ChEMBL ligand: CHEMBL18 (Cardrase, Ethamide, Ethoxzolamide, NSC-10679)
AGAP002992-PA in Anopheles gambiae [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56] There should be some charts here, you may need to enable JavaScript!
Alpha carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02] There should be some charts here, you may need to enable JavaScript!
Astrosclerin-3 in Astrosclera willeyana [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1] There should be some charts here, you may need to enable JavaScript!
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase in Mycobacterium tuberculosis [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9] Carbonic anhydrase in Methanosarcina thermophila [ChEMBL: CHEMBL3932] [UniProtKB: P40881] Carbonic anhydrase in Stylophora pistillata [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24] Carbonic anhydrase in Methanobacterium thermoautotrophicum [ChEMBL: CHEMBL3926] [UniProtKB: Q50565] Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71] Carbonic anhydrase in Candida glabrata CBS 138 [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6] Carbonic anhydrase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL5931] [UniProtKB: P53615] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) [ChEMBL: CHEMBL4211] [UniProtKB: O24855] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 15 in Mouse [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase 3 in Bovine [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase III in Human [ChEMBL: CHEMBL2885] [UniProtKB: P07451] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] Carbonic anhydrase IV in Bovine [ChEMBL: CHEMBL281] [UniProtKB: Q95323] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 5A/Carbonic anhydrase VA in Human [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VB in Human [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0] There should be some charts here, you may need to enable JavaScript!
Carbonic anhydrase VI in Human [ChEMBL: CHEMBL3025] [UniProtKB: P23280] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 13/Carbonic anhydrase XIII in Human [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1] carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1] There should be some charts here, you may need to enable JavaScript!
carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7] There should be some charts here, you may need to enable JavaScript!
Delta carbonic anhydrase in Thalassiosira weissflogii [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1] There should be some charts here, you may need to enable JavaScript!
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
AGAP002992-PA in Anopheles gambiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399914] [UniProtKB: Q5TU56]
ChEMBL	Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	6.73	pKi	185	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
Alpha carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075028] [UniProtKB: B5SU02]
ChEMBL	Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay	B	7.4	pKi	39.4	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay	B	7.4	pKi	39.4	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Astrosclerin-3 in Astrosclera willeyana (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944499] [UniProtKB: A6YCJ1]
ChEMBL	Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	6.41	pKi	387	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
Carbonate dehydratase in Sulfurihydrogenibium sp. (strain YO3AOP1) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3745586] [UniProtKB: B2V8E3]
ChEMBL	Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.03	pKi	9.3	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
Carbonic anhydrase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6068] [UniProtKB: P9WPJ9]
ChEMBL	Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay	B	7.57	pKi	27	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
Carbonic anhydrase in Methanosarcina thermophila (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3932] [UniProtKB: P40881]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila	B	6.13	pKi	740	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila	B	6.7	pKi	200	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Stylophora pistillata (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1649055] [UniProtKB: C0IX24]
ChEMBL	Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	6.98	pKi	105	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
Carbonic anhydrase in Methanobacterium thermoautotrophicum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3926] [UniProtKB: Q50565]
ChEMBL	Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum	B	5.27	pKi	5350	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
Carbonic anhydrase in Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5337] [UniProtKB: Q5AJ71]
ChEMBL	Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assay	B	5.97	pKi	1070	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay	B	5.97	pKi	1070	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay	B	5.97	pKi	1070	nM	Ki	Bioorg Med Chem Lett (2010) 20: 2508-2511 [PMID:20299219]
ChEMBL	Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	5.97	pKi	1070	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase in Candida glabrata CBS 138 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6185] [UniProtKB: Q6FTL6]
