyme.	B	7.12	pIC50	76.03	nM	IC50	J Med Chem (1997) 40: 4360-4371 [PMID:9435905]
ChEMBL	Inhibitory activity against Acetylcholinesterase	B	7.12	pIC50	76	nM	IC50	J Med Chem (1996) 39: 5064-5071 [PMID:8978837]
ChEMBL	Inhibition of Acetylcholinesterase in monkey red blood cell	B	7.12	pIC50	75	nM	IC50	J Med Chem (1996) 39: 3014-3018 [PMID:8709135]
ChEMBL	Inhibition of human erythrocytes AChE by Ellman's method	B	7.14	pIC50	72.38	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127659-127659 [PMID:33137375]
ChEMBL	Inhibition of human AChE	B	7.15	pIC50	71.61	nM	IC50	Bioorg Med Chem (2014) 22: 4867-4881 [PMID:25047936]
ChEMBL	Inhibition of human AChE	B	7.15	pIC50	71.5	nM	IC50	Bioorg Med Chem (2014) 22: 4867-4881 [PMID:25047936]
ChEMBL	Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by Ellman's method	B	7.26	pIC50	55	nM	IC50	Eur J Med Chem (2019) 182: 111651-111651 [PMID:31479975]
ChEMBL	In vitro inhibitory activity against acetylcholinesterase	B	7.28	pIC50	52	nM	IC50	J Med Chem (1992) 35: 584-589 [PMID:1738151]
ChEMBL	Inhibition of human erythrocyte AChE using ATCI as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by Ellman assay	B	7.3	pIC50	50	nM	IC50	J Med Chem (2016) 59: 5823-5846 [PMID:27253679]
ChEMBL	Inhibition of human erythrocytes BChE	B	7.33	pIC50	47	nM	IC50	Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491]
ChEMBL	Inhibition of human plasma BChE	B	7.33	pIC50	47	nM	IC50	Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491]
ChEMBL	Inhibition of AChE by Ellman's assay	B	7.35	pIC50	45.1	nM	IC50	J Med Chem (2008) 51: 713-716 [PMID:18232655]
ChEMBL	In vitro inhibitory activity against human erythrocyte acetylcholinesterase	B	7.47	pIC50	33.88	nM	IC50	J Med Chem (2004) 47: 4471-4482 [PMID:15317459]
ChEMBL	Inhibition of acetylcholinesterase (AChE) of human red blood cell (type XIII) by modified radiometric AChE assay	B	7.47	pIC50	33.5	nM	IC50	Bioorg Med Chem Lett (1992) 2: 861-864
ChEMBL	Inhibitory activity against acetylcholinesterase in human RBC	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (1996) 6: 737-742
ChEMBL	Inhibition of human acetylcholinesterase	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL	Inhibition of human erythrocyte AChE using ATC iodide as substrate preincubated for 4.5 mins followed by substrate addition measured after 2.5 mins by Ellman's method	B	7.7	pIC50	19.95	nM	IC50	J Med Chem (2018) 61: 1646-1663 [PMID:29400965]
ChEMBL	Inhibition of human erythrocyte AChE using ATC iodide as substrate preincubated for 4.5 mins followed by substrate addition measured after 2.5 mins by Ellman's method	B	7.73	pIC50	18.5	nM	IC50	J Med Chem (2018) 61: 1646-1663 [PMID:29400965]
ChEMBL	Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by spectrophotometry based Ellman's method	B	7.9	pIC50	12.59	nM	IC50	J Med Chem (2019) 62: 9078-9102 [PMID:31609608]
ChEMBL	Inhibition of AChE (unknown origin) using acetylcholine iodate as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	B	8.12	pIC50	7.53	nM	IC50	Bioorg Med Chem (2016) 24: 2318-2329 [PMID:27068142]
ChEMBL	Inhibition of AChE by Ellman's method	B	8.5	pIC50	3.16	nM	IC50	Eur J Med Chem (2011) 46: 3250-3257 [PMID:21570751]
Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795]
ChEMBL	Inhibition of fetal Bovine serum AChE	B	7.4	pKi	40	nM	Ki	J Med Chem (2003) 46: 1-4 [PMID:12502352]
ChEMBL	Inhibition of acetylcholinesterase (AChE) of fetal bovine serum (FBS)	B	7.4	pKi	40	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1779-1782 [PMID:11425559]
ChEMBL	Dissociation constant for inhibition of fetal bovine serum Acetylcholinesterase	B	7.4	pKi	40	nM	Ki	J Med Chem (2005) 48: 1919-1929 [PMID:15771436]
ChEMBL	Inhibition of bovine AChE by Elman's method	B	6.15	pIC50	710	nM	IC50	Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490]
ChEMBL	Inhibition of bovine erythrocyte acetylcholinesterase (AChE)	B	6.26	pIC50	550	nM	IC50	Bioorg Med Chem Lett (1996) 6: 77-80
ChEMBL	Inhibition of bovine erythrocytes AChE by Ellman's method	B	6.35	pIC50	446	nM	IC50	J Med Chem (2007) 50: 5311-5323 [PMID:17902635]
ChEMBL	Inhibition of bovine AChE	B	6.35	pIC50	445	nM	IC50	J Med Chem (2008) 51: 3154-3170 [PMID:18479118]
ChEMBL	Inhibition of bovine erythrocytes AChE using acetylthiocholine iodide as substrate by Ellman's methods	B	6.74	pIC50	180	nM	IC50	Eur J Med Chem (2019) 166: 381-389 [PMID:30739821]
ChEMBL	Inhibition of bovine erythrocyte AChE by Ellman's assay	B	6.78	pIC50	167	nM	IC50	J Med Chem (2008) 51: 3588-3598 [PMID:18517184]
ChEMBL	Inhibition of AchE in bovine erythrocytes	B	6.78	pIC50	167	nM	IC50	J Med Chem (2005) 48: 7223-7233 [PMID:16279781]
ChEMBL	Inhibition of bovine AChE by Ellman's method	B	6.87	pIC50	134	nM	IC50	Bioorg Med Chem (2008) 16: 7450-7456 [PMID:18585045]
ChEMBL	Inhibition of acetylcholinesterase (AChE)activity in bovine erythrocytes	B	6.89	pIC50	130	nM	IC50	J Med Chem (1999) 42: 3227-3242 [PMID:10464010]
ChEMBL	Inhibition of bovine erythrocyte AChE	B	6.89	pIC50	130	nM	IC50	J Med Chem (2006) 49: 6833-6840 [PMID:17154513]
ChEMBL	Compound was evaluated for the inhibition of acetylcholinesterase of bovine erythrocytes	B	6.89	pIC50	130	nM	IC50	J Med Chem (2000) 43: 4657-4666 [PMID:11101357]
ChEMBL	Inhibition of bovine erythrocytes AChE by Ellman's method	B	6.96	pIC50	109	nM	IC50	Bioorg Med Chem (2011) 19: 122-133 [PMID:21163662]
ChEMBL	Inhibition of bovine erythrocyte AChE by Ellman's reaction	B	7.4	pIC50	40	nM	IC50	J Med Chem (2010) 53: 4927-4937 [PMID:20545360]
ChEMBL	Inhibition of bovine erythrocyte AChE by Ellman's method	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2010) 45: 6152-6158 [PMID:20926162]
ChEMBL	Inhibition of AchE from bovine erythrocytes	B	7.4	pIC50	40	nM	IC50	J Med Chem (2006) 49: 459-462 [PMID:16420031]
ChEMBL	Inhibition of AChE in bovine erythrocyte by Ellman method	B	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 7249-7257 [PMID:19856923]
ChEMBL	Inhibition of AChE in bovine erythrocytes using acetylthiocholine as substrate by Ellman method	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2011) 46: 2224-2235 [PMID:21420206]
ChEMBL	Inhibition of bovine erythrocytes AChE by Ellman's method	B	7.4	pIC50	40	nM	IC50	J Med Chem (2012) 55: 1303-1317 [PMID:22243648]
ChEMBL	Displacement of propidium iodide from AChE in bovine erythrocytes after 15 mins by fluorescence plate reader	B	7.57	pIC50	27	nM	IC50	J Med Chem (2010) 53: 5129-5143 [PMID:20575555]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836]
ChEMBL	Dissociation constant towards Acetylcholinesterase in mouse	B	7.74	pKd	18	nM	Kd	J Med Chem (2004) 47: 3463-3482 [PMID:15214773]
ChEMBL	Inhibition of mouse AChE using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's method	B	6.7	pIC50	200	nM	IC50	J Med Chem (2021) 64: 7483-7506 [PMID:34024109]
ChEMBL	Inhibition of Acetylcholinesterase in mouse red blood cell	B	6.84	pIC50	143	nM	IC50	J Med Chem (1996) 39: 3014-3018 [PMID:8709135]
ChEMBL	Inhibition of Swiss albino mouse RBC AChE after 30 mins by Ellman method	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2012) 20: 6313-6320 [PMID:23026084]
ChEMBL	Inhibition of recombinant mouse AChE by Ellman method	B	6.97	pIC50	106	nM	IC50	J Med Chem (2014) 57: 8167-8179 [PMID:25226236]
ChEMBL	Inhibition of mouse recombinant AChE using butyrylthiocholine iodide as substrate after 5 mins by Ellman's method	B	6.97	pIC50	106	nM	IC50	Bioorg Med Chem (2015) 23: 4442-4452 [PMID:26116179]
ChEMBL	In vitro inhibitory concentration against acetylcholinesterase (AChE) obtained from mouse brain homogenate.	B	7.09	pIC50	81	nM	IC50	J Med Chem (1992) 35: 4542-4548 [PMID:1469686]
ChEMBL	Inhibitory activity against acetylcholinesterase	B	7.1	pIC50	80.3	nM	IC50	J Med Chem (1995) 38: 4821-4829 [PMID:7490731]
ChEMBL	Inhibition of AChE in Swiss Webster mouse cerebral homogenate using acetylthiocholine iodide as substrate preincubated for 10 mins followed substrate addition measured after 10 mins by Ellman's method	B	7.46	pIC50	34.3	nM	IC50	Bioorg Med Chem (2018) 26: 5566-5577 [PMID:30340901]
ChEMBL	Inhibition of AChE in Swiss mouse brain using acetylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition and measured after 10 mins	B	7.52	pIC50	30	nM	IC50	Medchemcomm (2019) 10: 2089-2101 [PMID:32904099]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136]
ChEMBL	Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine	B	6.22	pIC50	600	nM	IC50	J Med Chem (2020) 63: 11420-11435 [PMID:32539387]
ChEMBL	Inhibitory concentration against Acetylcholinesterase in rat brain	B	6.23	pIC50	590	nM	IC50	J Med Chem (2004) 47: 3463-3482 [PMID:15214773]
ChEMBL	Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric method	B	6.23	pIC50	590	nM	IC50	Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL	Concentration that causes 50% inhibition of Acetylcholinesterase (AChE) using rat cortex homogenate and ethopropazine	B	6.48	pIC50	333	nM	IC50	J Med Chem (2002) 45: 2277-2282 [PMID:12014965]
ChEMBL	Inhibitory activity against acetylcholinesterase in rat striatal preparation	B	6.49	pIC50	320	nM	IC50	J Med Chem (1996) 39: 570-581 [PMID:8558529]
ChEMBL	In vitro inhibition against acetylcholinesterase in rat striata.	B	6.5	pIC50	319	nM	IC50	J Med Chem (1989) 32: 1805-1813 [PMID:2754707]
ChEMBL	In vitro inhibitory activity against acetylcholinesterase using rat striatal preparations	B	6.51	pIC50	310	nM	IC50	J Med Chem (1988) 31: 1278-1279 [PMID:3385720]
ChEMBL	Inhibition of acetylcholinesterase (AChE)	B	6.57	pIC50	270.9	nM	IC50	J Med Chem (1994) 37: 2292-2299 [PMID:8057278]
