ChEMBL ligand: CHEMBL963 (14-hydroxydihydromorphinone, 7,8-dihydro-14-hydroxymorphinone, Dihydroxymorphinone, IDS-NO-003, NIH 10323, NSC-19045, Numorphan, Opana, Oxycodone hydrochloride impurity, oxymorphone-, Oxymorphone, Oxymorphone cii)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor/Kappa opioid receptor in Rat [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975] Kappa opioid receptor in Guinea pig [ChEMBL: CHEMBL3952] [UniProtKB: P41144] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Mouse [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] Mu opioid receptor in Guinea pig [ChEMBL: CHEMBL4354] [UniProtKB: P97266] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Binding affinity against Opioid receptor delta 1 of guinea pig brain membranes using 1 nM of [3H]DADLE as radioligand	B	6.84	pKi	145	nM	Ki	J Med Chem (1986) 29: 1222-1225 [PMID:2879914]
ChEMBL	Displacement of [3H]-diprenorphine from recombinant human DOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting	B	7.15	pKi	70	nM	Ki	J Med Chem (2017) 60: 9407-9412 [PMID:29053268]
ChEMBL	Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor delta 1 at a a temperature 25 degree Celsius labeled with [3H](D-Ala2-D-Leu5)-enkephalin (0.7 nM)	B	7.3	pKi	50	nM	Ki	J Med Chem (1985) 28: 974-976 [PMID:2409281]
ChEMBL	Inhibition of Opioid receptor delta 1 by displacing 1 nM [3H]DPDPE in guinea pig brain membrane	B	7.35	pIC50	45	nM	IC50	J Med Chem (1992) 35: 4589-4594 [PMID:1335078]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	Displacement of [3H]- diprenorphine from delta-receptor expressed in HEK 293 cells	B	6.14	pKi	730	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]-DPDPE from mouse DOR expressed in HEK293 cells	B	6.14	pKi	724.44	nM	Ki	ACS Med Chem Lett (2012) 3: 640-644 [PMID:23585918]
ChEMBL	Displacement of [3H]- diprenorphine from delta-W284E-receptor expressed in HEK 293 cells	B	6.21	pKi	610	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
ChEMBL	Inhibition of [3H][Ile5,6]deltorphin II binding to opioid receptor delta from rat brain membranes	B	7.09	pKi	80.5	nM	Ki	J Med Chem (2005) 48: 3372-3378 [PMID:15857143]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]-HS665 from recombinant human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting	B	7.6	pKi	25.3	nM	Ki	J Med Chem (2017) 60: 9407-9412 [PMID:29053268]
κ receptor/Kappa opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3614] [GtoPdb: 318] [UniProtKB: P34975]
ChEMBL	Displacement of [3H]diprenorphine from k-Y312A-receptor expressed in HEK 293 cells	B	6.36	pKi	435	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]diprenorphine from opioid receptor kappa 1 expressed in HEK 293 cells	B	6.68	pKi	208	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]diprenorphine from k-E297A-receptor expressed in HEK 293 cells	B	7.02	pKi	95	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL	Binding affinity against Opioid receptor kappa 1 of guinea pig brain membranes using 1 nM of (-)-[3H]ethylketazocine as radioligand	B	6.14	pKi	725	nM	Ki	J Med Chem (1986) 29: 1222-1225 [PMID:2879914]
ChEMBL	Inhibitory binding constant in guinea pig brain homogenate was reported at Opioid receptor kappa 1 at temperature 25 degree Celsius labeled with (-)-[3H]immazocine (0.1 nM).	B	6.86	pKi	137	nM	Ki	J Med Chem (1985) 28: 974-976 [PMID:2409281]
ChEMBL	Inhibition of [3H]U-69593 binding to opioid receptor kappa from guinea pig brain membranes	B	7.21	pKi	61.6	nM	Ki	J Med Chem (2005) 48: 3372-3378 [PMID:15857143]
ChEMBL	Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum homogenate by scintillation counting	B	7.24	pKi	57.6	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4104-4107 [PMID:21641798]
ChEMBL	Inhibition of opioid receptor kappa by displacing 0.5 nM [3H]bremazocine in guinea pig brain membrane	B	6.2	pIC50	630	nM	IC50	J Med Chem (1992) 35: 4589-4594 [PMID:1335078]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]-DAMGO from recombinant human MOR expressed in CHO cell membranes after 60 mins by liquid scintillation counting	B	8.75	pKi	1.79	nM	Ki	J Med Chem (2017) 60: 9407-9412 [PMID:29053268]
ChEMBL	Agonist activity at recombinant human MOR expressed in CHO cell membranes after 60 mins by [35S]GTPgammaS binding assay	F	8.11	pEC50	7.8	nM	EC50	J Med Chem (2017) 60: 9407-9412 [PMID:29053268]
μ receptor/Mu opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2858] [GtoPdb: 319] [UniProtKB: P42866]
ChEMBL	Displacement of [3H]-DAMGO from mouse MOR expressed in HEK293 cells	B	8.3	pKi	5.01	nM	Ki	ACS Med Chem Lett (2012) 3: 640-644 [PMID:23585918]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Displacement of [3H]- diprenorphine from mu-K303E-receptor expressed in HEK 293	B	7.58	pKi	26.2	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]- diprenorphine from mu-W318A-receptor expressed in HEK 293	B	7.64	pKi	23.1	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Displacement of [3H]- diprenorphine from mu-receptor expressed in HEK 293 cells	B	7.76	pKi	17.4	nM	Ki	J Med Chem (2001) 44: 857-862 [PMID:11300867]
ChEMBL	Inhibition of [3H]DAMGO binding to opioid receptor mu from rat brain membranes	B	9.01	pKi	0.97	nM	Ki	J Med Chem (2005) 48: 3372-3378 [PMID:15857143]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL	Binding affinity against Opioid receptor mu 1 of guinea pig brain membranes using 0.5 nM of [3H]naloxone as radioligand	B	7.82	pKi	15	nM	Ki	J Med Chem (1986) 29: 1222-1225 [PMID:2879914]
ChEMBL	Inhibitory binding constant in guinea pig brain homogenate was reported at mu site at a temperature 25 degree Centigrade labeled with [3H](D-Ala2-MePhe4,Gly-ol5)enkephalin(1 nM)	B	9.11	pKi	0.78	nM	Ki	J Med Chem (1985) 28: 974-976 [PMID:2409281]
ChEMBL	Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation counting	B	9.27	pKi	0.54	nM	Ki	Bioorg Med Chem Lett (2011) 21: 4104-4107 [PMID:21641798]
ChEMBL	Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain membrane	B	8.85	pIC50	1.4	nM	IC50	J Med Chem (1992) 35: 4589-4594 [PMID:1335078]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]