ChEMBL	Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay	B	5.51	pKi	3125	nM	Ki	Bioorg Med Chem Lett (2013) 23: 2647-2652 [PMID:23511020]
Carbonic anhydrase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5931] [UniProtKB: P53615]
ChEMBL	Inhibition of Saccharomyces cerevisiae carbonic anhydrase by oxygen-18 isotope exchange assay	B	4.8	pKi	16000	nM	Ki	Bioorg Med Chem Lett (2008) 18: 6327-6331 [PMID:18993072]
ChEMBL	Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay	B	7.01	pKi	98.4	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
Carbonic anhydrase 1 in Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4211] [UniProtKB: O24855]
ChEMBL	Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay	B	6.71	pKi	193	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of Helicobacter pylori recombinant CA	B	6.81	pKi	155	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay	B	7.24	pKi	58	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of full length mouse carbonic anhydrase 15 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.24	pKi	58	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
Carbonic anhydrase 2 in Cryptococcus neoformans var. grubii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697676] [UniProtKB: Q3I4V7]
ChEMBL	Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	7.06	pKi	87	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
Carbonic anhydrase 3 in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1944498] [UniProtKB: Q3SZX4]
ChEMBL	Inhibition of bovine carbonic anhydrase 3 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	5.02	pKi	9443	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
Carbonic anhydrase, alpha family in Thiomicrospira crunogena (strain XCL-2) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3621035] [UniProtKB: Q31FD6]
ChEMBL	Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay	B	8.39	pKi	4.1	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL	Binding affinity to human recombinant CA1 at 37 degC and pH 7.0 by thermal shift assay	B	7.85	pKd	14	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) by thermal shift assay	B	7.85	pKd	14	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human carbonic anhydrase 1 esterase activity using 4-nitrophenylacetate as substrate	B	5.43	pKi	3750	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	5.43	pKi	3750	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase I expressed in Escherichia coli strain BL21	B	5.92	pKi	1200	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25.2	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
GtoPdb	-	-	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-54 [PMID:15686931]; Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I (CA1)	B	7.6	pKi	25	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibition of cloned human cytosolic isozyme Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method.	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase I (hCA I)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I (CA1)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human recombinant carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibitory activity against human carbonic anhydrase I.	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase I (hCAI)	B	7.6	pKi	25	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against Human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Ki value against human carbonic anhydrase I (hCA I)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Ki value against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCAI)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli BL21	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory activity against human carbonic anhydrase I at 0.09 uM	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA I) by the CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase I	F	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition constant against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase I (hCA I)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase I by the CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA1	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of human cloned CA1 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method	B	7.6	pKi	25	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant isozyme CA1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA1 by CO2 hydration stopped flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human cloned CA1 by CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant full length CA1 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA1 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of full length human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 1	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human cloned CA1 after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA1 cytosolic isoform by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human cloned carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of full length human CA1 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA1 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 1 by by