ChEMBL	Inhibition of AChE in Sprague-Dawley rat cortices using acetylthiocholine iodide as substrate by Ellman's method	B	6.6	pIC50	249	nM	IC50	Bioorg Med Chem (2013) 21: 676-683 [PMID:23273608]
ChEMBL	Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate by Ellman's method	B	6.63	pIC50	237	nM	IC50	Eur J Med Chem (2021) 226: 113827-113827 [PMID:34530383]
ChEMBL	Inhibition of AChE in rat cortex using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate addition by Ellman's colorimetric method	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem (2013) 21: 1064-1073 [PMID:23380475]
ChEMBL	Inhibition of acetylcholinesterase	B	6.64	pIC50	230	nM	IC50	Bioorg Med Chem Lett (1992) 2: 865-870
ChEMBL	Inhibition of rat cortex AChE	B	6.65	pIC50	223	nM	IC50	J Med Chem (2008) 51: 3588-3598 [PMID:18517184]
ChEMBL	Inhibitory concentration against rat cortex Acetylcholinesterase	B	6.65	pIC50	223	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4639-4642 [PMID:15324879]
ChEMBL	Inhibition of rat brain AChE	B	6.65	pIC50	223	nM	IC50	J Med Chem (2006) 49: 5491-5500 [PMID:16942022]
ChEMBL	Inhibitory potency against acetylcholinesterase (AChE) of rat cortex homogenate with ethopropazine as BChE inhibitor	B	6.65	pIC50	223	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2335-2338 [PMID:10476864]
ChEMBL	Inhibition of rat brain acetylcholine esterase in presence of acetylcholine substrate by chemiluminescent assay	B	6.7	pIC50	200	nM	IC50	Eur J Med Chem (2008) 43: 657-661 [PMID:17624631]
ChEMBL	Inhibitory activity against acetylcholinesterase in rat brain	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (1996) 6: 737-742
ChEMBL	Compound was tested in vitro for inhibitory activity against Acetylcholinesterase in rat cortex	B	6.7	pIC50	200	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2599-2602
ChEMBL	Inhibition of Sprague-Dawley rat acetylcholinesterase using acetylthiocholine iodide as substrate measured at 30 secs for 5 mins by Ellman's method	B	6.77	pIC50	170	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127498-127498 [PMID:32818604]
ChEMBL	Inhibitory activity against rat brain total Acetylcholinesterase (AChE) was determined using Ellman's method	B	6.8	pIC50	160	nM	IC50	J Med Chem (2003) 46: 1144-1152 [PMID:12646025]
ChEMBL	Inhibition of rat cortex acetylcholinesterase using acetylthiocholine iodide as substrate incubated for 20 mins by Ellman's method	B	6.88	pIC50	131	nM	IC50	Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL	Inhibition of rat cortex AChE using acetylthiocholine iodide as substrate after 20 mins by by Ellman's method	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem (2018) 26: 3117-3125 [PMID:29729987]
ChEMBL	Inhibition of Wistar rat brain AChE using acetylthiochloline iodide as substrate after 30 mins by Ellman's method	B	6.94	pIC50	114.32	nM	IC50	Eur J Med Chem (2016) 121: 758-772 [PMID:27392529]
ChEMBL	Inhibition against acetylcholinesterase (AChE)	B	6.96	pIC50	110	nM	IC50	J Med Chem (1994) 37: 689-695 [PMID:8126709]
ChEMBL	Inhibition of rat cortex homogenate acetylcholinesterase by spectrophotometric method	B	7.03	pIC50	93	nM	IC50	Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080]
ChEMBL	Inhibition of AChE from rat cortex by Ellman assay	B	7.06	pIC50	88	nM	IC50	Eur J Med Chem (2010) 45: 526-535 [PMID:19954865]
ChEMBL	Inhibitory concentration in vitro and ex vivo for anti-AChE activity in rat brain	B	7.09	pIC50	80.6	nM	IC50	Bioorg Med Chem Lett (1992) 2: 871-876
ChEMBL	In vitro inhibition of acetylcholinesterase, isolated from rat brain.	B	7.11	pIC50	78	nM	IC50	J Med Chem (1997) 40: 3516-3523 [PMID:9357518]
ChEMBL	In vitro inhibitory effect on rat Acetylcholinesterase	B	7.2	pIC50	63	nM	IC50	J Med Chem (1995) 38: 2969-2973 [PMID:7636858]
ChEMBL	Inhibition of Acetylcholinesterase in rat red blood cell	B	7.34	pIC50	46	nM	IC50	J Med Chem (1996) 39: 3014-3018 [PMID:8709135]
carboxylesterase 1/Acyl coenzyme A:cholesterol acyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2265] [GtoPdb: 2592] [UniProtKB: P23141]
ChEMBL	Inhibition of human carboxylesterase 1 using o-nitrophenylacetate as substrate by spectrophotometry analysis	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2016) 24: 1050-1062 [PMID:26827140]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)	B	5.95	pKi	1113	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin)	B	5.56	pIC50	2749	nM	IC50	DrugMatrix in vitro pharmacology data
Beta amyloid A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Inhibition of self-mediated amyloid beta (1 to 42) (unknown origin) aggregation after 24 hrs by thioflavin T fluorescence assay	B	7.91	pIC50	12.21	nM	IC50	Eur J Med Chem (2016) 116: 200-209 [PMID:27061983]
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
GtoPdb	-	-	7.2	pKi	70	nM	Ki	J Med Chem (2008) 51: 3154-70 [PMID:18479118]
ChEMBL	Inhibition of human recombinant BChE using acetylthiocholine as substrate	B	8.06	pKi	8.72	nM	Ki	Bioorg Med Chem (2012) 20: 6739-6750 [PMID:23041347]
ChEMBL	Inhibition of human BChE assessed as acetylthiocholine hydrolysis	B	8.06	pKi	8.7	nM	Ki	Bioorg Med Chem (2014) 22: 4784-4791 [PMID:25088549]
ChEMBL	Inhibition of human BuChE	B	8.15	pKi	7	nM	Ki	J Med Chem (2006) 49: 3421-3425 [PMID:16722663]
ChEMBL	Inhibition of human recombinant BChE	B	8.15	pKi	7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 5213-5216 [PMID:18786825]
ChEMBL	Inhibition of human recombinant BuChE	B	8.15	pKi	7	nM	Ki	J Med Chem (2008) 51: 3154-3170 [PMID:18479118]
ChEMBL	Inhibition of Butyrylcholinesterase (BChE) of human erythrocytes [-log IC50 (uM)]	B	6.44	pIC50	363.08	nM	IC50	J Med Chem (1998) 41: 4186-4189 [PMID:9784091]
ChEMBL	Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by spectrophotometry based Ellman's method	B	6.8	pIC50	158.49	nM	IC50	J Med Chem (2019) 62: 9078-9102 [PMID:31609608]
ChEMBL	Inhibition of human Cholinesterase	B	7.02	pIC50	95	nM	IC50	Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL	Concentration that causes 50% inhibition of Butyrylcholinesterase (BChE) using human serum and BW284c51	B	7.05	pIC50	89	nM	IC50	J Med Chem (2002) 45: 2277-2282 [PMID:12014965]
ChEMBL	Inhibition of human plasmatic BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 2 mins time interval by Ellman's method	B	7.06	pIC50	88.1	nM	IC50	Eur J Med Chem (2018) 150: 292-306 [PMID:29533874]
ChEMBL	Inhibition of human BuChE using butyrylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based Ellman's method	B	7.07	pIC50	85	nM	IC50	Eur J Med Chem (2021) 210: 113059-113059 [PMID:33310288]
ChEMBL	Inhibition of recombinant human BuChE using butyrylthiocholine as substrate by Ellman's method	B	7.1	pIC50	80	nM	IC50	Bioorg Med Chem Lett (2021) 43: 128100-128100 [PMID:33984470]
ChEMBL	Inhibition of human plasmatic BuChE assessed as reduction in cholinesterase activity by Ellman's method	B	7.1	pIC50	80	nM	IC50	Eur J Med Chem (2021) 219: 113434-113434 [PMID:33892271]
ChEMBL	Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method	B	7.1	pIC50	80	nM	IC50	Eur J Med Chem (2019) 168: 491-514 [PMID:30851693]
ChEMBL	Inhibition of human plasmatic BChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured every 2 mins by Ellman's method	B	7.1	pIC50	80	nM	IC50	J Med Chem (2015) 58: 8985-9003 [PMID:26503905]
ChEMBL	Inhibition of human recombinant serum BuchE using butyrylthiocholine iodide as substrate by Ellman method	B	7.14	pIC50	73	nM	IC50	Bioorg Med Chem Lett (2015) 25: 830-833 [PMID:25597004]
ChEMBL	Inhibition of recombinant human serum BChE using butyrylthiocholine iodide as substrate by spectroscopic Ellmans method	B	7.14	pIC50	73	nM	IC50	Eur J Med Chem (2011) 46: 2193-2205 [PMID:21435752]
ChEMBL	Inhibition of human erythrocyte BuChE using S-butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured every 30 secs for 1 hr by Ellman's method	B	7.15	pIC50	70	nM	IC50	J Nat Prod (2019) 82: 3221-3226 [PMID:31736307]
ChEMBL	Inhibition of BChE (unknown origin) incubated for 10 mins by Ellman's method	B	7.18	pIC50	66	nM	IC50	Bioorg Med Chem Lett (2019) 29: 126754-126754 [PMID:31708262]
ChEMBL	Inhibition of human recombinant BuChE by Ellman's assay	B	7.24	pIC50	58	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6254-6258 [PMID:24140444]
ChEMBL	Inhibition of human serum BuChE by Ellman's method	B	7.24	pIC50	58	nM	IC50	J Med Chem (2007) 50: 5311-5323 [PMID:17902635]
ChEMBL	Inhibition of human BChE using butyrylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's method	B	7.27	pIC50	54	nM	IC50	J Med Chem (2021) 64: 9302-9320 [PMID:34152756]
ChEMBL	Inhibitory concentration against butyrylcholinesterase from human serum	B	7.27	pIC50	53.7	nM	IC50	J Med Chem (2003) 46: 954-966 [PMID:12620072]
ChEMBL	Inhibition of human BChE using butyrylthiocholineiodide as substrate incubated for 10 mins by Ellman's method	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2021) 30: 115940-115940 [PMID:33340937]
ChEMBL	Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229]
ChEMBL	Inhibition of BuChE in human serum using butyrylthiocholine iodide as substrate measured every 30s for 5 mins by Ellman's spectrophotometric method	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2014) 75: 21-30 [PMID:24508831]
ChEMBL	Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's method	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2011) 46: 4336-4343 [PMID:21798635]
ChEMBL	Inhibitory concentration against human plasma Butyrylcholinesterase	B	7.33	pIC50	47	nM	IC50	J Med Chem (2005) 48: 986-994 [PMID:15715468]
