dextrothyroxine [Ligand Id: 6951] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL559 (Choloxin, Dextrothyroxine, D-thyroxine, Liotrix, Thyroxine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
| ChEMBL | Ability to displace [3H]L-689560 from NMDA receptor glycine site in rat brain membranes | B | 6.48 | pIC50 | 330 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1145-1150 |
| OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells | F | 6.57 | pKi | 270 | nM | Ki | Endocrinology (2004) 145: 4384-4391 [PMID:15166123] |
| Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3917] [GtoPdb: 589] [UniProtKB: P18113] | ||||||||
| ChEMBL | In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (1995) 38: 695-707 [PMID:7861417] |
| ChEMBL | In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1995) 38: 695-707 [PMID:7861417] |
| transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
| ChEMBL | Inhibition of transthyretin fibril formation at pH 4.4 | F | 5.14 | pIC50 | 7170 | nM | IC50 | J Med Chem (2007) 50: 5589-5599 [PMID:17948976] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