stopped flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition against human carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibitory activity against human carbonic anhydrase I (hCA I)	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition constant determined against human cloned carbonic anhydrase I	B	7.6	pKi	25	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibition of full length carbonic anhydrase-1 in human erythrocytes	B	7.8	pIC50	15.71	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL	Binding affinity to human recombinant CA2 at 37 degC and pH 7.0 by thermal shift assay	B	8.96	pKd	1.1	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 2 by thermal shift assay	B	9.15	pKd	0.71	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of carbonic anhydrase 2 assessed as inhibition of carbon dioxide hydration	B	0.9	pKi	0.9	-	logKi	Eur J Med Chem (2009) 44: 3439-3444 [PMID:19303173]
ChEMBL	Inhibitory activity against human carbonic anhydrase II at 0.01 uM	B	5.1	pKi	8000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibition of human carbonic anhydrase 2 esterase activity using 4-nitrophenylacetate as substrate	B	6.49	pKi	320	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.49	pKi	320	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	6.75	pKi	178	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	B	7.16	pKi	69.7	nM	Ki	Bioorg Med Chem (2012) 20: 2208-2213 [PMID:22386980]
ChEMBL	Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21	B	7.42	pKi	38	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2003) 13: 837-840 [PMID:12617903]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase II (hCA II)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibition of human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase II (CA2)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	Inhibition of human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibitory activity against human carbonic anhydrase II.	B	8.1	pKi	8	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	In vitro inhibitory activity against human carbonic anhydrase II (hCAII)	B	8.1	pKi	8	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against Human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against Carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Ki value against human carbonic anhydrase II (hCA II)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
ChEMBL	Inhibitory activity against cytosolic human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Ki value against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
ChEMBL	Inhibitory activity against human carbonic anhydrase II (hCAII)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory activity against human Carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2004) 47: 5224-5229 [PMID:15456265]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human (cloned) isozyme (hCA II) by CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase II	F	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibitory constant against human Carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition constant against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase II (hCA II)	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibitory activity against human cloned Carbonic anhydrase II by the CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibitory activity against human recombinant cytosolic CA2	B	8.1	pKi	8	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 2117-2126 [PMID:16539401]
ChEMBL	Inhibition of human recombinant CA2	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2006) 16: 2182-2188 [PMID:16459077]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of human cloned CA2 by stopped-flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method	B	8.1	pKi	8	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human recombinant isozyme CA2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA2 by CO2 hydration stopped flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human cloned CA2 by CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant full length CA2 expressed in Escherichia coli BL21 (DE3) by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	J Med Chem (2009) 52: 2226-2232 [PMID:19317447]
ChEMBL	Inhibition of human recombinant full length CA2 by stopped-flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2009) 17: 1158-1163 [PMID:19124253]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 2642-2645 [PMID:19375309]
ChEMBL	Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2009) 17: 4503-4509 [PMID:19450983]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2009) 17: 5054-5058 [PMID:19520577]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 6649-6654 [PMID:19846301]
ChEMBL	Inhibition of full length human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 2	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2010) 18: 5498-5503 [PMID:20624682]
ChEMBL	Inhibition of human cloned CA2 after 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2011) 19: 1172-1178 [PMID:21251841]
ChEMBL	Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
ChEMBL	Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2011) 19: 1847-1851 [PMID:21377369]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2011) 19: 5023-5030 [PMID:21757360]