ChEMBL	Ex vivo inhibition of human plasma Butyrylcholinesterase.	B	7.33	pIC50	47	nM	IC50	J Med Chem (2002) 45: 3684-3691 [PMID:12166941]
ChEMBL	Anticholinesterase activity against human plasma BChE	B	7.33	pIC50	47	nM	IC50	J Med Chem (2006) 49: 2174-2185 [PMID:16570913]
ChEMBL	Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate by Ellman's method	B	7.34	pIC50	46	nM	IC50	Eur J Med Chem (2012) 52: 251-262 [PMID:22503231]
ChEMBL	Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured after 5 mins by Ellman's method	B	7.34	pIC50	46	nM	IC50	Eur J Med Chem (2014) 73: 141-152 [PMID:24389509]
ChEMBL	Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition measured for 3 mins by Ellman's method	B	7.34	pIC50	46	nM	IC50	Eur J Med Chem (2017) 141: 197-210 [PMID:29031067]
ChEMBL	Inhibition of human serum recombinant BChE by Ellman's method	B	7.34	pIC50	45.8	nM	IC50	J Med Chem (2007) 50: 6446-6449 [PMID:18047264]
ChEMBL	Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method	B	7.34	pIC50	45.8	nM	IC50	J Med Chem (2021) 64: 4972-4990 [PMID:33829779]
ChEMBL	Inhibition of Butyrylcholinesterase	B	7.34	pIC50	45.8	nM	IC50	J Med Chem (2005) 48: 24-27 [PMID:15633997]
ChEMBL	Inhibitory concentration against human recombinant butyrylcholinesterase	B	7.34	pIC50	45.8	nM	IC50	J Med Chem (2005) 48: 360-363 [PMID:15658850]
ChEMBL	Inhibition of human recombinant butyrylcholinesterase	B	7.34	pIC50	45.8	nM	IC50	J Med Chem (2007) 50: 4882-4897 [PMID:17850125]
ChEMBL	Inhibition of human serum BChE by Ellman's method	B	7.34	pIC50	45.8	nM	IC50	J Med Chem (2008) 51: 4381-4384 [PMID:18605718]
ChEMBL	Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's method	B	7.34	pIC50	45.8	nM	IC50	J Med Chem (2016) 59: 114-131 [PMID:26632651]
ChEMBL	Inhibition of human recombinant BChE	B	7.34	pIC50	45.71	nM	IC50	J Med Chem (2004) 47: 6490-6498 [PMID:15588084]
ChEMBL	Inhibition of human BuChE at 10 uM	B	7.35	pIC50	45	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127609-127609 [PMID:33039562]
ChEMBL	Inhibition of recombinant human serum BChE using butyrylthiocholine as substrate pretreated for 20 mins followed by substrate addition by Ellman's method	B	7.35	pIC50	44.2	nM	IC50	Eur J Med Chem (2018) 155: 839-846 [PMID:29958119]
ChEMBL	Inhibition of human serum BuChe by Ellman's method	B	7.35	pIC50	44.2	nM	IC50	Eur J Med Chem (2019) 181: 111550-111550 [PMID:31376562]
ChEMBL	Inhibition of human BuchE	B	7.36	pIC50	44	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127075-127075 [PMID:32165042]
ChEMBL	Inhibition of human serum BChE	B	7.36	pIC50	43.9	nM	IC50	J Med Chem (2006) 49: 6833-6840 [PMID:17154513]
ChEMBL	Inhibition of butyrylcholinesterase (BChE) activity in human serum	B	7.36	pIC50	43.9	nM	IC50	J Med Chem (1999) 42: 3227-3242 [PMID:10464010]
ChEMBL	Inhibition of butyrylcholinesterase (BChE) in human serum	B	7.36	pIC50	43.9	nM	IC50	J Med Chem (2000) 43: 4657-4666 [PMID:11101357]
ChEMBL	Inhibition of human BChE using butyrylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition by Ellman's method	B	7.37	pIC50	42.66	nM	IC50	J Med Chem (2021) 64: 9302-9320 [PMID:34152756]
ChEMBL	Inhibition of human serum BuChE using s-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method	B	7.39	pIC50	41	nM	IC50	Eur J Med Chem (2016) 123: 282-297 [PMID:27484514]
ChEMBL	Inhibition of human serum BChE by Ellman's reaction	B	7.4	pIC50	40	nM	IC50	J Med Chem (2010) 53: 4927-4937 [PMID:20545360]
ChEMBL	Inhibition of human serum BChE by Ellman's method	B	7.4	pIC50	40	nM	IC50	J Med Chem (2012) 55: 1303-1317 [PMID:22243648]
ChEMBL	Inhibition of human BuChE using butyrylthiocholine iodide as substrate incubated for 10 mins prior to substrate addition measured after 15 mins by Ellman's method	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2012) 54: 750-763 [PMID:22795665]
ChEMBL	Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate treated 5 mins before substrate addition measured up to 4 mins by Ellman's method	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2013) 23: 4336-4341 [PMID:23791077]
ChEMBL	Inhibition of human BuChE	B	7.4	pIC50	40	nM	IC50	J Med Chem (2006) 49: 459-462 [PMID:16420031]
ChEMBL	Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured over 5 mins by UV-Vis spectrophotometric analysis	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2017) 139: 773-791 [PMID:28863358]
ChEMBL	Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 60 to 300 sec by Ellman's method	B	7.4	pIC50	40	nM	IC50	Medchemcomm (2015) 6: 1930-1941
ChEMBL	Inhibition of human serum BChE using butyrylthiocholine iodide as substrate pre-incubated for 20 mins before substrate addition and measured for 180 secs by spectrophotometry based Ellman's method	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2019) 167: 161-186 [PMID:30771604]
ChEMBL	Inhibition of human serum BuChE using butyrylthiocholine as substrate pretreated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2018) 158: 781-800 [PMID:30245401]
ChEMBL	Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured for 5 mins by Ellman's assay	B	7.4	pIC50	40	nM	IC50	Medchemcomm (2017) 8: 1307-1317 [PMID:30108842]
ChEMBL	Inhibition of human BuChE using butyrylthiocholine iodide as substrate incubated for 20 mins followed by substrate addition measured after 2 mins by Ellman's method	B	7.4	pIC50	40	nM	IC50	ACS Med Chem Lett (2018) 9: 171-176 [PMID:29541355]
ChEMBL	Inhibition of human BuChE in serum	B	7.4	pIC50	40	nM	IC50	J Med Chem (2009) 52: 7249-7257 [PMID:19856923]
ChEMBL	Inhibition of human BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 1 min followed by substrate addition and measured after 10 mins by Ellman's method	B	7.4	pIC50	39.6	nM	IC50	Eur J Med Chem (2020) 207: 112751-112751 [PMID:32950908]
ChEMBL	Inhibition of human serum BuchE using butyrylthiocholine iodide as substrate preincubated for 10 mins measured after 15 mins of substrate addition by Ellman's method	B	7.44	pIC50	36	nM	IC50	J Med Chem (2011) 54: 8251-8270 [PMID:22023459]
ChEMBL	Inhibition of human serum BuChE by Ellman's method	B	7.44	pIC50	36	nM	IC50	Bioorg Med Chem (2008) 16: 7759-7769 [PMID:18640842]
ChEMBL	Inhibition of human serum BChE by Ellman's method	B	7.44	pIC50	36	nM	IC50	J Med Chem (2009) 52: 2724-2732 [PMID:19374444]
ChEMBL	Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate by Ellman's methods	B	7.44	pIC50	36	nM	IC50	Eur J Med Chem (2019) 166: 381-389 [PMID:30739821]
ChEMBL	Inhibition of BuChE (unknown origin)	B	7.44	pIC50	36	nM	IC50	Eur J Med Chem (2019) 166: 381-389 [PMID:30739821]
ChEMBL	Inhibition of human serum BuChE	B	7.44	pIC50	36	nM	IC50	J Med Chem (2006) 49: 7607-7610 [PMID:17181144]
ChEMBL	Inhibition of recombinant human BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method	B	7.45	pIC50	35.2	nM	IC50	J Med Chem (2020) 63: 9360-9390 [PMID:32706255]
ChEMBL	Inhibition of human serum BCHE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by DTNB addition for 5 mins and subsequent addition of substrate measured after 3 mins by Ellman's method	B	7.46	pIC50	34.4	nM	IC50	Eur J Med Chem (2018) 148: 238-254 [PMID:29466774]
ChEMBL	Inhibition of human BuChE by spectrophotometric based Ellman's method	B	7.47	pIC50	34	nM	IC50	Eur J Med Chem (2020) 207: 112743-112743 [PMID:32882609]
ChEMBL	Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated followed by substrate addition by Ellman's method	B	7.47	pIC50	34	nM	IC50	Bioorg Med Chem (2016) 24: 1050-1062 [PMID:26827140]
ChEMBL	Inhibition of human BuchE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by Ellman's method	B	7.47	pIC50	34	nM	IC50	Eur J Med Chem (2021) 218: 113397-113397 [PMID:33838585]
ChEMBL	Inhibition of BuChE in human plasma using BTC as substrate preincubated with enzyme for 5 mins followed by substrate addition for 5 mins by Ellman's method	B	7.47	pIC50	33.6	nM	IC50	Eur J Med Chem (2021) 225: 113792-113792 [PMID:34530376]
ChEMBL	Inhibition of human serum BChE using BTCh as substrate preincubated for 20 mins followed by substrate addition and measured for 3 mins by Ellman's method	B	7.47	pIC50	33.5	nM	IC50	Eur J Med Chem (2019) 168: 58-77 [PMID:30798053]
ChEMBL	Inhibition of human BChE by Ellman's method	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2007) 15: 6596-6607 [PMID:17681794]
ChEMBL	Inhibition of human serum BCHE preincubated for 6 mins followed by addition of S-butyrylcholine iodide as substrate by Ellman's method	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem (2016) 24: 4324-4338 [PMID:27460699]
ChEMBL	Inhibitory concentration against butyrylcholinesterase	B	7.57	pIC50	27	nM	IC50	J Med Chem (2005) 48: 3564-3575 [PMID:15887964]
ChEMBL	Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman method	B	7.6	pIC50	25.33	nM	IC50	Eur J Med Chem (2015) 95: 153-165 [PMID:25812965]
ChEMBL	Inhibition of BuChE in human erythrocyte hemo-lyzates pre-incubated for 5 mins before addition of butyrylthiocholine iodide substrate by Ellman's method	B	7.6	pIC50	25	nM	IC50	J Med Chem (2016) 59: 9967-9973 [PMID:27736061]
ChEMBL	In vitro inhibition of Butyrylcholinesterase from human plasma.	B	7.6	pIC50	25	nM	IC50	J Med Chem (1997) 40: 3516-3523 [PMID:9357518]
ChEMBL	Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins prior substrate addition measured after 5 mins by spectrophotometry	B	7.61	pIC50	24.5	nM	IC50	J Med Chem (2012) 55: 661-669 [PMID:22185619]
ChEMBL	Inhibition of human serum BChE by Ellman's assay	B	7.62	pIC50	24	nM	IC50	J Med Chem (2008) 51: 3588-3598 [PMID:18517184]
