repaglinide [Ligand Id: 6841] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1272 (A10BX02, AG-EE 623 ZW, AG-EE-623-ZW, AG-EE-623ZW, AGEE-623ZW, Enyglid, Novonorm, NSC-759893, Prandin, Repaglinide) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
| ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 5.04 | pIC50 | 9200 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 8/Sulfonylurea receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2071] [GtoPdb: 2594] [UniProtKB: Q09428] | ||||||||
| ChEMBL | Displacement of [3H]glibenclamide from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) | B | 7.3 | pKd | 50 | nM | Kd | Bioorg Med Chem Lett (2004) 14: 5205-5209 [PMID:15380228] |
| GtoPdb | - | - | 6.97 | pIC50 | 106 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5205-9 [PMID:15380228] |
| ChEMBL | In vitro displacement of [3H]glibenclamide (IC50=0.61) from COS-1 cells expressing Sulfonylurea receptor 1 (SUR-1) | B | 6.97 | pIC50 | 106 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 5205-5209 [PMID:15380228] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
