galantamine [Ligand Id: 6693] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL659 (Acumor xl, Consion xl, Elmino xl, (-)-galantamine, Galantamine, (-)-galanthamine, Galanthamine, Galsya xl, Galzemic xl, Gatalin xl, Gazylan xl, Lotprosin xl, Luventa xl, NSC-100058, Razadyne, Reminyl, Reminyl xl, Zeebral xl) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
| ChEMBL | Inhibition of Torpedo californica AChE | B | 6.19 | pIC50 | 652 | nM | IC50 | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
| ChEMBL | Inhibition of Torpedo californica AchE activity by Ellman's assay | B | 6.23 | pIC50 | 590 | nM | IC50 | Bioorg Med Chem (2008) 16: 6560-6567 [PMID:18538575] |
| ChEMBL | Inhibition of AChE | B | 6.26 | pIC50 | 550 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2123-2125 [PMID:17317172] |
| ChEMBL | Inhibitory activity against acetylcholinesterase (AChE) from Torpedo californica (Reversible type of inhibition) | B | 6.44 | pIC50 | 360 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 1825-1827 [PMID:12729674] |
| Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275] | ||||||||
| ChEMBL | Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry | B | 5.81 | pKi | 1560 | nM | Ki | J Med Chem (2005) 48: 8270-8288 [PMID:16366609] |
| ChEMBL | Competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot method | B | 5.97 | pKi | 1060 | nM | Ki | J Med Chem (2013) 56: 2038-2044 [PMID:23330848] |
| ChEMBL | Inhibitory activity against AChE from electric eel | B | 6.36 | pKi | 440 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 573-580 [PMID:16274989] |
| ChEMBL | Competitive inhibition of Electrophorus electricus AChE by Lineweaver-Burke plot analysis | B | 6.37 | pKi | 428 | nM | Ki | Bioorg Med Chem (2010) 18: 5861-5872 [PMID:20656495] |
| ChEMBL | In vitro inhibitory activity against acetylcholinesterase (AChE) in Electrophorus electricus | B | 4.46 | pIC50 | 35000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2389-2391 [PMID:12824041] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured every 5 mins for 15 mins by spectrophotometric method | B | 4.66 | pIC50 | 21820 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 2481-2484 [PMID:29887354] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured every 15 secs for 5 to 10 mins by Ellman's method | B | 4.9 | pIC50 | 12730 | nM | IC50 | Bioorg Med Chem (2016) 24: 5762-5770 [PMID:27681239] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 4.98 | pIC50 | 10530 | nM | IC50 | Eur J Med Chem (2014) 76: 376-386 [PMID:24594525] |
| ChEMBL | Inhibition of electric eel AChE using ATC as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's assay | B | 5.07 | pIC50 | 8500 | nM | IC50 | Bioorg Med Chem (2016) 24: 886-893 [PMID:26795115] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric method | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3368-3376 [PMID:28457693] |
| ChEMBL | Competitive inhibition of Electrophorus electricus AChE using acetylcholine as substrate by Lineweaver-Burk plot method | B | 5.13 | pIC50 | 7440 | nM | IC50 | J Med Chem (2013) 56: 2038-2044 [PMID:23330848] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate by Ellman's method | B | 5.35 | pIC50 | 4480 | nM | IC50 | Eur J Med Chem (2016) 124: 270-283 [PMID:27592396] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine as substrate assessed as concentration of 5-thio-2-nitrobenzoic acid ion formed by spectrophotometric/Ellman's method | B | 5.4 | pIC50 | 4000 | nM | IC50 | J Nat Prod (2015) 78: 1189-1192 [PMID:26030662] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine as substrate after 10 mins by Ellman's method | B | 5.4 | pIC50 | 4000 | nM | IC50 | Bioorg Med Chem (2013) 21: 1735-1748 [PMID:23462716] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 5.45 | pIC50 | 3580 | nM | IC50 | Eur J Med Chem (2019) 179: 680-693 [PMID:31280020] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate by Ellman's method | B | 5.45 | pIC50 | 3570 | nM | IC50 | Eur J Med Chem (2017) 127: 671-690 [PMID:27823887] |
| ChEMBL | Inhibition of electric eel AChE preincubated for 6 mins followed by addition of acetylthiocholine iodide by Ellman's method | B | 5.45 | pIC50 | 3560 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3881-3885 [PMID:27426301] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem (2010) 18: 5071-5080 [PMID:20580236] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's assay | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Nat Prod (2006) 69: 1341-1346 [PMID:16989531] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6185-6187 [PMID:20850311] |
| ChEMBL | Inhibition of eel AChE | B | 5.5 | pIC50 | 3180 | nM | IC50 | Bioorg Med Chem (2007) 15: 1034-1043 [PMID:17085051] |
| ChEMBL | Inhibition of electric eel AChE preincubated for 5 mins followed by addition of acetylthiocholine iodide as substrate measured after 2 mins by Ellman's method | B | 5.51 | pIC50 | 3120 | nM | IC50 | Eur J Med Chem (2016) 119: 260-277 [PMID:27227482] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | B | 5.55 | pIC50 | 2800 | nM | IC50 | Eur J Med Chem (2017) 137: 280-291 [PMID:28605675] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | B | 5.56 | pIC50 | 2770 | nM | IC50 | Medchemcomm (2014) 5: 609-616 |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as a substrate measured for 125 secs by DNTB reagent based Ellman's method | B | 5.57 | pIC50 | 2700 | nM | IC50 | ACS Med Chem Lett (2021) 12: 1718-1725 [PMID:34795859] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2636-2641 [PMID:23511019] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate incubated for 6 mins by spectrophotometric method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Bioorg Med Chem (2014) 22: 6089-6104 [PMID:25282654] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition by Ellman's method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 2368-2373 [PMID:24726809] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition by Ellmans method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Eur J Med Chem (2013) 69: 632-646 [PMID:24095756] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180 seconds by Ellman's method | B | 5.57 | pIC50 | 2670 | nM | IC50 | Eur J Med Chem (2013) 64: 540-553 [PMID:23685572] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.62 | pIC50 | 2410 | nM | IC50 | Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.62 | pIC50 | 2410 | nM | IC50 | Eur J Med Chem (2015) 102: 80-92 [PMID:26244990] |
