prednisone [Ligand Id: 7096] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL635 (3en3hg4wsw, Cortan, Cortancyl, Decortin, Decortisyl, Dehydrocortisone, Delta-dome, Deltasone, Fernisone, Liquid pred, Lodotra, Metacortandracin, Meticorten, NSC-10023, Orasone, Paracort, Prednicen-m, Prednisone, Prednisone anhydrous, Prednisone intensol, Prednisone tablets, Rayos, Servisone, Sterapred, Supercortil) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] | ||||||||
| ChEMBL | Induction of translocation of human glucocorticoid receptor expressed in HEK293T cells transduced with lentiviral vector expressing H2B-mCherry and GFP-GR assessed as effective dissociation constant measured every 130 sec for 22 mins by fluorescence imaging analysis | B | 7.54 | pKd | 29 | nM | Kd | RSC Med Chem (2021) 12: 203-212 [PMID:34046609] |
| GtoPdb | - | - | 6.28 | pKi | 521 | nM | Ki | National Toxicology Program: Dept of Health and Human Services.. DrugMatrix |
| ChEMBL | DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) | B | 6.28 | pKi | 521 | nM | Ki | DrugMatrix in vitro pharmacology data |
| ChEMBL | DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone) | B | 5.94 | pIC50 | 1146 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
