compound 1 [PMID: 22533316] [Ligand Id: 6709] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL481608 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cycloartenol synthase in Arabidopsis thaliana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5356] [UniProtKB: P38605] | ||||||||
| ChEMBL | Inhibition of Arabidopsis thaliana cycloartenol synthase expressed in Saccharomyces cerevisiae SMY8 | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 718-723 [PMID:19119009] |
| lanosterol synthase/Lanosterol synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3593] [GtoPdb: 2434] [UniProtKB: P48449] | ||||||||
| ChEMBL | Inhibition of human OSC expressed in Saccharomyces cerevisiae SMY8 | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 718-723 [PMID:19119009] |
| ChEMBL | Inhibition of human liver microsome 2,3-OSC after 1 hr by Silica gel plate phosphor imaging | B | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2012) 55: 4990-5002 [PMID:22533316] |
| GtoPdb | - | - | 8.1 | pIC50 | 8 | nM | IC50 | J Med Chem (2012) 55: 4990-5002 [PMID:22533316] |
| Lanosterol synthase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5355] [UniProtKB: P38604] | ||||||||
| ChEMBL | Inhibition of yeast OSC expressed in Saccharomyces cerevisiae SMY8 | B | 6.49 | pIC50 | 320 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 718-723 [PMID:19119009] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