| ChEMBL | Inhibition of Electric eel AChE assessed as amount of thiocholine released using acetylthiocholine iodide as substrate after 6 mins by Ellman's method | B | 5.62 | pIC50 | 2400 | nM | IC50 | J Nat Prod (2014) 77: 650-656 [PMID:24521095] |
| ChEMBL | Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry | B | 5.66 | pIC50 | 2200 | nM | IC50 | J Med Chem (2005) 48: 8270-8288 [PMID:16366609] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by Ellman's microplate assay | B | 5.68 | pIC50 | 2090 | nM | IC50 | Eur J Med Chem (2013) 67: 221-229 [PMID:23871902] |
| ChEMBL | Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2014) 22: 906-916 [PMID:24369842] |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2013) 21: 3022-3031 [PMID:23602518] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2019) 27: 2621-2628 [PMID:30952387] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins by spectrophotometer analysis | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1815-1819 [PMID:24594354] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.69 | pIC50 | 2050 | nM | IC50 | Bioorg Med Chem (2017) 25: 1352-1363 [PMID:28089589] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Nat Prod (2010) 73: 1632-1635 [PMID:20828184] |
| ChEMBL | Inhibition of electric eel acetylcholinesterase | B | 5.74 | pIC50 | 1820 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2263-2266 [PMID:18356045] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by Ellman's method | B | 5.77 | pIC50 | 1700 | nM | IC50 | Bioorg Med Chem (2018) 26: 4952-4962 [PMID:30190181] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured for 45 mins by Ellmans microplate assay | B | 5.78 | pIC50 | 1670 | nM | IC50 | Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5.84 | pIC50 | 1450 | nM | IC50 | Eur J Med Chem (2018) 143: 1301-1311 [PMID:29126732] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate after 15 mins by Ellman's method | B | 5.84 | pIC50 | 1450 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2880-2882 [PMID:23583510] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.89 | pIC50 | 1280 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1325-1329 [PMID:30956012] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate measured every minute for fifteen minutes by Ellman's method | B | 5.99 | pIC50 | 1020 | nM | IC50 | Eur J Med Chem (2017) 127: 771-780 [PMID:27823880] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 6.18 | pIC50 | 665 | nM | IC50 | Eur J Med Chem (2016) 107: 219-232 [PMID:26588065] |
| ChEMBL | Inhibition of electric eel AChE | B | 6.19 | pIC50 | 640 | nM | IC50 | J Med Chem (2006) 49: 5411-5413 [PMID:16942014] |
| ChEMBL | Inhibition of Electric eel AChE after 2 mins by colorimetric Ellman assay | B | 6.19 | pIC50 | 640 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2946-2949 [PMID:20350808] |
| ChEMBL | Inhibition of electric eel AChE type 6S by Ellman's assay | B | 6.19 | pIC50 | 640 | nM | IC50 | Bioorg Med Chem (2008) 16: 4252-4261 [PMID:18343673] |
| ChEMBL | Inhibition of electric eel AChE by colorimetric Ellman's assay | B | 6.19 | pIC50 | 640 | nM | IC50 | Eur J Med Chem (2011) 46: 3118-3123 [PMID:21546135] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 6.19 | pIC50 | 640 | nM | IC50 | Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964] |
| ChEMBL | Inhibition of electric eel AChE by modified Ellman's method | B | 6.2 | pIC50 | 636 | nM | IC50 | J Med Chem (2010) 53: 3611-3617 [PMID:20361801] |
| ChEMBL | Inhibition of electric eel AChE by modified Ellman's method | B | 6.2 | pIC50 | 635.33 | nM | IC50 | J Med Chem (2010) 53: 3611-3617 [PMID:20361801] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 6.2 | pIC50 | 635.33 | nM | IC50 | Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964] |
| ChEMBL | Inhibition of Electric eel AChE after 2 mins by colorimetric Ellman assay | B | 6.2 | pIC50 | 635.33 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2946-2949 [PMID:20350808] |
| ChEMBL | Inhibition of electric eel AChE | B | 6.2 | pIC50 | 635.33 | nM | IC50 | J Med Chem (2006) 49: 5411-5413 [PMID:16942014] |
| ChEMBL | Inhibition of electric eel AChE type 6S by Ellman's assay | B | 6.2 | pIC50 | 635.33 | nM | IC50 | Bioorg Med Chem (2008) 16: 4252-4261 [PMID:18343673] |
| ChEMBL | Inhibition of electric eel acetylcholine esterase using acetylcholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4462-4466 [PMID:22633691] |
| ChEMBL | Inhibition of electric eel AChE by modified Ellman method | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2010) 18: 1244-1251 [PMID:20056426] |
| ChEMBL | Inhibition of electric eel Acetylcholinesterase | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2011) 19: 2298-2305 [PMID:21397508] |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine chloride as substrate preincubated for 15 mins by Ellman's method | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2011) 19: 7228-7235 [PMID:22041172] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric analysis | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2017) 25: 2946-2955 [PMID:28454848] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's assay | B | 6.21 | pIC50 | 623 | nM | IC50 | Bioorg Med Chem (2010) 18: 4475-4484 [PMID:20471843] |
| ChEMBL | Inhibition of Electrophorus electricus AChE using acetylthiocholine iodide as substrate incubated for 15 mins followed by substrate addition by Ellman's method | B | 6.21 | pIC50 | 610 | nM | IC50 | Eur J Med Chem (2016) 122: 326-338 [PMID:27376495] |
| ChEMBL | Inhibition of electric eel AChE using acetylcholine iodide as substrate measured every 5 sec for 2 mins by Ellman's method | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2885-2888 [PMID:22425563] |