ChEMBL	Inhibition of human cloned carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2012) 20: 1403-1410 [PMID:22285172]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4184-4190 [PMID:27485387]
ChEMBL	Inhibition against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibitory activity against human carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH)	B	8.1	pKi	8	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibition of human recombinant carbonic anhydrase II (CA2)	B	8.1	pKi	8	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C	B	8.1	pKi	8	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2017) 25: 3555-3561 [PMID:28511911]
ChEMBL	Inhibitory activity against human recombinant carbonic anhydrase II	B	8.1	pKi	8	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	B	8.1	pKi	8	nM	Ki	J Med Chem (2012) 55: 3513-3520 [PMID:22424239]
ChEMBL	Inhibition of full length human CA2 cytosolic isoform preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	J Med Chem (2013) 56: 1761-1771 [PMID:23391336]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2013) 21: 1534-1538 [PMID:22883029]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
ChEMBL	Inhibition of human CA2 cytosolic isoform after 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2014) 22: 2939-2946 [PMID:24792813]
ChEMBL	Inhibition of human cloned cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2014) 22: 4537-4543 [PMID:25129169]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2015) 23: 526-531 [PMID:25533402]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2015) 23: 1728-1734 [PMID:25773015]
ChEMBL	Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2015) 23: 2303-2309 [PMID:25882523]
ChEMBL	Inhibition of human carbonic anhydrase 2 by by stopped flow CO2 hydration method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2015) 25: 3550-3555 [PMID:26174556]
ChEMBL	Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2015) 25: 5485-5489 [PMID:26525863]
ChEMBL	Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2016) 26: 401-405 [PMID:26691758]
ChEMBL	Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem (2016) 24: 1115-1120 [PMID:26850377]
ChEMBL	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1253-1259 [PMID:26832216]
ChEMBL	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2016) 26: 1821-1826 [PMID:26920803]
ChEMBL	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis	B	8.1	pKi	8	nM	Ki	Bioorg Med Chem Lett (2017) 27: 490-495 [PMID:28025002]
ChEMBL	Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method	B	8.27	pKi	5.4	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2315-2320 [PMID:15837316]
ChEMBL	In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dansylamide	B	9.31	pKi	0.49	nM	Ki	J Med Chem (1987) 30: 591-597 [PMID:3560154]
ChEMBL	50% inhibition of human carbonic anhydrase II assayed by CO2 hydration catalyzed by human erythrocytes	B	8.52	pIC50	3	nM	IC50	J Med Chem (1989) 32: 2548-2554 [PMID:2585443]
ChEMBL	In vitro inhibition of human Carbonic Anhydrase II	B	8.52	pIC50	3	nM	IC50	J Med Chem (1989) 32: 2486-2492 [PMID:2810337]
ChEMBL	In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (1987) 30: 591-597 [PMID:3560154]
ChEMBL	Inhibition of full length carbonic anhydrase-2 in human erythrocytes	B	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL	Inhibition of human carbonic anhydrase 3	B	5.3	pKi	5000	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL	Inhibition of human carbonic anhydrase 4 esterase activity using 4-nitrophenylacetate as substrate	B	6.08	pKi	840	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 4 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	6.08	pKi	840	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human carbonic anhydrase 4	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 4 by stopped flow CO2 hydrase assay	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibitory activity against human carbonic anhydrase IV (hCAIV)	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped-flow CO2 hydration method	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human carbonic anhydrase 4 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant full length CA4 by stopped flow CO2 hydration assay	B	7.03	pKi	93	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human cloned CA4 by stopped-flow CO2 hydration method	B	7.03	pKi	93	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
Carbonic anhydrase IV in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL281] [UniProtKB: Q95323]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes	B	7.89	pKi	13	nM	Ki	J Med Chem (2000) 43: 4884-4892 [PMID:11123998]
ChEMBL	Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2003) 13: 2867-2873 [PMID:14611846]
ChEMBL	Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes	B	7.89	pKi	13	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes	B	7.89	pKi	13	nM	Ki	J Med Chem (2000) 43: 4542-4551 [PMID:11087579]
ChEMBL	Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C	B	7.89	pKi	13	nM	Ki	J Med Chem (2004) 47: 1272-1279 [PMID:14971907]
ChEMBL	Inhibitory activity against carbonic anhydrase isolated from bovine lung microsome (bCA IV)	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2003) 13: 841-845 [PMID:12617904]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2002) 12: 1551-1557 [PMID:12039560]