ChEMBL	Inhibition of human serum BChE	B	7.62	pIC50	24	nM	IC50	J Med Chem (2005) 48: 7223-7233 [PMID:16279781]
ChEMBL	Inhibition of human serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's method	B	7.63	pIC50	23.2	nM	IC50	Eur J Med Chem (2015) 93: 42-50 [PMID:25656088]
ChEMBL	Inhibition of human BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured for 1 min by Ellman's assay	B	7.63	pIC50	23.2	nM	IC50	Eur J Med Chem (2018) 156: 598-617 [PMID:30031971]
ChEMBL	Inhibition of human BChE after 20 mins using butyrylthiocholine iodide as a substrate by Ellman's assay	B	7.64	pIC50	23	nM	IC50	J Med Chem (2011) 54: 2627-2645 [PMID:21417225]
ChEMBL	Inhibition of human plasmatic BChE after 5 mins using spectrophotometer by Ellman's method	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2011) 21: 6563-6566 [PMID:21920739]
ChEMBL	In vitro Butyrylcholinesterase inhibitory activity to determine its ability to reverse the cholinergic deficit characteristic of AD	B	7.64	pIC50	23	nM	IC50	J Med Chem (1992) 35: 3141-3147 [PMID:1507203]
ChEMBL	Inhibition of human recombinant BuChe using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition measured for 1 min by Ellman's method	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem (2017) 25: 633-645 [PMID:27908752]
ChEMBL	The compound was evaluated for the inhibition human of Butyrylcholinesterase I	B	7.64	pIC50	23	nM	IC50	J Med Chem (1992) 35: 1102-1108 [PMID:1552502]
ChEMBL	Inhibition of human plasmatic BChE after 5 mins by Ellman method	B	7.64	pIC50	23	nM	IC50	J Med Chem (2014) 57: 8576-8589 [PMID:25259726]
ChEMBL	Inhibition of human plasmatic BChE after 5 mins	B	7.64	pIC50	23	nM	IC50	Bioorg Med Chem Lett (2010) 20: 6093-6095 [PMID:20817518]
ChEMBL	Inhibition of human BuChE pre-incubated for 5 mins before butylthiocholine substrate addition by Ellman's method	B	7.64	pIC50	23	nM	IC50	J Med Chem (2014) 57: 7073-7084 [PMID:25089370]
ChEMBL	Inhibition of human plasma BuChE using S-butyrylthiocholine iodide as substrate after 30 mins by Ellman's method	B	7.64	pIC50	22.73	nM	IC50	Eur J Med Chem (2016) 121: 758-772 [PMID:27392529]
ChEMBL	Inhibition of butyrylcholinesterase from human serum	B	7.68	pIC50	21	nM	IC50	J Med Chem (2001) 44: 2707-2718 [PMID:11495583]
ChEMBL	Inhibitory concentration against Butyrylcholinesterase (BuChE) from human serum	B	7.68	pIC50	21	nM	IC50	J Med Chem (1999) 42: 730-741 [PMID:10052979]
ChEMBL	Inhibition of butyrylcholinesterase (unknown origin)	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476]
ChEMBL	Inhibition of human serum BuChE using butylthiocholine chloride as substrate pretreated for 15 mins followed by substrate addition measured for 2 mins by DTNB reagent based spectrophotometric method	B	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2017) 130: 139-153 [PMID:28242549]
ChEMBL	Inhibition of human serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured at 1 min time interval by Ellman's method relative to control	B	7.7	pIC50	20	nM	IC50	Eur J Med Chem (2019) 167: 133-145 [PMID:30771601]
ChEMBL	Inhibition of human BuChE using butyrylthiocholine iodide as substrate incubated for 20 mins prior to substrate addition measured for 1 hr by Ellman's method	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem (2013) 21: 4218-4224 [PMID:23719283]
ChEMBL	Inhibition of human BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 1 min by Ellman's method	B	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2017) 128: 237-246 [PMID:28189905]
ChEMBL	Inhibition of human BChE	B	7.9	pIC50	12.59	nM	IC50	J Med Chem (2019) 62: 9078-9102 [PMID:31609608]
ChEMBL	Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition measured for 1 min by Ellman's method	B	7.92	pIC50	12	nM	IC50	Eur J Med Chem (2016) 123: 298-308 [PMID:27484515]
ChEMBL	Inhibition of BChE	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144]
ChEMBL	Inhibition of recombinant human BChE by Ellman method	B	7.92	pIC50	12	nM	IC50	J Med Chem (2014) 57: 8167-8179 [PMID:25226236]
ChEMBL	Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate after 5 mins by Ellman's method	B	7.92	pIC50	12	nM	IC50	Bioorg Med Chem (2015) 23: 4442-4452 [PMID:26116179]
ChEMBL	Inhibition of human BChE pre-incubated for 6 mins before ATCI substrate addition and measured after 12 mins by DTNB reagent dependent UV-Vis spectrophotometry based Ellman's method	B	7.97	pIC50	10.8	nM	IC50	Eur J Med Chem (2017) 140: 118-127 [PMID:28923380]
ChEMBL	Inhibitory concentration against Butyrylcholinesterase activity	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2005) 15: 353-356 [PMID:15603953]
ChEMBL	Inhibition of human BChE using BTC iodide as substrate preincubated for 4.5 mins followed by substrate addition measured after 2.5 mins by Ellman's method	B	8	pIC50	10	nM	IC50	J Med Chem (2018) 61: 1646-1663 [PMID:29400965]
ChEMBL	Inhibition of human BChE using BTC iodide as substrate preincubated for 4.5 mins followed by substrate addition measured after 2.5 mins by Ellman's method	B	8.04	pIC50	9.1	nM	IC50	J Med Chem (2018) 61: 1646-1663 [PMID:29400965]
ChEMBL	In vitro inhibition of Butyrylcholinesterase from human erythrocytes	B	8.22	pIC50	6	nM	IC50	J Med Chem (1995) 38: 2802-2808 [PMID:7636841]
ChEMBL	Concentration required to inhibit 50% of Butyrylcholinesterase obtained from human serum was determined in vitro	B	8.22	pIC50	6	nM	IC50	J Med Chem (1995) 38: 1084-1089 [PMID:7707311]
ChEMBL	Inhibition of BuChE by Ellman's assay	B	8.29	pIC50	5.1	nM	IC50	J Med Chem (2008) 51: 713-716 [PMID:18232655]
ChEMBL	In vitro inhibitory activity against Butyrylcholinesterase (BChE) in human serum	B	9.05	pIC50	0.9	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2389-2391 [PMID:12824041]
ChEMBL	Inhibition of BChE by Ellman's method	B	10.57	pIC50	0.03	nM	IC50	Eur J Med Chem (2011) 46: 3250-3257 [PMID:21570751]
Butyrylcholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9]
ChEMBL	Inhibition of Equine Butyrylcholinesterase	B	8.15	pKi	7	nM	Ki	J Med Chem (2003) 46: 1-4 [PMID:12502352]
ChEMBL	Inhibition of equine (Eq) Butyrylcholinesterase	B	8.15	pKi	7	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1779-1782 [PMID:11425559]
ChEMBL	Dissociation constant for inhibition of equine Butyrylcholinesterase (BuChE)	B	8.15	pKi	7	nM	Ki	J Med Chem (2005) 48: 1919-1929 [PMID:15771436]
ChEMBL	Inhibition of equine BChE after 15 mins by Ellman's method using acetylcholine as substrate	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem Lett (2010) 20: 6649-6652 [PMID:20880702]
ChEMBL	Inhibition of equine BChE by Ellman's method	B	7.57	pIC50	27.08	nM	IC50	Bioorg Med Chem (2011) 19: 763-770 [PMID:21211982]
ChEMBL	Inhibition of equine BChE preincubated for 15 mins by Ellman's method	B	7.82	pIC50	15.2	nM	IC50	Eur J Med Chem (2014) 87: 429-439 [PMID:25282266]
ChEMBL	Inhibition of BuChE from horse serum	B	8	pIC50	10	nM	IC50	J Med Chem (2006) 49: 459-462 [PMID:16420031]
ChEMBL	Compound was evaluated for the in vitro inhibition of the Butyrylcholinesterase from horse serum	B	8.22	pIC50	6	nM	IC50	J Med Chem (1994) 37: 2721-2734 [PMID:8064800]
ChEMBL	Inhibition Assay: The inhibitory activity of the enzyme acetylcholinesterase (AChE) was evaluated by the Ellman method (Biochem. Pharmacol. 1961, 7, 88) using an electric eel as an AChE neuronal model (Electrophorus electricus) and acetylthiocholine iodide (0.35 mM) as substrate. The reaction took place in a final volume of 3 mL of a 0.1 M phosphate buffer solution, pH 8.0, containing 0.035 units of AChE and used a 0.35 mM solution of 5,5'-dithio-bis(2-nitrobenzoic acid) (DTNB) to produce the 5-thio-2-nitrobenzoic acid anion. Inhibition curves were performed in triplicate by incubating at least nine inhibitor concentrations for 10 min. A triplicate sample without inhibitor was always present so as to be aware of 100% of the AChE activity. After this time, the substrate was added to 0.35 mM acetylthiocholine iodide, from a 10 mM stock solution. Loss of color was observed at 412 nm in a spectrophotometric reader having 96 well plates.	B	8.28	pIC50	5.2	nM	IC50	US-8999994-B2. Derivatives of propargylamine having neuroprotective capacity for the treatment of Alzheimer's and Parkinson's diseases (2015)
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 15 mins by Ellman's method	B	8.28	pIC50	5.2	nM	IC50	Eur J Med Chem (2012) 52: 251-262 [PMID:22503231]
ChEMBL	Inhibition of (BChE) Butyrylcholinesterase of horse serum	B	8.29	pIC50	5.17	nM	IC50	Bioorg Med Chem Lett (1992) 2: 861-864
ChEMBL	Inhibition of equine BChE by Ellman's assay	B	8.29	pIC50	5.1	nM	IC50	Bioorg Med Chem Lett (2008) 18: 2905-2909 [PMID:18406135]
ChEMBL	Inhibition of BuChE from equine serum	B	8.29	pIC50	5.1	nM	IC50	J Med Chem (2008) 51: 7666-7669 [PMID:19053746]
butyrylcholinesterase/Butyrylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2528] [GtoPdb: 2471] [UniProtKB: Q03311]
ChEMBL	Inhibition of BuChE in Swiss Webster mouse whole blood serum using butyrylthiocholine iodide as substrate preincubated for 10 mins followed substrate addition measured after 10 mins by Ellman's method	B	7.2	pIC50	62.5	nM	IC50	Bioorg Med Chem (2018) 26: 5566-5577 [PMID:30340901]
ChEMBL	Inhibition of BuChE in Swiss mouse serum using butyrylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition and measured after 10 mins	B	7.22	pIC50	60	nM	IC50	Medchemcomm (2019) 10: 2089-2101 [PMID:32904099]
Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1]