| ChEMBL | Inhibition of electric eel AChE pretreated for 20 mins followed by acetylthiocholine iodide substrate addition measured for 5 mins by Ellman's method | B | 6.25 | pIC50 | 560 | nM | IC50 | Eur J Med Chem (2017) 125: 288-298 [PMID:27688184] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 6.25 | pIC50 | 560 | nM | IC50 | J Med Chem (2010) 53: 5129-5143 [PMID:20575555] |
| ChEMBL | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition and measured upto 5 mins by Ellman's method | B | 6.25 | pIC50 | 560 | nM | IC50 | Eur J Med Chem (2019) 177: 414-424 [PMID:31158754] |
| ChEMBL | Inhibition of electric eel AChE | B | 6.26 | pIC50 | 550 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3765-3768 [PMID:17451950] |
| ChEMBL | Inhibition of electric eel AChE by Ellman's method | B | 6.26 | pIC50 | 550 | nM | IC50 | Eur J Med Chem (2009) 44: 2523-2532 [PMID:19243862] |
| ChEMBL | Inhibitory activity against AChE from electric eel | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 573-580 [PMID:16274989] |
| ChEMBL | Inhibition of Electrophorus electricus (electric eel) acetylcholinesterase (AChE) using acetylthiocholine iodide as substrate preincubated for 15 min | B | 6.3 | pIC50 | 500 | nM | IC50 | Med Chem Res (2012) 21: 2329-2339 |
| ChEMBL | Inhibition of electric eel AChE using ATCI as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by DTNB-based spectrophotometric analysis | B | 6.32 | pIC50 | 480 | nM | IC50 | J Nat Prod (2016) 79: 1241-1248 [PMID:27096334] |
| ChEMBL | Inhibition of Electrophorus electricus AChE by Ellman's method | B | 6.44 | pIC50 | 360 | nM | IC50 | J Med Chem (2007) 50: 5311-5323 [PMID:17902635] |
| ChEMBL | Compound was assessed for in vitro inhibition of Acetylcholinesterase isolated from Electrophorus electricus | B | 6.44 | pIC50 | 360 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 637-639 [PMID:10762042] |
| ChEMBL | Inhibition of electric eel AChE | B | 6.6 | pIC50 | 250 | nM | IC50 | Eur J Med Chem (2017) 136: 294-304 [PMID:28505534] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] | ||||||||
| ChEMBL | Inhibition of AChE by Ellman's assay | B | 6.52 | pKi | 300 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 5290-5294 [PMID:20655219] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) assessed as AChI hydrolysis using AChI and DTNB as substrate by Ellman's method | B | 6.6 | pKi | 250 | nM | Ki | Bioorg Med Chem (2015) 23: 3592-3602 [PMID:25921269] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine as substrate | B | 7.21 | pKi | 61.96 | nM | Ki | Bioorg Med Chem (2012) 20: 6739-6750 [PMID:23041347] |
| ChEMBL | Inhibition of human AChE assessed as acetylthiocholine hydrolysis | B | 7.21 | pKi | 61.9 | nM | Ki | Bioorg Med Chem (2014) 22: 4784-4791 [PMID:25088549] |
| ChEMBL | Inhibition of human acetylcholinesterase using ATCI/DTNB as substrate preincubated for 30 mins followed by substrate addition measured for 60 mins by Ellman method | B | 4.05 | pIC50 | 90000 | nM | IC50 | Bioorg Med Chem (2015) 23: 4567-4575 [PMID:26105711] |
| ChEMBL | Inhibition of AChE by spectrophotometry | B | 4.13 | pIC50 | 73900 | nM | IC50 | J Nat Prod (2009) 72: 500-502 [PMID:19215141] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by Ellman's method | B | 4.77 | pIC50 | 17100 | nM | IC50 | RSC Med Chem (2020) 11: 307-316 [PMID:33479638] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate pretreated for 15 mins followed by substrate addition and measured by DTNB reagent based assay | B | 4.86 | pIC50 | 13900 | nM | IC50 | J Nat Prod (2018) 81: 1693-1700 [PMID:30040425] |
| ChEMBL | Inhibition of human erythrocytes BChE | B | 5.14 | pIC50 | 7300 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibition of human plasma BChE | B | 5.14 | pIC50 | 7300 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) | B | 5.19 | pIC50 | 6400 | nM | IC50 | Bioorg Med Chem (2020) 28: 115820-115820 [PMID:33120080] |
| ChEMBL | Inhibition of human acetylcholinesterase | B | 5.42 | pIC50 | 3800 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate after 5 mins by DTNB method | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4707-4712 [PMID:22704921] |
| ChEMBL | Inhibition of AChE by microplate assay | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Med Chem (2004) 47: 6248-6254 [PMID:15566295] |
| ChEMBL | Inhibition of AChE (unknown origin) using 2-nitrobenzoate-5-mercaptothiocholine as substrate after 15 to 60 mins by microplate assay | B | 5.49 | pIC50 | 3200 | nM | IC50 | Bioorg Med Chem (2014) 22: 1262-1267 [PMID:24485122] |
| ChEMBL | Inhibition of AChE in human erythrocytes using acetylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition measured for 15 mins by Ellman's method | B | 5.52 | pIC50 | 3030 | nM | IC50 | Eur J Med Chem (2019) 179: 404-422 [PMID:31265934] |
| ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine as substrate measured after 5 mins by Ellman's method | B | 5.52 | pIC50 | 3000 | nM | IC50 | Eur J Med Chem (2020) 191: 112140-112140 [PMID:32088494] |
| ChEMBL | Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate incubated for 25 mins by DTNB reagent based Ellman's method | B | 5.54 | pIC50 | 2900 | nM | IC50 | Bioorg Med Chem (2021) 42: 116269-116269 [PMID:34130217] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's spectrophotometric method | B | 5.56 | pIC50 | 2770 | nM | IC50 | Eur J Med Chem (2019) 178: 243-258 [PMID:31185414] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.57 | pIC50 | 2670 | nM | IC50 | Bioorg Med Chem (2014) 22: 3806-3814 [PMID:24934993] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 60 to 300 sec by Ellman's method | B | 5.59 | pIC50 | 2600 | nM | IC50 | Medchemcomm (2015) 6: 1930-1941 |
| ChEMBL | Inhibition of human erythrocytes acetylcholinesterase after 15 mins | B | 5.59 | pIC50 | 2600 | nM | IC50 | J Nat Prod (2011) 74: 86-89 [PMID:21189039] |