ChEMBL	In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)	B	7.89	pKi	13	nM	Ki	J Med Chem (2004) 47: 2796-2804 [PMID:15139757]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV	B	7.89	pKi	13	nM	Ki	J Med Chem (2002) 45: 1466-1476 [PMID:11906288]
ChEMBL	Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)	B	7.89	pKi	13	nM	Ki	Bioorg Med Chem Lett (2005) 15: 1149-1154 [PMID:15686931]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX at 0.09 uM	B	4.47	pKi	34000	nM	Ki	Bioorg Med Chem Lett (2004) 14: 6001-6006 [PMID:15546717]
ChEMBL	Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2005) 15: 367-372 [PMID:15603956]
ChEMBL	Inhibitory activity against human Carbonic anhydrase IX (hCA IX)	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibition constant against human recombinant carbonic anhydrase IX catalytic domain	F	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3302-3306 [PMID:15908201]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.37	pKi	43	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.46	pKi	34.3	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX.	B	7.47	pKi	34	nM	Ki	J Med Chem (2003) 46: 5471-5477 [PMID:14640555]
ChEMBL	Inhibitory activity against Carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	J Med Chem (2005) 48: 2121-2125 [PMID:15771455]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 579-584 [PMID:15664816]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5427-5433 [PMID:15454239]
ChEMBL	Binding affinity towards human cloned carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5775-5780 [PMID:15501039]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3102-3108 [PMID:15905091]
ChEMBL	Inhibition constant against human cloned isozyme (hCA IX) by CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2005) 48: 4834-4841 [PMID:16033263]
ChEMBL	Inhibitory constant against human Carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 2359-2364 [PMID:15837325]
ChEMBL	Inhibition constant against human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against catalytic domain of human cloned Carbonic anhydrase IX by the CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4872-4876 [PMID:16165351]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by stopped-flow CO2 hydrase assay	B	7.47	pKi	34	nM	Ki	J Med Chem (2006) 49: 5544-5551 [PMID:16942027]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of human cloned CA9 catalytic domain by CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2006) 49: 6539-6548 [PMID:17064072]
ChEMBL	Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of catalytic domain of human recombinant CA IX	B	7.47	pKi	34	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of catalytic domain of human recombinant isozyme CA9 by CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2007) 50: 1651-1657 [PMID:17343373]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2007) 15: 2298-2311 [PMID:17276072]
ChEMBL	Inhibition of human cloned catalytic domain CA9 by CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2007) 17: 5032-5035 [PMID:17681760]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA9 by CO2 hydration stopped flow assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human CA9 catalytic domain by CO2 hydration method	B	7.47	pKi	34	nM	Ki	J Med Chem (2008) 51: 1945-1953 [PMID:18307288]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 by CO2 hydration stopped-flow assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2008) 18: 3475-3480 [PMID:18513964]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay	B	7.47	pKi	34	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human carbonic anhydrase 9	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3623-3627 [PMID:20478708]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human cloned catalytic domain of CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins by CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human CA9 after 15 mins by stopped-flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of human carbonic anhydrase 9 by by stopped flow CO2 hydration method	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 3283-3290 [PMID:15149691]
ChEMBL	Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay	B	7.47	pKi	34	nM	Ki	Eur J Med Chem (2018) 143: 1931-1941 [PMID:29146134]
ChEMBL	Inhibition against human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 231-234 [PMID:14684333]
ChEMBL	Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	J Med Chem (2003) 46: 2187-2196 [PMID:12747790]
ChEMBL	Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2003) 13: 1005-1009 [PMID:12643899]
ChEMBL	Inhibitory activity against human carbonic anhydrase IX	B	7.47	pKi	34	nM	Ki	Bioorg Med Chem Lett (2004) 14: 2351-2356 [PMID:15081039]
ChEMBL	Inhibitory concentration against catalytic domain of human cloned carbonic anhydrase IX.	B	7.47	pKi	34	nM	Ki	J Med Chem (2003) 46: 2197-2204 [PMID:12747791]
ChEMBL	Inhibition of GST-tagged recombinant carbonic anhydrase-9 catalytic domain (unknown origin)	B	9	pIC50	0.99	nM	IC50	Bioorg Med Chem Lett (2013) 23: 3496-3499 [PMID:23664215]
ChEMBL	Inhibition of human carbonic anhydrase-9 incubated for 15 mins prior to testing by stopped-flow CO2 hydration assay	B	9.6	pIC50	0.25	nM	IC50	Medchemcomm (2018) 9: 2100-2105 [PMID:30746068]