ChEMBL	Inhibitory concentration against rat brain butyrylcholinesterase (BuChE) was determined using Ellman's method	B	6.62	pIC50	240	nM	IC50	J Med Chem (2003) 46: 1144-1152 [PMID:12646025]
ChEMBL	Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate by Ellman's method	B	6.83	pIC50	147	nM	IC50	Eur J Med Chem (2021) 226: 113827-113827 [PMID:34530383]
ChEMBL	Inhibition of rat serum BuChE	B	7.04	pIC50	92	nM	IC50	J Med Chem (2006) 49: 5491-5500 [PMID:16942022]
ChEMBL	Inhibitory potency against rat serum Butyrylcholinesterase with BW284c51 as AChE inhibitor	B	7.04	pIC50	92	nM	IC50	Bioorg Med Chem Lett (1999) 9: 2335-2338 [PMID:10476864]
ChEMBL	Inhibitory concentration against rat serum Butyrylcholinesterase	B	7.04	pIC50	92	nM	IC50	Bioorg Med Chem Lett (2004) 14: 4639-4642 [PMID:15324879]
ChEMBL	Inhibition of rat serum BChE	B	7.04	pIC50	92	nM	IC50	J Med Chem (2008) 51: 3588-3598 [PMID:18517184]
ChEMBL	Inhibition of rat serum BChE using butyrylthiocholine iodide as substrate after 20 mins by by Ellman's method	B	7.1	pIC50	80	nM	IC50	Bioorg Med Chem (2018) 26: 3117-3125 [PMID:29729987]
ChEMBL	Inhibition of rat cortex homogenate BuChE by spectrophotometric method	B	7.13	pIC50	74	nM	IC50	Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080]
ChEMBL	Butyrylcholinesterase	B	7.14	pIC50	73	nM	IC50	J Med Chem (1995) 38: 4821-4829 [PMID:7490731]
ChEMBL	In vitro inhibitory concentration against Butyrylcholinesterase obtained from rat plasma	B	7.14	pIC50	73	nM	IC50	J Med Chem (1992) 35: 4542-4548 [PMID:1469686]
ChEMBL	Inhibitory concentration was determined in in vitro for Butyrylcholinesterase in rat plasma	B	7.14	pIC50	73	nM	IC50	Bioorg Med Chem Lett (1992) 2: 871-876
ChEMBL	Compound was tested in vitro for inhibitory activity against Butyrylcholinesterase	B	7.26	pIC50	54.7	nM	IC50	Bioorg Med Chem Lett (1997) 7: 2599-2602
ChEMBL	Inhibition of rat serum butyrylcholinesterase using butyrylthiocholine as substrate in presence of AChE inhibitor BW284C51 by spectrophotometric method	B	7.36	pIC50	44	nM	IC50	Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL	Inhibition of rat plasma butyrylcholine esterase in presence of butyrylcholine substrate by chemiluminescent assay	B	8.05	pIC50	9	nM	IC50	Eur J Med Chem (2008) 43: 657-661 [PMID:17624631]
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Displacement of [3H]CP-55940 from human CB1 receptor expressed in CHO cells	B	6	pKi	>1000	nM	Ki	J Med Chem (2010) 53: 1338-1346 [PMID:20047331]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
ChEMBL	Displacement of [3H]CP-55940 from human CB2 receptor expressed in CHO cells	B	6	pKi	>1000	nM	Ki	J Med Chem (2010) 53: 1338-1346 [PMID:20047331]
choline O-acetyltransferase/Choline acetylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3945] [GtoPdb: 2480] [UniProtKB: P32738]
ChEMBL	Inhibition constant determined against Acetylcholinesterase (AChE) receptor.	B	9.82	pKi	0.15	nM	Ki	J Med Chem (1998) 41: 4186-4189 [PMID:9784091]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL	Competitive inhibition of equine serum BuChE assessed as enzyme-inhibitor complex using p-nitrophenyl butyrate as substrate by Lineweaver-Burk plot analysis	B	7.76	pKi	17.2	nM	Ki	Eur J Med Chem (2017) 138: 761-773 [PMID:28728108]
ChEMBL	Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-inhibitor complex using butyrylthiocholine iodide as substrate measured for 125 secs by Ellman's method	B	7.77	pKi	17	nM	Ki	Eur J Med Chem (2019) 181: 111550-111550 [PMID:31376562]
ChEMBL	Inhibition of equine serum BuChE by Ellman's method	B	4.97	pIC50	10800	nM	IC50	Bioorg Med Chem Lett (2021) 49: 128212-128212 [PMID:34153471]
ChEMBL	Inhibition of horse serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins by Ellman method	B	5.09	pIC50	8130	nM	IC50	Bioorg Med Chem (2015) 23: 2445-2457 [PMID:25868744]
ChEMBL	Inhibition of horse serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method	B	5.75	pIC50	1770	nM	IC50	Eur J Med Chem (2016) 107: 219-232 [PMID:26588065]
ChEMBL	Inhibition of equine serum BChE pre-incubated for 5 mins before butyrylthiocholineiodide substrate addition by Ellman's method	B	6.09	pIC50	820	nM	IC50	Bioorg Med Chem Lett (2015) 25: 3442-3446 [PMID:26212777]
ChEMBL	Inhibition of equine serum BuChE pre-incubated for 3 mins before butyrylthiocholine substrate addition by Ellman's reagent based spectrophotometry	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2015) 97: 181-189 [PMID:25969170]
ChEMBL	Inhibition of equine serum BuChE using butylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	B	6.46	pIC50	350	nM	IC50	Eur J Med Chem (2015) 89: 296-303 [PMID:25462245]
ChEMBL	Inhibition of equine serum BuchE using butyrylthiocholine as substrate by Ellman's method	B	6.67	pIC50	216	nM	IC50	Bioorg Med Chem Lett (2019) 29: 2150-2152 [PMID:31281020]
ChEMBL	Inhibition of equine BuchE using butyrylthiocholine as substrate by Ellman's method	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127075-127075 [PMID:32165042]
ChEMBL	Inhibition of horse serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins by Ellman's method	B	7	pIC50	100	nM	IC50	Bioorg Med Chem Lett (2012) 22: 6498-6502 [PMID:22981331]
ChEMBL	Inhibition of horse serum BChE after 15 mins by DTNB reagent based assay	B	7.18	pIC50	66	nM	IC50	Medchemcomm (2018) 9: 149-159 [PMID:30108908]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by spectroscopy based Ellman's method	B	7.25	pIC50	56	nM	IC50	Eur J Med Chem (2017) 136: 36-51 [PMID:28478343]
ChEMBL	Inhibition of equine serum BuChE preincubated for 5 mins followed by addition of butyrylthiocholine iodide as substrate measured after 2 mins by Ellman's method	B	7.27	pIC50	54	nM	IC50	Eur J Med Chem (2016) 119: 260-277 [PMID:27227482]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate incubated for 5 mins followed by substrate addition and measured after 2 mins by Ellman's method	B	7.27	pIC50	54	nM	IC50	Bioorg Med Chem (2016) 24: 2777-2788 [PMID:27157006]
ChEMBL	Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method	B	7.27	pIC50	54	nM	IC50	Bioorg Med Chem Lett (2013) 23: 2636-2641 [PMID:23511019]
ChEMBL	Inhibition of horse BuChE using S-butyrylcholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method	B	7.28	pIC50	52	nM	IC50	Medchemcomm (2014) 5: 609-616
ChEMBL	Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate incubated for 6 mins by spectrophotometric method	B	7.3	pIC50	50.5	nM	IC50	Bioorg Med Chem (2014) 22: 6089-6104 [PMID:25282654]
ChEMBL	Inhibition of equine serum BuChE using S-butyrylcholinesterase iodide as substrate preincubated for 6 mins followed by substrate addition by Ellmans method	B	7.3	pIC50	50	nM	IC50	Eur J Med Chem (2013) 69: 632-646 [PMID:24095756]
ChEMBL	Inhibition of equine BCHE preincubated for 6 mins followed by addition of S-butyrylcholine iodide as substrate by Ellman's method	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2016) 24: 4324-4338 [PMID:27460699]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured at 1 min interval for 3 mins by Ellmans method	B	7.3	pIC50	50	nM	IC50	Bioorg Med Chem (2017) 25: 2387-2398 [PMID:28302511]
ChEMBL	Inhibition of equine serum BChE using butylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Ellman's method	B	7.33	pIC50	47	nM	IC50	Bioorg Med Chem (2013) 21: 7275-7282 [PMID:24148835]
ChEMBL	Inhibition of equine serum BuChE using s-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured up to 3 mins by Ellman's method	B	7.34	pIC50	46	nM	IC50	Eur J Med Chem (2016) 123: 282-297 [PMID:27484514]
ChEMBL	Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180 seconds by Ellman's method	B	7.38	pIC50	42	nM	IC50	Eur J Med Chem (2013) 64: 540-553 [PMID:23685572]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method	B	7.39	pIC50	41	nM	IC50	Eur J Med Chem (2011) 46: 5885-5893 [PMID:22019228]
ChEMBL	Inhibition of equine serum BuChE using butyrylcholine as substrate by Ellman's method	B	7.39	pIC50	41	nM	IC50	Bioorg Med Chem (2012) 20: 3038-3048 [PMID:22472046]
ChEMBL	Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 30 mins followed by substrate addition and measured after 30 mins by Ellman's method	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2019) 177: 198-211 [PMID:31136894]
ChEMBL	Inhibition of horse serum BuChE pre-incubated for 20 mins before butylthicoline iodide substrate addition by Ellman's assay	B	7.4	pIC50	40	nM	IC50	Bioorg Med Chem Lett (2015) 25: 807-810 [PMID:25597007]
ChEMBL	Inhibition of horse serum BuChE by Ellman's method	B	7.4	pIC50	40	nM	IC50	J Nat Prod (2006) 69: 1341-1346 [PMID:16989531]
ChEMBL	Inhibition of horse serum BChE using BTC as substrate preincubated for 15 mins followed by substrate addition by UV-spectrophotometric analysis	B	7.43	pIC50	37.08	nM	IC50	Eur J Med Chem (2016) 122: 17-26 [PMID:27343850]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine chloride as substrate by spectrophotometer analysis	B	7.43	pIC50	37	nM	IC50	Bioorg Med Chem (2014) 22: 3213-3219 [PMID:24794747]
ChEMBL	Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins before substrate addition by Ellman's method	B	7.45	pIC50	35.2	nM	IC50	Eur J Med Chem (2015) 93: 42-50 [PMID:25656088]
ChEMBL	Inhibition of horse serum butyrylcholinesterase using butylthiocholine as substrate incubated for 15 mins followed by substrate addition measured for 2 mins by Ellman's method	B	7.48	pIC50	33.4	nM	IC50	Eur J Med Chem (2013) 63: 299-312 [PMID:23501115]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins prior to substrate addition by Ellman's method	B	7.49	pIC50	32	nM	IC50	Eur J Med Chem (2013) 68: 291-300 [PMID:23988412]