| ChEMBL | Inhibition of human recombinant AChE | B | 5.68 | pIC50 | 2100 | nM | IC50 | J Med Chem (2010) 53: 745-751 [PMID:20025280] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide substrate by Ellman's method based spectrophotometry | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2013) 21: 1696-1707 [PMID:23454132] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2979-2983 [PMID:23570788] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem (2014) 22: 1318-1328 [PMID:24461561] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.68 | pIC50 | 2090 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126789-126789 [PMID:31753696] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine as substrate by Ellman's method | B | 5.7 | pIC50 | 2010 | nM | IC50 | Bioorg Med Chem Lett (2021) 51: 128374-128374 [PMID:34555506] |
| ChEMBL | Inhibition of human recombinant acetylcholinesterase | B | 5.7 | pIC50 | 2010 | nM | IC50 | J Med Chem (2007) 50: 4882-4897 [PMID:17850125] |
| ChEMBL | Inhibition of human recombinant AChE by Ellman's assay | B | 5.7 | pIC50 | 2010 | nM | IC50 | J Med Chem (2008) 51: 7308-7312 [PMID:18954037] |
| ChEMBL | Inhibition of human AChE | B | 5.7 | pIC50 | 2010 | nM | IC50 | J Med Chem (2013) 56: 7615-7624 [PMID:23984975] |
| ChEMBL | Inhibition of human acetylcholine esterase preincubated for 10 mins followed by the addition of 550 uM of acetylcholine iodide as substrate measured after 20 mins by Ellman's method | B | 5.7 | pIC50 | 2010 | nM | IC50 | Eur J Med Chem (2016) 108: 687-700 [PMID:26735910] |
| ChEMBL | Inhibition of AChE (unknown origin) by Ellman method | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2614-2618 [PMID:23540646] |
| ChEMBL | Inhibition of AChE (unknown origin) assessed as reduction in acetylthiocholine iodide hydrolysis after 15 mins by Ellman method | B | 5.7 | pIC50 | 2000 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 626-630 [PMID:25537270] |
| ChEMBL | Inhibition of human erythrocyte AChE using S-acetylthiocholine iodide as substrate pretreated for 20 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 5.72 | pIC50 | 1900 | nM | IC50 | J Nat Prod (2018) 81: 364-370 [PMID:29400966] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by Ellman's method | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Nat Prod (2019) 82: 239-248 [PMID:30701972] |
| ChEMBL | Inhibition of human AChE using acetylthiocholine iodide as substrate measured for 1 min by spectrophotometric based Ellman's method | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Nat Prod (2020) 83: 1359-1367 [PMID:32309949] |
| ChEMBL | Inhibition of AChE (unknown origin) using acetylthiocholine iodide as substrate by spectrophotometry based Ellman's method | B | 5.8 | pIC50 | 1600 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1194-1198 [PMID:30910460] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) assessed as reduction in formation of 5-thio-2-nitrobenzoate from acetylthiocholine iodide preincubated for 15 mins followed by substrate addition measured after 30 mins by Ellman's method | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 228-231 [PMID:27914796] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 5.9 | pIC50 | 1270 | nM | IC50 | J Nat Prod (2017) 80: 2462-2471 [PMID:28898076] |
| ChEMBL | Inhibition of human AChE by Ellman's assay | B | 5.93 | pIC50 | 1180 | nM | IC50 | J Nat Prod (2006) 69: 1341-1346 [PMID:16989531] |
| ChEMBL | DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) | B | 5.94 | pIC50 | 1156 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | Inhibition of AChE (unknown origin) by Ellman colorimetric method | B | 5.96 | pIC50 | 1100 | nM | IC50 | Eur J Med Chem (2014) 78: 392-400 [PMID:24704612] |
| ChEMBL | Inhibition of human AChE | B | 5.97 | pIC50 | 1070 | nM | IC50 | Eur J Med Chem (2017) 136: 294-304 [PMID:28505534] |
| ChEMBL | Inhibition of AChE by Ellman method | B | 5.97 | pIC50 | 1070 | nM | IC50 | J Nat Prod (2007) 70: 1458-1461 [PMID:17822295] |
| ChEMBL | Inhibition of human AChE pre-incubated for 10 mins before acetylthiocholine iodide substrate addition | B | 6 | pIC50 | 1000 | nM | IC50 | J Nat Prod (2012) 75: 1400-1404 [PMID:22775474] |
| ChEMBL | Inhibition of AChE by microplate assay | B | 6.01 | pIC50 | 980 | nM | IC50 | J Nat Prod (2000) 63: 803-806 [PMID:10869205] |
| ChEMBL | Inhibition of human erythrocytes AChE | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Inhibitory concentration against human erythrocyte Acetylcholinesterase | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Inhibition of human plasma AChE | B | 6.1 | pIC50 | 800 | nM | IC50 | Eur J Med Chem (2011) 46: 2170-2184 [PMID:21459491] |
| ChEMBL | Ex vivo inhibition of human erythrocyte Acetylcholinesterase. | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2002) 45: 3684-3691 [PMID:12166941] |
| ChEMBL | Anticholinesterase activity against human erythrocyte AChE | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibition of AChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 6.1 | pIC50 | 790 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
| ChEMBL | Inhibition of human recombinant AChE using acetylthiocholine iodide substrate incubated for 15 mins by spectrophotometry based Ellman's method | B | 6.15 | pIC50 | 700 | nM | IC50 | Bioorg Med Chem (2014) 22: 5141-5154 [PMID:25189690] |
| ChEMBL | Inhibition of AChE | B | 6.2 | pIC50 | 635.33 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition by Ellmans method | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem (2017) 25: 2057-2064 [PMID:28279561] |
| ChEMBL | Inhibition of AChE | B | 6.22 | pIC50 | 600 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of AChE in human erythrocytes by Ellman's method | B | 6.22 | pIC50 | 600 | nM | IC50 | J Med Chem (2010) 53: 5129-5143 [PMID:20575555] |
| ChEMBL | Inhibition of AChE activity | B | 6.23 | pIC50 | 590 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 2170-2172 [PMID:16483771] |
| ChEMBL | Inhibition of human AChE by spectrophotometry | B | 6.26 | pIC50 | 550 | nM | IC50 | J Nat Prod (2014) 77: 894-901 [PMID:24606395] |
| ChEMBL | Inhibition of AChE by Ellman's method | B | 6.28 | pIC50 | 530 | nM | IC50 | J Nat Prod (2010) 73: 1858-1862 [PMID:20954721] |
| GtoPdb | - | - | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2565-8 [PMID:12182861] |