carbonic anhydrase 5A/Carbonic anhydrase VA in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4789] [GtoPdb: 3093] [UniProtKB: P35218]
ChEMBL	Inhibitory activity against human recombinant mitochondrial isozyme CA VA	B	7.6	pKi	25	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of human cloned CA5A by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human carbonic anhydrase 5A	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA5A by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human carbonic anhydrase 5a preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
Carbonic anhydrase VB in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3969] [UniProtKB: Q9Y2D0]
ChEMBL	Inhibitory activity against human recombinant mitochondrial isozyme CA VB	B	7.72	pKi	19	nM	Ki	J Med Chem (2005) 48: 7860-7866 [PMID:16302824]
ChEMBL	Inhibition of human cloned CA5B by stopped-flow CO2 hydration method	B	7.72	pKi	19	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human carbonic anhydrase 5B	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped flow CO2 hydration assay	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA5B by stopped-flow CO2 hydration method	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human carbonic anhydrase 5b preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant CA5B mitochondrial isoform by stopped-flow CO2 hydration assay	B	7.72	pKi	19	nM	Ki	Bioorg Med Chem Lett (2011) 21: 1334-1337 [PMID:21300547]
Carbonic anhydrase VI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3025] [UniProtKB: P23280]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 6 expressed in Escherichia coli Rosetta2 (DE3) by thermal shift assay	B	7.48	pKd	33	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human carbonic anhydrase 6 esterase activity using 4-nitrophenylacetate as substrate	B	5.8	pKi	1580	nM	Ki	Bioorg Med Chem Lett (2012) 22: 1352-1357 [PMID:22230050]
ChEMBL	Inhibition of human carbonic anhydrase 6 using 4-nitrophenylacetate as substrate after 3 mins using spectrophotometry by Lineweaver-Burk plot analysis	B	5.8	pKi	1580	nM	Ki	Eur J Med Chem (2012) 49: 68-73 [PMID:22245047]
ChEMBL	Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped flow CO2 hydration assay	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA6 by stopped-flow CO2 hydration method	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human recombinant CA VI	B	7.37	pKi	43	nM	Ki	J Med Chem (2007) 50: 381-388 [PMID:17228881]
ChEMBL	Inhibition of human carbonic anhydrase 6 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem Lett (2011) 21: 710-714 [PMID:21208801]
ChEMBL	Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay	B	7.37	pKi	43	nM	Ki	J Med Chem (2009) 52: 646-654 [PMID:19193158]
ChEMBL	Inhibition of human carbonic anhydrase 6	B	7.37	pKi	43	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL	Binding affinity to human recombinant CA7 at 37 degC and pH 7.0 by thermal shift assay	B	9.15	pKd	0.71	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 7 by thermal shift assay	B	9.15	pKd	0.71	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	9.1	pKi	0.8	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human cloned CA7 by stopped-flow CO2 hydration method	B	9.1	pKi	0.8	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human carbonic anhydrase 7	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped flow CO2 hydration assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant full length CA7 by stopped-flow CO2 hydration method	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 7 by stopped flow CO2 hydration method	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 3170-3173 [PMID:19435663]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2013) 21: 5168-5174 [PMID:23867389]
ChEMBL	Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
GtoPdb	-	-	9.1	pKi	0.8	nM	Ki	Bioorg Med Chem (2013) 21: 5973-82 [PMID:23965175]
ChEMBL	Ki value against human carbonic anhydrase VII	B	9.11	pKi	0.78	nM	Ki	Bioorg Med Chem Lett (2005) 15: 971-976 [PMID:15686895]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL	Binding affinity to human recombinant CA12 at 37 degC and pH 7.0 by thermal shift assay	B	7.44	pKd	36	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 12 by thermal shift assay	B	7.44	pKd	36	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain preincubated for 15 mins by stopped-flow CO2 hydration assay	B	7.25	pKi	56	nM	Ki	J Med Chem (2012) 55: 6776-6783 [PMID:22775345]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22.1	nM	Ki	Bioorg Med Chem Lett (2014) 24: 1310-1314 [PMID:24507918]
ChEMBL	Inhibitory constant against catalytic domain of human carbonic anhydrase XII	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition constant against human carbonic anhydrase XII	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3096-3101 [PMID:15908204]
ChEMBL	Inhibitory activity against human Carbonic anhydrase XII (hCA XII)	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4862-4866 [PMID:16168653]
ChEMBL	Inhibition of human cloned CA12 catalytic domain by CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2006) 16: 4846-4851 [PMID:16809036]