ChEMBL	Inhibition of equine serum BuChE	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2020) 30: 127609-127609 [PMID:33039562]
ChEMBL	inhibition of equine serum BuChE by Ellman's method	B	7.52	pIC50	29.98	nM	IC50	Eur J Med Chem (2010) 45: 1415-1423 [PMID:20079560]
ChEMBL	Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	B	7.54	pIC50	29	nM	IC50	Bioorg Med Chem (2017) 25: 3997-4007 [PMID:28578994]
ChEMBL	Inhibition of equine serum BChE using butylthiocholine iodide as substrate incubated for 10 mins followed by substrate addition by Ellman's method	B	7.54	pIC50	29	nM	IC50	Bioorg Med Chem (2018) 26: 4716-4725 [PMID:30104121]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition by Ellman's method	B	7.54	pIC50	29	nM	IC50	Bioorg Med Chem (2017) 25: 5981-5994 [PMID:28986116]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every minute by Ellman's method	B	7.61	pIC50	24.27	nM	IC50	Eur J Med Chem (2018) 144: 128-136 [PMID:29268129]
ChEMBL	Inhibition of horse serum BChE using butyrylthiocholine chloride as substrate after 15 mins by Ellman's method	B	7.67	pIC50	21.6	nM	IC50	Eur J Med Chem (2013) 62: 745-753 [PMID:23454517]
ChEMBL	Inhibition of equine BuChE by Ellman's method	B	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2011) 21: 5881-5887 [PMID:21873056]
ChEMBL	Inhibition of equine serum BChE using acetylthiocholine chloride as substrate after 15 mins by Ellman's method	B	7.68	pIC50	21	nM	IC50	Eur J Med Chem (2011) 46: 4970-4979 [PMID:21871694]
ChEMBL	Inhibition of equine serum BChE after 15 mins incubation by spectrophotometry based Ellman's method	B	7.68	pIC50	21	nM	IC50	Bioorg Med Chem Lett (2012) 22: 2257-2261 [PMID:22341944]
ChEMBL	Inhibition of horse serum BuChE using S-butyrylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman method	B	7.69	pIC50	20.19	nM	IC50	Eur J Med Chem (2015) 95: 153-165 [PMID:25812965]
ChEMBL	Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition measured up to 180 secs by spectrophotometric-based Ellman's method	B	7.7	pIC50	20	nM	IC50	Bioorg Med Chem (2016) 24: 1528-1539 [PMID:26917219]
ChEMBL	Inhibition of horse serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman method	B	7.72	pIC50	19.2	nM	IC50	Bioorg Med Chem (2013) 21: 7406-7417 [PMID:24128814]
ChEMBL	Inhibition of equine serum BuChE	B	7.72	pIC50	19	nM	IC50	Bioorg Med Chem Lett (2010) 20: 3606-3609 [PMID:20472431]
ChEMBL	Inhibition of equine serum BuChE using S-butylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by Ellman's method	B	7.77	pIC50	17	nM	IC50	Eur J Med Chem (2017) 125: 853-864 [PMID:27744252]
ChEMBL	Inhibition of equine serum BuChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric analysis	B	7.8	pIC50	16	nM	IC50	Bioorg Med Chem (2017) 25: 2946-2955 [PMID:28454848]
ChEMBL	Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method	B	7.8	pIC50	15.8	nM	IC50	Bioorg Med Chem Lett (2013) 23: 6737-6742 [PMID:24220172]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method	B	7.8	pIC50	15.8	nM	IC50	Bioorg Med Chem (2012) 20: 5884-5892 [PMID:22944335]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine as substrate incubated for 5 mins followed by substrate addition and measured after 5 mins by spectrophotometric based Ellman's method	B	7.82	pIC50	15	nM	IC50	Eur J Med Chem (2021) 225: 113783-113783 [PMID:34461507]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method	B	7.82	pIC50	15	nM	IC50	J Med Chem (2013) 56: 9089-9099 [PMID:24160297]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate pre-incubated for 5 mins followed by substrate addition and measured after 5 mins by Ellman's method	B	7.82	pIC50	15	nM	IC50	Eur J Med Chem (2020) 187: 111916-111916 [PMID:31812794]
ChEMBL	Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method	B	7.82	pIC50	15	nM	IC50	Bioorg Med Chem (2014) 22: 1355-1361 [PMID:24461494]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine as substrate preincubated for 5 mins followed by substrate addition and measured after 5 mins by Ellman's method	B	7.82	pIC50	15	nM	IC50	Eur J Med Chem (2021) 218: 113397-113397 [PMID:33838585]
ChEMBL	Inhibition of equine serum BuChE using acetylthiocholine iodide as substrate after 8 mins by Ellman's method	B	7.82	pIC50	14.98	nM	IC50	Eur J Med Chem (2018) 145: 760-769 [PMID:29353726]
ChEMBL	Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 20 mins followed by substrate addition by Ellman's method	B	7.84	pIC50	14.45	nM	IC50	Eur J Med Chem (2016) 116: 200-209 [PMID:27061983]
ChEMBL	Inhibition of equine BuChE using ACTI as substrate preincubated for 29 mins followed by substrate addition measured at 1 min intervals for 10 mins by Ellman's assay	B	7.85	pIC50	14	nM	IC50	J Med Chem (2016) 59: 7683-7689 [PMID:27405689]
ChEMBL	Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine chloride as substrate preincubated for 15 mins before substrate addition by Ellman's method	B	7.85	pIC50	14	nM	IC50	Bioorg Med Chem (2012) 20: 2527-2534 [PMID:22444876]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine as substrate preincubated for 20 mins followed by substrate addition measured every 2 mins for 20 mins by Ellman's method	B	7.85	pIC50	14	nM	IC50	Eur J Med Chem (2017) 139: 367-377 [PMID:28810188]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 6 mins by Ellman's method	B	7.89	pIC50	13	nM	IC50	Eur J Med Chem (2017) 139: 280-289 [PMID:28803044]
ChEMBL	Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay	B	7.89	pIC50	13	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4462-4466 [PMID:22633691]
ChEMBL	Inhibition of equine serum BChE by Ellman's method	B	7.96	pIC50	11	nM	IC50	Eur J Med Chem (2011) 46: 1572-1581 [PMID:21367493]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate after 5 mins by Ellman's method	B	7.97	pIC50	10.6	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3162-3165 [PMID:23639542]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate pretreated followed by substrate addition and measured after 2 mins by Ellman's method	B	7.97	pIC50	10.6	nM	IC50	Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931]
ChEMBL	Inhibition of equine serum BuChE using BTCI as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by Ellman assay	B	8	pIC50	10	nM	IC50	J Med Chem (2016) 59: 5823-5846 [PMID:27253679]
ChEMBL	Inhibition of horse serum BuChE using butyrylthiocholine as substrate by UV spectroscopic analysis	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2014) 81: 350-358 [PMID:24858540]
ChEMBL	Inhibition of equine serum BuchE	B	8	pIC50	10	nM	IC50	Bioorg Med Chem Lett (2008) 18: 3790-3793 [PMID:18524585]
ChEMBL	Inhibition of equine serum BChE by Ellman's method	B	8	pIC50	10	nM	IC50	Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490]
ChEMBL	Inhibition of BuChE in horse serum by Ellman method	B	8	pIC50	10	nM	IC50	J Med Chem (2009) 52: 7249-7257 [PMID:19856923]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins by Ellman's method	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2017) 125: 1200-1212 [PMID:27863370]
ChEMBL	Inhibition of BuChE in horse serum using butyrylthiocholine as substrate by Ellman method	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2011) 46: 2224-2235 [PMID:21420206]
ChEMBL	Inhibition of horse serum BChE by Ellman's reaction	B	8	pIC50	10	nM	IC50	J Med Chem (2010) 53: 4927-4937 [PMID:20545360]
ChEMBL	Inhibition of equine serum BChE preincubated for 15 mins followed by addition of S-butyrylthiocholine iodide as substrate measured after 30 mins by Ellman's microplate assay	B	8	pIC50	10	nM	IC50	Bioorg Med Chem (2016) 24: 3742-3751 [PMID:27328658]
ChEMBL	Inhibition of equine serum BuChE by Ellman's method	B	8	pIC50	10	nM	IC50	Eur J Med Chem (2010) 45: 6152-6158 [PMID:20926162]
ChEMBL	Inhibition of horse serum BChE by Ellman's method	B	8	pIC50	10	nM	IC50	J Med Chem (2012) 55: 1303-1317 [PMID:22243648]
ChEMBL	Inhibition of horse serum BChE using acetylthiocholine iodide as substrate preincubated for 5 mins before substrate addition by Ellman's method	B	8.01	pIC50	9.8	nM	IC50	Bioorg Med Chem (2013) 21: 4928-4937 [PMID:23891231]
ChEMBL	Inhibition of equine serum BChE using (S)-butyrylthiocholine iodide as substrate measured for 6 mins by Ellman's method	B	8.1	pIC50	8	nM	IC50	J Nat Prod (2020) 83: 852-863 [PMID:32150413]
ChEMBL	Inhibition of equine serum BCHE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by DTNB addition for 5 mins and subsequent addition of substrate measured after 3 mins by Ellman's method	B	8.14	pIC50	7.2	nM	IC50	Eur J Med Chem (2018) 148: 238-254 [PMID:29466774]
ChEMBL	Inhibition of horse serum BChE by Ellman's method	B	8.16	pIC50	6.95	nM	IC50	Bioorg Med Chem (2010) 18: 1181-1193 [PMID:20061157]
ChEMBL	Inhibition of horse serum BChE using butyrylthiocholine iodide as substrate preincubated for 35 mins followed by enzyme addition measured after 3 mins by Ellman's method	B	8.16	pIC50	6.95	nM	IC50	Eur J Med Chem (2014) 81: 158-175 [PMID:24836068]
ChEMBL	Inhibition of equine serum BChE by Ellman's method	B	8.19	pIC50	6.4	nM	IC50	Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964]
ChEMBL	Inhibition of equine serum BChE by Ellman's method	B	8.19	pIC50	6.38	nM	IC50	Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964]
ChEMBL	Inhibition of Equus caballus BChE preincubated for 10 mins measured after 15 mins by Ellman's method	B	8.28	pIC50	5.2	nM	IC50	Eur J Med Chem (2011) 46: 4676-4681 [PMID:21715067]