| ChEMBL | Inhibition of acetylcholinesterase | B | 6.3 | pIC50 | 500 | nM | IC50 | J Nat Prod (2008) 71: 1481-1484 [PMID:18681480] |
| ChEMBL | Inhibition of AchE | B | 6.3 | pIC50 | 500 | nM | IC50 | Bioorg Med Chem (2008) 16: 7691-7697 [PMID:18650096] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) using acetylthiocholine iodide as substrate incubated for 15 min prior to substrate addition measured for 15 min by spectrophotometric analysis | B | 6.3 | pIC50 | 500 | nM | IC50 | Med Chem Res (2012) 21: 2772-2778 |
| ChEMBL | In vitro inhibition of human recombinant AChE. | B | 6.3 | pIC50 | ~500 | nM | IC50 | Bioorg Med Chem Lett (2002) 12: 2565-2568 [PMID:12182861] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6.45 | pIC50 | 355 | nM | IC50 | J Med Chem (2018) 61: 119-139 [PMID:29227101] |
| ChEMBL | Inhibition of AChE (unknown origin) | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 4848-4853 [PMID:26159481] |
| ChEMBL | Inhibition of AChE-induced amyloid beta aggregation | B | 6.46 | pIC50 | 350 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144] |
| ChEMBL | Inhibition of human AChE | B | 6.46 | pIC50 | 350 | nM | IC50 | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
| ChEMBL | Inhibition of acetylcholinesterase (unknown origin) | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476] |
| ChEMBL | Inhibition AChE (unknown origin) using ATCI as substrate assessed as hydrolysis of ATCI after 10 mins measured every 1 min for 10 times | B | 6.52 | pIC50 | 300 | nM | IC50 | J Nat Prod (2016) 79: 281-292 [PMID:26841168] |
| ChEMBL | Inhibition of human AChE by Ellman's method | B | 6.52 | pIC50 | 300 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 2885-2888 [PMID:22425563] |
| ChEMBL | Inhibitory activity against acetylcholinesterase in human RBC | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 737-742 |
| ChEMBL | In vitro reversal of vecuronium-induced neuromuscular block in guinea pig hemi-diaphragm. | F | 5.96 | pEC50 | 1100 | nM | EC50 | Bioorg Med Chem Lett (2002) 12: 2565-2568 [PMID:12182861] |
| Acetylcholinesterase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4768] [UniProtKB: P23795] | ||||||||
| ChEMBL | Inhibition of bovine AChE by Elman's method | B | 5.06 | pIC50 | 8700 | nM | IC50 | Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3198] [GtoPdb: 2465] [UniProtKB: P21836] | ||||||||
| ChEMBL | Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate incubated 10 mins prior to substrate addition measured after 10 mins by Ellman's method | B | 5.6 | pIC50 | 2500 | nM | IC50 | Bioorg Med Chem (2014) 22: 1262-1267 [PMID:24485122] |
| ChEMBL | Inhibition of ICR mouse brain AChE using acetylthiocholine iodide as substrate preincubated for 10 mins before substrate addition by modified Ellman's method | B | 5.68 | pIC50 | 2080 | nM | IC50 | Bioorg Med Chem (2015) 23: 231-240 [PMID:25468034] |
| acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3199] [GtoPdb: 2465] [UniProtKB: P37136] | ||||||||
| ChEMBL | Inhibition of AChE in Wistar rat brain homogenates using acetylthiocholine iodide and DTNB as substrate after 10 mins by Ellman method | B | 5.59 | pIC50 | 2550 | nM | IC50 | J Med Chem (2012) 55: 9708-9721 [PMID:23033965] |
| ChEMBL | Inhibitory activity against acetylcholinesterase in rat brain | B | 5.75 | pIC50 | 1760 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 737-742 |
| ChEMBL | Inhibition of AChE from rat cortex homogenate by Ellmans method | B | 5.93 | pIC50 | 1165 | nM | IC50 | Eur J Med Chem (2009) 44: 772-784 [PMID:18550228] |
| ChEMBL | Inhibition of rat brain acetylcholinesterase by colorimetric method | B | 6.04 | pIC50 | 920 | nM | IC50 | J Nat Prod (2004) 67: 1882-1885 [PMID:15568781] |
| ChEMBL | Inhibition against acetylcholinesterase (AChE) | B | 6.12 | pIC50 | 750 | nM | IC50 | J Med Chem (1994) 37: 689-695 [PMID:8126709] |
| ChEMBL | Acetylcholinesterase inhibitory activity in rat striatal homogenates | B | 6.2 | pIC50 | 630 | nM | IC50 | J Med Chem (1995) 38: 3645-3651 [PMID:7658452] |
| ChEMBL | In vitro inhibitory effect on rat Acetylcholinesterase | B | 6.27 | pIC50 | 538 | nM | IC50 | J Med Chem (1995) 38: 2969-2973 [PMID:7636858] |
| butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
| ChEMBL | Inhibition of BChE (unknown origin) pre-incubated for 15 mins before S-butyrylthiocholine chloride substrate addition and measured after 30 mins by colorimetric Ellman's method | B | 4.55 | pKi | 28290 | nM | Ki | Bioorg Med Chem (2016) 24: 4464-4469 [PMID:27492195] |
| ChEMBL | Inhibition of human BChE assessed as acetylthiocholine hydrolysis | B | 6.72 | pKi | 192.5 | nM | Ki | Bioorg Med Chem (2014) 22: 4784-4791 [PMID:25088549] |
| ChEMBL | Inhibition of human recombinant BChE using acetylthiocholine as substrate | B | 6.72 | pKi | 192.47 | nM | Ki | Bioorg Med Chem (2012) 20: 6739-6750 [PMID:23041347] |
| ChEMBL | Inhibition of human BuChE | B | 1.73 | pIC50 | 18600000 | nM | IC50 | J Med Chem (2008) 51: 3154-3170 [PMID:18479118] |
| ChEMBL | Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 60 to 300 sec by Ellman's method | B | 4.18 | pIC50 | 66500 | nM | IC50 | Medchemcomm (2015) 6: 1930-1941 |
| ChEMBL | Inhibition of BChE by spectrophotometry | B | 4.29 | pIC50 | 50900 | nM | IC50 | J Nat Prod (2009) 72: 500-502 [PMID:19215141] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by Ellman's method | B | 4.37 | pIC50 | 42300 | nM | IC50 | J Nat Prod (2019) 82: 239-248 [PMID:30701972] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine iodide as substrate measured for 1 min by spectrophotometric based Ellman's method | B | 4.38 | pIC50 | 42000 | nM | IC50 | J Nat Prod (2020) 83: 1359-1367 [PMID:32309949] |
| ChEMBL | Inhibition of human plasma BuChE using butyrylthiocholine as substrate measured after 5 mins by Ellman's method | B | 4.5 | pIC50 | 31600 | nM | IC50 | Eur J Med Chem (2020) 191: 112140-112140 [PMID:32088494] |
| ChEMBL | Inhibition of human BuChE using butyrylthiocholine chloride as substrate by Ellman's method | B | 4.53 | pIC50 | 29310 | nM | IC50 | Bioorg Med Chem Lett (2021) 51: 128374-128374 [PMID:34555506] |
