prinaberel [Ligand Id: 6700] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL450940 (ERB-041, PF-00913086, Prinaberel) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
| ChEMBL | Inhibitory concentration against human ER alpha expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand | B | 5.92 | pIC50 | 1216 | nM | IC50 | J Med Chem (2004) 47: 5021-5040 [PMID:15456246] |
| GtoPdb | - | - | 5.92 | pIC50 | 1216 | nM | IC50 | J Immunol (2008) 180: 630-6 [PMID:18097065] |
| Estrogen receptor-α/Estrogen receptor alpha in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3065] [GtoPdb: 620] [UniProtKB: P19785] | ||||||||
| GtoPdb | - | - | 6.12 | pIC50 | 750 | nM | IC50 | J Immunol (2008) 180: 630-6 [PMID:18097065] |
| ChEMBL | Inhibition of [3H]17-beta-estradiol binding to mouse ER alpha expressed in Escherichia coli | B | 6.13 | pIC50 | 746 | nM | IC50 | J Med Chem (2004) 47: 5021-5040 [PMID:15456246] |
| Estrogen receptor-α/Estrogen receptor alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2724] [GtoPdb: 620] [UniProtKB: P06211] | ||||||||
| ChEMBL | Inhibition of [3H]17-beta-estradiol binding to rat ER alpha expressed in Escherichia coli | B | 6.21 | pIC50 | 618 | nM | IC50 | J Med Chem (2004) 47: 5021-5040 [PMID:15456246] |
| GtoPdb | - | - | 6.21 | pIC50 | 620 | nM | IC50 | J Immunol (2008) 180: 630-6 [PMID:18097065] |
| Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] | ||||||||
| GtoPdb | - | - | 8.3 | pIC50 | 5 | nM | IC50 |
J Med Chem (2004) 47: 5021-40 [PMID:15456246]; J Immunol (2008) 180: 630-6 [PMID:18097065] |
| ChEMBL | Inhibitory concentration against human ER beta expressed in Escherichia coli was determined using [3H]17-beta-estradiol as radio ligand | B | 8.3 | pIC50 | 5 | nM | IC50 | J Med Chem (2004) 47: 5021-5040 [PMID:15456246] |
| ChEMBL | Binding affinity to ERbeta | B | 8.3 | pIC50 | 5 | nM | IC50 | Eur J Med Chem (2008) 43: 43-52 [PMID:17459530] |
| Estrogen receptor-β/Estrogen receptor beta in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2995] [GtoPdb: 621] [UniProtKB: O08537] | ||||||||
| GtoPdb | - | - | 8.43 | pIC50 | 3.7 | nM | IC50 | J Immunol (2008) 180: 630-6 [PMID:18097065] |
| ChEMBL | Inhibition of [3H]17-beta-estradiol binding to mouse ER beta expressed in Escherichia coli | B | 8.43 | pIC50 | 3.7 | nM | IC50 | J Med Chem (2004) 47: 5021-5040 [PMID:15456246] |
| Estrogen receptor-β/Estrogen receptor beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3021] [GtoPdb: 621] [UniProtKB: Q62986] | ||||||||
| ChEMBL | Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coli | B | 8.5 | pIC50 | 3.14 | nM | IC50 | J Med Chem (2004) 47: 5021-5040 [PMID:15456246] |
| GtoPdb | - | - | 8.51 | pIC50 | 3.1 | nM | IC50 | J Immunol (2008) 180: 630-6 [PMID:18097065] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
