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ChEMBL ligand: CHEMBL584335 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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coactivator associated arginine methyltransferase 1/Histone-arginine methyltransferase CARM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5406] [GtoPdb: 1255] [UniProtKB: Q86X55] | ||||||||
GtoPdb | - | - | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5063-6 [PMID:19632837] |
ChEMBL | Inhibition of human CARM1 assessed as inhibition of histone3 methylation | B | 10.15 | pIC50 | 0.07 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5063-5066 [PMID:19632837] |
protein arginine methyltransferase 1 /Protein-arginine N-methyltransferase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5524] [GtoPdb: 1252] [UniProtKB: Q99873] | ||||||||
ChEMBL | Inhibition of PRMT1 | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5063-5066 [PMID:19632837] |
protein arginine methyltransferase 3/Protein arginine N-methyltransferase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5891] [GtoPdb: 1254] [UniProtKB: O60678] | ||||||||
ChEMBL | Inhibition of PRMT3 | B | 4.6 | pIC50 | >25000 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 5063-5066 [PMID:19632837] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]