| ChEMBL | Inhibition of human recombinant BuChE using butyrylthiocholine iodide substrate incubated for 15 mins by spectrophotometry based Ellman's method | B | 4.66 | pIC50 | 21900 | nM | IC50 | Bioorg Med Chem (2014) 22: 5141-5154 [PMID:25189690] |
| ChEMBL | Inhibition of human recombinant butyrylcholinesterase | B | 4.68 | pIC50 | 20700 | nM | IC50 | J Med Chem (2007) 50: 4882-4897 [PMID:17850125] |
| ChEMBL | Inhibition of human serum BChE by Ellman's assay | B | 4.68 | pIC50 | 20700 | nM | IC50 | J Med Chem (2008) 51: 7308-7312 [PMID:18954037] |
| ChEMBL | Inhibition of human recombinant BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's spectrophotometric method | B | 4.68 | pIC50 | 20700 | nM | IC50 | Eur J Med Chem (2019) 178: 243-258 [PMID:31185414] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem Lett (2020) 30: 126789-126789 [PMID:31753696] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 4.72 | pIC50 | 19100 | nM | IC50 | J Med Chem (2018) 61: 119-139 [PMID:29227101] |
| ChEMBL | Inhibition of BChE | B | 4.73 | pIC50 | 18600 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 2687-2691 [PMID:21216144] |
| ChEMBL | In vitro inhibitory activity against Butyrylcholinesterase (BChE) in human serum | B | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2389-2391 [PMID:12824041] |
| ChEMBL | Inhibition of BuChE in human serum using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 10 mins followed by substrate addition measured for 15 mins by Ellman's method | B | 4.78 | pIC50 | 16500 | nM | IC50 | Eur J Med Chem (2019) 179: 404-422 [PMID:31265934] |
| ChEMBL | Inhibition of BuChE in human serum using butyrylthiocholine iodide as substrate measured every 30s for 5 mins by Ellman's spectrophotometric method | B | 4.8 | pIC50 | 15800 | nM | IC50 | Eur J Med Chem (2014) 75: 21-30 [PMID:24508831] |
| ChEMBL | Inhibition of BuChE (unknown origin) preincubated for 30 mins followed by substrate addition acetylthiocholineiodide measured after 40 mins by Ellman's method | B | 4.86 | pIC50 | 13700 | nM | IC50 | Eur J Med Chem (2020) 200: 112415-112415 [PMID:32454229] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate by spectrophotometry based Ellman's method | B | 4.88 | pIC50 | 13180 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1194-1198 [PMID:30910460] |
| ChEMBL | Inhibition of BuChE (unknown origin) | B | 4.9 | pIC50 | 12700 | nM | IC50 | Bioorg Med Chem (2014) 22: 3806-3814 [PMID:24934993] |
| ChEMBL | Inhibition of human serum BuChe using butyrylthiocholine iodide as substrate incubated for 25 mins by DTNB reagent based Ellman's method | B | 4.97 | pIC50 | 10600 | nM | IC50 | Bioorg Med Chem (2021) 42: 116269-116269 [PMID:34130217] |
| ChEMBL | Inhibition of BuChE (unknown origin) by spectrophotometric analysis based Ellman's assay | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2017) 27: 232-236 [PMID:27923619] |
| ChEMBL | Inhibition of human serum BuChE by Ellman's method | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2007) 50: 5311-5323 [PMID:17902635] |
| ChEMBL | Inhibition of BuChE (unknown origin) by Ellman method | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2614-2618 [PMID:23540646] |
| ChEMBL | Inhibition of butyrylcholinesterase | B | 5.07 | pIC50 | 8500 | nM | IC50 | J Nat Prod (2008) 71: 1481-1484 [PMID:18681480] |
| ChEMBL | Inhibition of BChE | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of BChE | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5840-5843 [PMID:16945529] |
| ChEMBL | Inhibition of BchE | B | 5.1 | pIC50 | 8000 | nM | IC50 | Bioorg Med Chem (2008) 16: 7691-7697 [PMID:18650096] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyrylthiocholine chloride as substrate preincubated for 15 min | B | 5.1 | pIC50 | 8000 | nM | IC50 | Med Chem Res (2012) 21: 2329-2339 |
| ChEMBL | Inhibitory concentration against human plasma Butyrylcholinesterase | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (2005) 48: 986-994 [PMID:15715468] |
| ChEMBL | Ex vivo inhibition of human plasma Butyrylcholinesterase. | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (2002) 45: 3684-3691 [PMID:12166941] |
| ChEMBL | Anticholinesterase activity against human plasma BChE | B | 5.14 | pIC50 | 7300 | nM | IC50 | J Med Chem (2006) 49: 2174-2185 [PMID:16570913] |
| ChEMBL | Inhibition of BChE (unknown origin) | B | 5.15 | pIC50 | 7000 | nM | IC50 | Eur J Med Chem (2018) 156: 598-617 [PMID:30031971] |
| ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) | B | 5.15 | pIC50 | 7000 | nM | IC50 | Bioorg Med Chem (2013) 21: 146-152 [PMID:23199476] |
| ChEMBL | Inhibition of BChE (unknown origin) using thiocholine as substrate preincubated for 15 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 5.43 | pIC50 | 3720 | nM | IC50 | Eur J Med Chem (2018) 143: 1301-1311 [PMID:29126732] |
| ChEMBL | Inhibition of BChE (unknown origin) using butyrylthiocholine iodide as substrate pretreated for 15 mins followed by substrate addition and measured by DTNB reagent based assay relative to control | B | 5.7 | pIC50 | 2000 | nM | IC50 | J Nat Prod (2018) 81: 1693-1700 [PMID:30040425] |
| ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) using acetylthiocholine as substrate preincubated for 20 mins followed by substrate addition by Ellmans method | B | 5.92 | pIC50 | 1200 | nM | IC50 | Bioorg Med Chem (2017) 25: 2057-2064 [PMID:28279561] |
| ChEMBL | Inhibition of human Cholinesterase | B | 6.24 | pIC50 | 575 | nM | IC50 | Bioorg Med Chem (2019) 27: 895-930 [PMID:30744931] |
| ChEMBL | Inhibition of butyrylcholinesterase (unknown origin) using butyrylthiocholine chloride as substrate incubated for 15 min prior to substrate addition measured for 15 min by spectrophotometric analysis | B | 6.77 | pIC50 | 170 | nM | IC50 | Med Chem Res (2012) 21: 2772-2778 |
| Butyrylcholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5077] [UniProtKB: Q9N1N9] | ||||||||
| ChEMBL | Inhibitory activity against BuChE from horse serum | B | 5.1 | pKi | 8000 | nM | Ki | Bioorg Med Chem Lett (2006) 16: 573-580 [PMID:16274989] |
| ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine chloride as substrate preincubated for 15 mins by Ellman's method | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2011) 19: 7228-7235 [PMID:22041172] |