ChEMBL	Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method	B	7.66	pKi	22	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human carbonic anhydrase 12	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human recombinant CA12 by CO2 hydration stopped flow assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2008) 18: 836-841 [PMID:18042384]
ChEMBL	Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration method	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human cloned catalytic domain of CA12 after 15 mins by stopped-flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2010) 45: 3656-3661 [PMID:20554082]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins by CO2 hydration method	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
ChEMBL	Inhibition of human cloned carbonic anhydrase 12 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2013) 21: 5973-5982 [PMID:23965175]
ChEMBL	Inhibition of human CA12 after 15 mins by stopped-flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2014) 71: 135-147 [PMID:24291567]
ChEMBL	Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2014) 22: 1586-1595 [PMID:24513184]
ChEMBL	Inhibition of human cloned transmembrane tumor-associated catalytic domain of carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2014) 82: 47-55 [PMID:24871996]
ChEMBL	Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2015) 25: 2377-2381 [PMID:25913118]
ChEMBL	Inhibition of human carbonic anhydrase 12 by by stopped flow CO2 hydration method	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem (2015) 23: 4989-4999 [PMID:26048024]
ChEMBL	Ki value against human carbonic anhydrase XII (hCA XII)	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-969 [PMID:15686894]
ChEMBL	Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay	B	7.66	pKi	22	nM	Ki	Eur J Med Chem (2018) 143: 1931-1941 [PMID:29146134]
ChEMBL	Inhibitory activity against catalytic domain of human carbonic anhydrase XII	B	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3821-3827 [PMID:16039853]
GtoPdb	-	-	7.66	pKi	22	nM	Ki	Bioorg Med Chem Lett (2005) 15: 963-9 [PMID:15686894]
carbonic anhydrase 13/Carbonic anhydrase XIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3912] [GtoPdb: 2748] [UniProtKB: Q8N1Q1]
ChEMBL	Binding affinity to human recombinant CA13 at 37 degC and pH 7.0 by thermal shift assay	B	7.89	pKd	13	nM	Kd	Bioorg Med Chem (2013) 21: 2093-2106 [PMID:23394791]
ChEMBL	Binding affinity to human recombinant carbonic anhydrase 13 by thermal shift assay	B	7.89	pKd	13	nM	Kd	Bioorg Med Chem (2013) 21: 6937-6947 [PMID:24103428]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL	Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped flow CO2 hydration assay	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of mouse recombinant full length CA13 by stopped-flow CO2 hydration method	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of full length mouse carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.3	pKi	50	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
GtoPdb	-	-	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-33 [PMID:16039848]
ChEMBL	Inhibition of human recombinant CA14 by CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2007) 17: 987-992 [PMID:17157501]
ChEMBL	Inhibition of human cloned full length carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2011) 46: 4403-4410 [PMID:21820216]
ChEMBL	Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3828-3833 [PMID:16039848]
ChEMBL	Inhibition of human carbonic anhydrase 14	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem (2007) 15: 4336-4350 [PMID:17475500]
ChEMBL	Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2008) 18: 2669-2674 [PMID:18359629]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2009) 19: 1371-1375 [PMID:19186056]
ChEMBL	Inhibition of human cloned CA14 by stopped-flow CO2 hydration method	B	7.6	pKi	25	nM	Ki	J Med Chem (2006) 49: 7024-7031 [PMID:17125255]
ChEMBL	Inhibition of full length human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay	B	7.6	pKi	25	nM	Ki	Bioorg Med Chem Lett (2010) 20: 3601-3605 [PMID:20472429]
ChEMBL	Inhibition of human full length carbonic anhydrase 14 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.6	pKi	25	nM	Ki	Eur J Med Chem (2010) 45: 2396-2404 [PMID:20202722]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by stopped flow CO2 hydration assay	B	8.6	pKi	2.5	nM	Ki	Eur J Med Chem (2014) 71: 105-111 [PMID:24287559]
ChEMBL	Inhibition of human recombinant full length CA14 by stopped-flow CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2009) 17: 1214-1221 [PMID:19119014]
ChEMBL	Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration method	B	8.6	pKi	2.5	nM	Ki	Bioorg Med Chem (2011) 19: 3105-3119 [PMID:21515057]
Delta carbonic anhydrase in Thalassiosira weissflogii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3097982] [UniProtKB: Q5U9J1]
ChEMBL	Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	B	7.07	pKi	85.1	nM	Ki	Bioorg Med Chem Lett (2014) 24: 275-279 [PMID:24314394]
Uncharacterized protein Rv1284/MT1322 in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5631] [UniProtKB: P9WPJ7]
ChEMBL	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay	B	5.99	pKi	1030	nM	Ki	J Med Chem (2009) 52: 3116-3120 [PMID:19338333]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]