ChEMBL	Inhibition of horse serum BChE using butrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured for 10 mins by modified Ellman's method	B	8.28	pIC50	5.2	nM	IC50	Bioorg Med Chem (2016) 24: 2352-2359 [PMID:27083471]
ChEMBL	Inhibition of horse serum BuChE by Ellman's method	B	8.28	pIC50	5.2	nM	IC50	Bioorg Med Chem (2011) 19: 122-133 [PMID:21163662]
ChEMBL	Inhibition of horse serum BChE after 15 mins by Ellman's method	B	8.28	pIC50	5.2	nM	IC50	Eur J Med Chem (2011) 46: 1-10 [PMID:21111515]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by Ellman's method	B	8.28	pIC50	5.2	nM	IC50	Eur J Med Chem (2011) 46: 6119-6130 [PMID:22000936]
ChEMBL	Inhibition of equine serum BuChE by Ellman's method	B	8.28	pIC50	5.2	nM	IC50	J Med Chem (2010) 53: 5129-5143 [PMID:20575555]
ChEMBL	Inhibition of horse serum butyrylcholinesterase preincubated with compound for 10 mins using butrylcholine iodide as substrate after 15 mins by spectrophotometric analysis	B	8.28	pIC50	5.2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2384-2388 [PMID:21411323]
ChEMBL	Inhibition of horse AChE by colorimetric Ellman assay	B	8.29	pIC50	5.13	nM	IC50	J Med Chem (2012) 55: 5231-5242 [PMID:22624880]
ChEMBL	Inhibition of BChE from equine serum by Ellman's method	B	8.29	pIC50	5.13	nM	IC50	J Med Chem (2010) 53: 2094-2103 [PMID:20158205]
ChEMBL	Inhibition of horse serum BuChE pre-incubated for 10 mins before addition of butyrylthiocholine iodide substrate and further incubated for 15 mins by Ellman's method	B	8.29	pIC50	5.07	nM	IC50	J Med Chem (2016) 59: 9967-9973 [PMID:27736061]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by DTNB-reagent based Ellman's method	B	8.3	pIC50	5	nM	IC50	J Med Chem (2021) 64: 6856-6876 [PMID:33973470]
ChEMBL	Inhibition of horse serum BChE	B	8.3	pIC50	5	nM	IC50	Eur J Med Chem (2017) 138: 774-806 [PMID:28734245]
ChEMBL	Inhibition of equine serum BChE by modified Ellman's method	B	8.3	pIC50	5	nM	IC50	J Med Chem (2010) 53: 3611-3617 [PMID:20361801]
ChEMBL	Inhibition of equine serum BChE by modified Ellman's method	B	8.3	pIC50	4.97	nM	IC50	J Med Chem (2010) 53: 3611-3617 [PMID:20361801]
ChEMBL	Inhibition of horse serum BChE preincubated for 5 mins by Ellman's method	B	8.31	pIC50	4.9	nM	IC50	Eur J Med Chem (2010) 45: 5602-5611 [PMID:20926161]
ChEMBL	Inhibition of equine serum BChE using ATC iodide substrate by Ellman's assay	B	8.33	pIC50	4.7	nM	IC50	Bioorg Med Chem (2015) 23: 5610-5618 [PMID:26242241]
ChEMBL	Inhibition of BChE in equine serum using butyrylthiocholine iodide substrate by Ellman assay	B	8.36	pIC50	4.4	nM	IC50	J Med Chem (2015) 58: 6710-6715 [PMID:26278660]
ChEMBL	Inhibition of BChE in horse serum using butyrylthiocholine iodide as substrate after 120 mins by Ellman's method	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem (2014) 22: 3341-3350 [PMID:24835788]
ChEMBL	Inhibition of equine serum BuChE by Ellman's method	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem Lett (2021) 49: 128316-128316 [PMID:34391893]
ChEMBL	Inhibition of horse serum BChE by spectrophotometry based Ellman's method	B	8.4	pIC50	4	nM	IC50	Bioorg Med Chem (2014) 22: 3838-3849 [PMID:25017625]
ChEMBL	Inhibition of horse serum butyrylcholine esterase in presence of acetylcholine substrate by chemiluminescent assay	B	8.4	pIC50	4	nM	IC50	Eur J Med Chem (2008) 43: 657-661 [PMID:17624631]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine chloride substrate incubated for 5 mins before substrate addition measured at 3 min interval by Ellman method	B	8.42	pIC50	3.8	nM	IC50	Bioorg Med Chem (2012) 20: 6513-6522 [PMID:23000296]
ChEMBL	Inhibition of equine serum butyrylcholine esterase using butyrylcholine chloride as substrate incubated for 5 mins prior to substrate addition measured every 3 mins by Ellman's assay	B	8.42	pIC50	3.8	nM	IC50	J Med Chem (2012) 55: 3588-3592 [PMID:22420827]
ChEMBL	Inhibition of equine serum BChE	B	8.43	pIC50	3.7	nM	IC50	Bioorg Med Chem (2014) 22: 4867-4881 [PMID:25047936]
ChEMBL	Inhibition of equine serum BChE	B	8.44	pIC50	3.66	nM	IC50	Bioorg Med Chem (2014) 22: 4867-4881 [PMID:25047936]
ChEMBL	Inhibition of BuChE in equine serum using butyrylthiocholine iodide as substrate preincubated with enzyme for 10 mins prior to substrate challenge measured after 15 mins by Ellman's method	B	8.48	pIC50	3.3	nM	IC50	Bioorg Med Chem (2014) 22: 2496-2507 [PMID:24657052]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every minute for 10 mins by Ellman's method	B	8.49	pIC50	3.2	nM	IC50	Eur J Med Chem (2018) 145: 165-190 [PMID:29324339]
ChEMBL	Inhibition of horse AChE by colorimetric Ellman assay	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2012) 55: 5231-5242 [PMID:22624880]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every minute for 10 mins by Ellman's spectrophotometric method	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2017) 60: 5909-5926 [PMID:28613859]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate pretreated for 4.5 mins followed by substrate addition and measured after 2.5 mins by Ellman's method	B	8.57	pIC50	2.69	nM	IC50	Medchemcomm (2017) 8: 1346-1359 [PMID:30108847]
ChEMBL	Inhibition of equine BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins before substrate addition measured for 10 mins by Ellman's method	B	8.61	pIC50	2.43	nM	IC50	Medchemcomm (2012) 3: 627-634
ChEMBL	Inhibition of equine serum BuChE using BTC as substrate preincubated with enzyme for 5 mins followed by substrate addition for 5 mins by Ellman's method	B	8.7	pIC50	2	nM	IC50	Eur J Med Chem (2021) 225: 113792-113792 [PMID:34530376]
ChEMBL	Inhibition of BuChE in horse serum pre-incubated for 5 mins before addition of butyrylthiocholine iodide substrate by Ellman's assay	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem (2015) 23: 1629-1637 [PMID:25707322]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine chloride as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellmans method	B	8.7	pIC50	2	nM	IC50	Bioorg Med Chem Lett (2016) 26: 4140-4145 [PMID:27445168]
ChEMBL	Inhibition of equine serum BuChE after 5 mins by Ellman's method	B	8.7	pIC50	2	nM	IC50	Eur J Med Chem (2015) 92: 738-749 [PMID:25621991]
ChEMBL	Inhibition of equine serum BuChE preincubated for 5 mins followed by butyrylthiocholine iodide substrate addition measured after 5 mins by Ellman's method	B	8.7	pIC50	2	nM	IC50	Eur J Med Chem (2016) 124: 63-81 [PMID:27560283]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method	B	8.7	pIC50	2	nM	IC50	Eur J Med Chem (2017) 125: 676-695 [PMID:27721153]
ChEMBL	Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins prior to substrate addition measured after 5 mins by Ellman's method	B	8.82	pIC50	1.53	nM	IC50	Eur J Med Chem (2020) 185: 111785-111785 [PMID:31669851]
ChEMBL	Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate incubated for 15 mins followed by substrate addition by Ellman's method	B	8.92	pIC50	1.2	nM	IC50	Eur J Med Chem (2016) 122: 326-338 [PMID:27376495]
ChEMBL	Inhibition of horse serum BuChE using butyrylthiocholine as substrate pretreated for 10 mins followed by substrate addition measured after 15 mins by spectrophotometry based Ellman method	B	10.3	pIC50	0.05	nM	IC50	Eur J Med Chem (2017) 126: 576-589 [PMID:27918993]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078]
ChEMBL	Inhibition of human recombinant CDK5/p25 using histone H1 as substrate in presence of [gamma-33P]ATP incubated for 30 mins by liquid scintillation counting assay	B	5	pIC50	>10000	nM	IC50	Eur J Med Chem (2019) 168: 58-77 [PMID:30798053]
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635]
ChEMBL	DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	6.52	pIC50	300	nM	IC50	DrugMatrix in vitro pharmacology data
DAT/Dopamine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL338] [GtoPdb: 927] [UniProtKB: P23977]
ChEMBL	Inhibition of the reuptake of dopamine in rat corpora striata.	F	4.66	pIC50	22000	nM	IC50	J Med Chem (1989) 32: 1805-1813 [PMID:2754707]
GluN1/GluN2A/Glutamate NMDA receptor; GRIN1/GRIN2A in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907604] [GtoPdb: 455, 456] [UniProtKB: Q05586, Q12879]
ChEMBL	Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as relative inhibition of glycine/glutamate-induced current measured at +40 mV holding potential by whole-cell patch clamp method	B	4.07	pIC50	84600	nM	IC50	Eur J Med Chem (2021) 219: 113434-113434 [PMID:33892271]
ChEMBL	Inhibition of human GluN1a/GluN2A receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV holding potential by whole-cell patch clamp method	B	5.04	pIC50	9100	nM	IC50	Eur J Med Chem (2021) 219: 113434-113434 [PMID:33892271]
ChEMBL	Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assessed as LDH release after 30 mins	B	5.31	pIC50	4900	nM	IC50	J Med Chem (2010) 53: 3611-3617 [PMID:20361801]
ChEMBL	Inhibition of human NR1-1a/NR2A expressed in mouse L12-G10 cells assessed as inhibition of glutamate-induced excitotoxicity incubated for 16 hrs by LDH release assay	B	5.31	pIC50	4900	nM	IC50	J Med Chem (2015) 58: 6710-6715 [PMID:26278660]
GluN1/GluN2B/Glutamate NMDA receptor; GRIN1/GRIN2B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907603] [GtoPdb: 455, 457] [UniProtKB: Q05586, Q13224]
ChEMBL	Inhibition of dexamethasone-induced human NR1-1a/NR2B receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L13-E6 cells assessed as LDH release after 30 mins	B	4.36	pIC50	44000	nM	IC50	J Med Chem (2010) 53: 3611-3617 [PMID:20361801]