| ChEMBL | Inhibition of equine serum Butyrylcholinesterase | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2011) 19: 2298-2305 [PMID:21397508] |
| ChEMBL | Inhibition of BuChE in horse serum | B | 4.82 | pIC50 | 15240 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 2123-2125 [PMID:17317172] |
| ChEMBL | Inhibition of equine serum BuChE | B | 4.84 | pIC50 | 14400 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 3765-3768 [PMID:17451950] |
| ChEMBL | Inhibitory activity against BuChE from horse serum | B | 5.07 | pIC50 | 8500 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 573-580 [PMID:16274989] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's assay | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem (2008) 16: 4252-4261 [PMID:18343673] |
| ChEMBL | Inhibition of horse serum BChE | B | 5.08 | pIC50 | 8400 | nM | IC50 | J Med Chem (2006) 49: 5411-5413 [PMID:16942014] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's assay | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Bioorg Med Chem (2008) 16: 4252-4261 [PMID:18343673] |
| ChEMBL | Inhibition of horse serum BChE | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | J Med Chem (2006) 49: 5411-5413 [PMID:16942014] |
| Butyrylcholinesterase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3403] [UniProtKB: Q9JKC1] | ||||||||
| ChEMBL | Inhibition of BChE from rat serum by Ellmans method | B | 5.23 | pIC50 | 5900 | nM | IC50 | Eur J Med Chem (2009) 44: 772-784 [PMID:18550228] |
| Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908] | ||||||||
| ChEMBL | Inhibition of equine serum BuChE assessed as dissociation constant for enzyme-inhibitor complex using butyrylthiocholine iodide as substrate measured for 125 secs by Ellman's method | B | 5.11 | pKi | 7700 | nM | Ki | Eur J Med Chem (2019) 181: 111550-111550 [PMID:31376562] |
| ChEMBL | Inhibition of horse serum butyrylcholinesterase by Ellman's method | B | 4.34 | pIC50 | 46030 | nM | IC50 | Eur J Med Chem (2016) 124: 270-283 [PMID:27592396] |
| ChEMBL | Inhibition of horse serum BChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 5 mins for 15 mins by spectrophotometric method | B | 4.39 | pIC50 | 40720 | nM | IC50 | Bioorg Med Chem Lett (2018) 28: 2481-2484 [PMID:29887354] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 4.41 | pIC50 | 39030 | nM | IC50 | Eur J Med Chem (2014) 76: 376-386 [PMID:24594525] |
| ChEMBL | Inhibition of equine BChE using S-butyrylthiocholine chloride as substrate by Ellman's method | B | 4.55 | pIC50 | 28300 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2308-2313 [PMID:26995529] |
| ChEMBL | Inhibition of equine BChE using BTC as substrate preincubated for 5 mins followed by substrate addition measured after 2 mins by Ellman's assay | B | 4.55 | pIC50 | 28100 | nM | IC50 | Bioorg Med Chem (2016) 24: 886-893 [PMID:26795115] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.61 | pIC50 | 24410 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1325-1329 [PMID:30956012] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 4.61 | pIC50 | 24400 | nM | IC50 | Bioorg Med Chem (2010) 18: 2173-2177 [PMID:20176490] |
| ChEMBL | Inhibition of equine serum BuChE using ATCI as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by DTNB-based spectrophotometric analysis | B | 4.65 | pIC50 | 22390 | nM | IC50 | J Nat Prod (2016) 79: 1241-1248 [PMID:27096334] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | B | 4.66 | pIC50 | 21850 | nM | IC50 | Eur J Med Chem (2017) 137: 280-291 [PMID:28605675] |
| ChEMBL | Inhibition of horse serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured after 5 mins by Ellman's method | B | 4.7 | pIC50 | 19780 | nM | IC50 | Eur J Med Chem (2016) 107: 219-232 [PMID:26588065] |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins by spectrophotometer analysis | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1815-1819 [PMID:24594354] |
| ChEMBL | Inhibition of equine serum butyrylcholinesterase using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2014) 22: 906-916 [PMID:24369842] |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2014) 22: 1318-1328 [PMID:24461561] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2019) 27: 2621-2628 [PMID:30952387] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride substrate by Ellman's method based spectrophotometry | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2013) 21: 1696-1707 [PMID:23454132] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2979-2983 [PMID:23570788] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method | B | 4.71 | pIC50 | 19340 | nM | IC50 | Bioorg Med Chem (2013) 21: 3022-3031 [PMID:23602518] |
| ChEMBL | Inhibition of horse serum BChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by Ellman's microplate assay | B | 4.71 | pIC50 | 19340 | nM | IC50 | Eur J Med Chem (2013) 67: 221-229 [PMID:23871902] |
| ChEMBL | Inhibition of horse serum BuChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.74 | pIC50 | 18130 | nM | IC50 | Bioorg Med Chem (2017) 25: 1352-1363 [PMID:28089589] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.76 | pIC50 | 17380 | nM | IC50 | Bioorg Med Chem (2018) 26: 3731-3762 [PMID:30017112] |
| ChEMBL | Inhibition of horse serum butyrylcholinesterase using butyrylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by Ellman's method | B | 4.76 | pIC50 | 17380 | nM | IC50 | Eur J Med Chem (2015) 102: 80-92 [PMID:26244990] |
| ChEMBL | Inhibition of equine serum BuChE preincubated for 6 mins followed by addition of S-butyrylthiocholine iodide by Ellman's method | B | 4.79 | pIC50 | 16320 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 3881-3885 [PMID:27426301] |
| ChEMBL | Inhibition of equine serum BuChE preincubated for 5 mins followed by addition of butyrylthiocholine iodide as substrate measured after 2 mins by Ellman's method | B | 4.8 | pIC50 | 15800 | nM | IC50 | Eur J Med Chem (2016) 119: 260-277 [PMID:27227482] |
| ChEMBL | Inhibition of equine serum BuChE using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric analysis | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2017) 25: 2946-2955 [PMID:28454848] |
| ChEMBL | Inhibition of horse serum BChE by Ellman's method | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2010) 18: 1244-1251 [PMID:20056426] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's method | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem (2010) 18: 4475-4484 [PMID:20471843] |
| ChEMBL | Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured every 1 min by Ellman's assay | B | 4.8 | pIC50 | 15700 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4462-4466 [PMID:22633691] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's method | B | 4.84 | pIC50 | 14400 | nM | IC50 | Eur J Med Chem (2009) 44: 2523-2532 [PMID:19243862] |
| ChEMBL | Inhibition of horse BuChE using S-butyrylcholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | B | 4.87 | pIC50 | 13610 | nM | IC50 | Medchemcomm (2014) 5: 609-616 |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine chloride as substrate incubated for 6 mins by spectrophotometric method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Bioorg Med Chem (2014) 22: 6089-6104 [PMID:25282654] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate incubated for 6 mins prior to substrate addition measured after 60 to 180 secs by Ellman's method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 2636-2641 [PMID:23511019] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylcholinesterase iodide as substrate preincubated for 6 mins followed by substrate addition by Ellmans method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Eur J Med Chem (2013) 69: 632-646 [PMID:24095756] |
| ChEMBL | Inhibition of equine serum BChE using S-butyrylthiocholine iodide as substrate preincubated for 6 mins prior to substrate addition measured at 60 to 180 seconds by Ellman's method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Eur J Med Chem (2013) 64: 540-553 [PMID:23685572] |
| ChEMBL | Inhibition of BuChE in equine serum using S-butyrylthiocholine iodide as substrate preincubated with enzyme for 6 mins followed by substrate addition by Ellman's method | B | 4.9 | pIC50 | 12700 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 2368-2373 [PMID:24726809] |
| ChEMBL | Inhibition of equine BuChE using butyrylthiocholine iodide as substrate after 5 mins by DTNB method | B | 4.9 | pIC50 | 12600 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 4707-4712 [PMID:22704921] |
| ChEMBL | Inhibition of equine serum BChE using butyrylthiocholine as substrate preincubated for 20 mins followed by substrate addition and measured upto 5 mins by Ellman's method | B | 4.92 | pIC50 | 12000 | nM | IC50 | Eur J Med Chem (2019) 177: 414-424 [PMID:31158754] |
| ChEMBL | Inhibition of horse serum BChE using butyrylcholine chloride as substrate preincubated for 15 mins followed by substrate addition by spectrophotometric method | B | 4.92 | pIC50 | 12000 | nM | IC50 | Bioorg Med Chem (2017) 25: 3368-3376 [PMID:28457693] |
| ChEMBL | Inhibition of equine serum BuChE by Ellman's method | B | 4.92 | pIC50 | 12000 | nM | IC50 | J Med Chem (2010) 53: 5129-5143 [PMID:20575555] |
| ChEMBL | Inhibition of horse serum BChE pretreated for 20 mins followed by butyrylthiocholine iodide substrate addition measured for 5 mins by Ellman's method | B | 4.92 | pIC50 | 11900 | nM | IC50 | Eur J Med Chem (2017) 125: 288-298 [PMID:27688184] |
| ChEMBL | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition measured for 5 mins by Ellman's method | B | 5.03 | pIC50 | 9400 | nM | IC50 | Bioorg Med Chem (2018) 26: 4952-4962 [PMID:30190181] |
| ChEMBL | Inhibition of equine serum BChE by modified Ellman's method | B | 5.08 | pIC50 | 8404 | nM | IC50 | J Med Chem (2010) 53: 3611-3617 [PMID:20361801] |
| ChEMBL | Inhibition of Equine serum BChE after 2 mins by colorimetric Ellman assay | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2946-2949 [PMID:20350808] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 5.08 | pIC50 | 8400 | nM | IC50 | Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964] |
| ChEMBL | Inhibition of equine serum BChE by colorimetric Ellman's assay | B | 5.08 | pIC50 | 8400 | nM | IC50 | Eur J Med Chem (2011) 46: 3118-3123 [PMID:21546135] |
| ChEMBL | Inhibition of Equine serum BChE after 2 mins by colorimetric Ellman assay | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2946-2949 [PMID:20350808] |
| ChEMBL | Inhibition of equine serum BChE by Ellman's method | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Bioorg Med Chem (2011) 19: 1222-1235 [PMID:21232964] |
| ChEMBL | Inhibition of equine serum BChE by colorimetric Ellman's assay | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | Eur J Med Chem (2011) 46: 3118-3123 [PMID:21546135] |
| ChEMBL | Inhibition of equine serum BChE by modified Ellman's method | B | 5.08 | pIC50 | 8394.6 | nM | IC50 | J Med Chem (2010) 53: 3611-3617 [PMID:20361801] |
| ChEMBL | Inhibition of equine BChE using after 10 mins by Ellman's method | B | 5.1 | pIC50 | 7960 | nM | IC50 | Bioorg Med Chem (2013) 21: 1735-1748 [PMID:23462716] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as a substrate measured for 125 secs by DNTB reagent based Ellman's method | B | 5.41 | pIC50 | 3900 | nM | IC50 | ACS Med Chem Lett (2021) 12: 1718-1725 [PMID:34795859] |
| ChEMBL | Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured for 45 mins by Ellmans microplate assay | B | 5.48 | pIC50 | 3310 | nM | IC50 | Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576] |
| ChEMBL | Inhibition of horse serum BChE after 2 mins by Ellman's reaction | B | 5.49 | pIC50 | 3200 | nM | IC50 | J Nat Prod (2010) 73: 1879-1883 [PMID:20964319] |
| GluN2B/Glutamate [NMDA] receptor subunit epsilon 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL311] [GtoPdb: 457] [UniProtKB: Q00960] | ||||||||
| ChEMBL | Displacement of [3H]Ifenprodil from NMDAR-2B in Sprague-Dawley rat frontal cortex homogenates after 2 hrs by liquid scintillation counting | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (2012) 55: 9708-9721 [PMID:23033965] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