ChEMBL	Inhibition of human NR1-1a/NR2B expressed in mouse L13-E6 cells assessed as inhibition of glutamate-induced excitotoxicity incubated for 16 hrs by LDH release assay	B	4.36	pIC50	44000	nM	IC50	J Med Chem (2015) 58: 6710-6715 [PMID:26278660]
glycogen synthase kinase 3 beta/Glycogen synthase kinase-3 beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL262] [GtoPdb: 2030] [UniProtKB: P49841]
ChEMBL	Inhibition of human recombinant GSK-3beta using prephosphorylated polypeptide as substrate incubated for 30 mins in presence of ATP by Kinase-Glo luminescence assay	B	4	pIC50	>100000	nM	IC50	J Med Chem (2021) 64: 7483-7506 [PMID:34024109]
ChEMBL	Inhibition of recombinant human N-terminal His6-tagged GSK3beta H350L mutant expressed in baculovirus infected Sf21 cells using prephosphorylated polypeptide as substrate incubated for 1 min followed by substrate addition and measured after 30 mins by Kinase-Glo luminescence assay	B	6	pIC50	>1000	nM	IC50	Bioorg Med Chem (2021) 30: 115940-115940 [PMID:33340937]
ChEMBL	Inhibition of recombinant human N-terminal His6-tagged GSK-3beta H350L mutant expressed in baculovirus infected Sf21 cells using GSM as substrate incubated for 30 mins in presence of ATP by kinase-glo luminescence assay	B	6	pIC50	>1000	nM	IC50	Eur J Med Chem (2020) 207: 112751-112751 [PMID:32950908]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of hERG expressed in CHO-K1 cells assessed as reduction in thallium influx incubated for 30 minutes by FLIPR	B	4.84	pIC50	14312	nM	IC50	Eur J Med Chem (2021) 226: 113827-113827 [PMID:34530383]
Histamine N-methyltransferase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3241] [UniProtKB: Q01984]
ChEMBL	Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methyl-histamine	B	6.96	pIC50	110	nM	IC50	J Med Chem (2002) 45: 1128-1141 [PMID:11855993]
Monoamine oxidase A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3358] [UniProtKB: P21396]
ChEMBL	Inhibition Assay: The inhibitory activity of monoamine oxidases A and B was assessed by the Fowler and Tipton radiometric method (Biochem Pharmacol 1981, 30, 3329) using a purification of rat liver mitochondria as the source of enzymes. The inhibitory activity of MAO-B was compared to 25 ul of [14C]-phenylethylamine (PEA), 20 uM of activity, 2.5 mCi/mmol. The inhibitory activity of MAO-A was compared to 25 ul of [14C]-(5-hydroxytriptamine) (5-HT), 100 uM of activity, 0.5 mCi/mmol. Inhibition curves were performed in triplicate by incubating at least nine inhibitor concentrations for 30 min. A triplicate sample without inhibitor was always present so as to be aware of 100% of the MAO activity. The reaction took place with the addition of the substrate in a final volume of 225 ul of 50 mM phosphate buffer, pH 7.4, containing 20 ul of rat liver mitochondria at a concentration of 5 mg/ml. The reaction was carried out under continuous stirring at 37 C. for 4 minutes.	B	4.39	pIC50	40300	nM	IC50	US-8999994-B2. Derivatives of propargylamine having neuroprotective capacity for the treatment of Alzheimer's and Parkinson's diseases (2015)
ChEMBL	Inhibition of mitochondrial MAO-A in rat liver homogenates using [14C]-(5-hydroxy-triptamine) as substrate preincubated for 30 mins by liquid scintillation counting	B	7.4	pIC50	40	nM	IC50	Eur J Med Chem (2012) 52: 251-262 [PMID:22503231]
Monoamine oxidase B in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2993] [GtoPdb: 2490] [UniProtKB: P19643]
ChEMBL	Inhibition of mitochondrial MAO-B in rat liver homogenates using [14C]-phenylethylamine as substrate preincubated for 30 mins by liquid scintillation counting	B	7	pIC50	>100	nM	IC50	Eur J Med Chem (2012) 52: 251-262 [PMID:22503231]
M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229]
ChEMBL	Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells in ternary complex by EATCM analysis	B	5.18	pKd	5.18	-	logKd	J Med Chem (2010) 53: 2094-2103 [PMID:20158205]
ChEMBL	Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHO cells in binary complex by EATCM analysis	B	5.86	pKd	5.86	-	logKd	J Med Chem (2010) 53: 2094-2103 [PMID:20158205]
ChEMBL	Antagonist activity at human M1 mAChR expressed in CHO cells assessed as inhibition of oxotremorine M-stimulated calcium influx preincubated for 10 mins followed by oxotremorine M addition by Fluo-4 NW dye based fluorescence assay	F	4.89	pIC50	13000	nM	IC50	Eur J Med Chem (2018) 150: 292-306 [PMID:29533874]
M1 receptor/Muscarinic acetylcholine receptor M1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3733] [GtoPdb: 13] [UniProtKB: P12657]
ChEMBL	Binding affinity against mouse Muscarinic acetylcholine receptor M1 using cerebral cortex and [3H]pirenzepine	B	5.7	pIC50	2000	nM	IC50	J Med Chem (1992) 35: 3141-3147 [PMID:1507203]
ChEMBL	Compound was evaluated for the competitive inhibition of [3H]pirenzepine binding to Muscarinic acetylcholine receptor M1 of mouse cerebral cortex	B	5.7	pIC50	2000	nM	IC50	J Med Chem (1992) 35: 1102-1108 [PMID:1552502]
GtoPdb	-	-	5.7	pIC50	2000	nM	IC50	J Med Chem (1992) 35: 1102-8 [PMID:1552502]
M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172]
ChEMBL	Binding affinity against mouse Muscarinic acetylcholine receptor M2 using heart tissue and [3H]N-methylscopolamine	F	5.24	pKi	5800	nM	Ki	J Med Chem (1992) 35: 3141-3147 [PMID:1507203]
Muscarinic acetylcholine receptor M2 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4781] [UniProtKB: P06199]
ChEMBL	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	B	5.2	pEC50	6309.57	nM	EC50	J Med Chem (2007) 50: 5685-5695 [PMID:17944454]
ChEMBL	Inhibition of [3H]NMS dissociation from porcine muscarinic M2 receptor	B	5.2	pEC50	6300	nM	EC50	J Med Chem (2007) 50: 5685-5695 [PMID:17944454]
M2 receptor/Muscarinic acetylcholine receptor M2 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3197] [GtoPdb: 14] [UniProtKB: Q9ERZ4]
ChEMBL	Ability to displace [3H]oxotremorine ([3H]-OXO-M) from mouse cerebral cortex	B	6.66	pKi	220	nM	Ki	J Med Chem (1992) 35: 3141-3147 [PMID:1507203]
ChEMBL	Compound was evaluated for the competitive inhibition of [3H]methylscopolamine binding to Muscarinic acetylcholine receptor M2 of mouse cerebral cortex	B	5.68	pIC50	2100	nM	IC50	J Med Chem (1992) 35: 1102-1108 [PMID:1552502]
GtoPdb	-	-	5.68	pIC50	2100	nM	IC50	J Med Chem (1992) 35: 1102-8 [PMID:1552502]
M2 receptor/Muscarinic acetylcholine receptor M2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL309] [GtoPdb: 14] [UniProtKB: P10980]
ChEMBL	Binding affinity against mouse M2 muscarinic receptor using heart tissue and [3H]N-methylscopolamine	B	5.68	pIC50	2100	nM	IC50	J Med Chem (1992) 35: 3141-3147 [PMID:1507203]
nicotinic acetylcholine receptor α3 subunit/nicotinic acetylcholine receptor β4 subunit/nicotinic acetylcholine receptor α6 subunit/Nicotinic acetylcholine receptor alpha6/alpha3/beta4 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3137276] [GtoPdb: 464, 474, 467] [UniProtKB: P04757, P12392, P43143]
ChEMBL	Inhibition of human GluN1a/GluN2B receptor expressed in HEK293 cells assessed as inhibition of glycine/glutamate-induced current measured at -60 mV holding potential by whole-cell patch clamp method	B	4.71	pIC50	19700	nM	IC50	Eur J Med Chem (2021) 219: 113434-113434 [PMID:33892271]
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975]
ChEMBL	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)	B	6.29	pKi	513	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparation	F	4.96	pIC50	11000	nM	IC50	J Med Chem (1996) 39: 570-581 [PMID:8558529]
ChEMBL	DRUGMATRIX: Norepinephrine Transporter radioligand binding (ligand: [125I] RTI-55)	B	6.29	pIC50	517	nM	IC50	DrugMatrix in vitro pharmacology data
Norepinephrine transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL304] [UniProtKB: Q9WTR4]
ChEMBL	Inhibition of norepinephrine reuptake in rat whole brains minus cerebellar	F	4.96	pIC50	11000	nM	IC50	J Med Chem (1989) 32: 1805-1813 [PMID:2754707]
ChEMBL	Inhibition of neuronal uptake of Noradrenaline in rat brain homogenate	F	5.1	pIC50	7900	nM	IC50	J Med Chem (1997) 40: 3516-3523 [PMID:9357518]
Plasmodium falciparum 3D7 (target type: ORGANISM) [ChEMBL: CHEMBL2366922]
ChEMBL	Antimalarial activity against chloroquine-sensitive ring-stage Plasmodium falciparum 3D7 assessed as parasite viability after 72 hrs by malstat assay	F	4.9	pIC50	12500	nM	IC50	Bioorg Med Chem (2016) 24: 3636-3642 [PMID:27316542]
SERT/Serotonin transporter in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL313] [GtoPdb: 928] [UniProtKB: P31652]
ChEMBL	Inhibition of serotonin reuptake in rat whole brains without cerebellum	F	4.72	pIC50	19000	nM	IC50	J Med Chem (1989) 32: 1805-1813 [PMID:2754707]
ChEMBL	Inhibition of neuronal uptake of 5 - Hydroxytryptamine in rat brain homogenate	F	5.12	pIC50	7600	nM	IC50	J Med Chem (1997) 40: 3516-3523 [PMID:9357518]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay	B	4.66	pIC50	21720	nM	IC50	J Med Chem (2017) 60: 2685-2696 [PMID:28230985]
Cav2.1/Cav3.1/Cav1.4/Cav3.2/Cav2.2/Cav1.3/Cav1.1/Cav1.2/Cav2.3/Cav3.3/Voltage-gated calcium channel in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2363032] [GtoPdb: 532, 535, 531, 536, 533, 530, 528, 529, 534, 537] [UniProtKB: O00305, O00555, O43497, O60359, O60840, O95180, P54284, P54289, P62955, Q00975, Q01668, Q02641, Q06432, Q08289, Q13698, Q13936, Q15878, Q7Z3S7, Q8IZS8, Q8WXS5, Q9BXT2, Q9NY47, Q9P0X4, Q9UBN1, Q9UF02, Q9Y698]
ChEMBL	Inhibition of VGCC (unknown origin)	B	4.77	pIC50	17000	nM	IC50	Eur J Med Chem (2019) 166: 381-389 [PMID:30739821]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]